Endoscopic findings after CT proven acute diverticulitis: a systematic review and meta‐analysis

Abstract

Background Traditionally, international guidelines recommend patients with acute diverticulitis should be followed up with a colonoscopy 6–8 weeks after discharge. However, the need for an interval colonoscopy has been increasingly challenged in the setting of computed tomography (CT). Previous meta‐analyses have included studies which combined suspected rather than imaging confirmed diverticulitis and often without correlation with endoscopic findings. This meta‐analysis aims to investigate endoscopic findings of patients with CT confirmed diverticulitis. Methods An electronic search of Medline, PubMed, Cochrane Library, Embase, CINAHL, Web of Science, Scopus, Clinicaltrials.gov and WHO ICTRP was performed up to October 18, 2021. Studies which reported CT confirmed acute diverticulitis in adults and who underwent endoscopic follow‐up with either a colonoscopy or flexible sigmoidoscopy were included. Studies were excluded if diverticulitis was diagnosed by clinical grounds alone, ultrasound, barium enema, or other non‐CT forms of imaging. Results A total of 68 studies with 13 905 patients were included. Median age was 58 years and male to female ratio was 0.84. Cancer was detected in 2.0% and advanced adenoma in 3.8%. Complicated diverticulitis had 9.2 higher odds of cancer compared to uncomplicated diverticulitis (95% CI 4.42–19.08, P < 0.001). Adenomas were detected in 17%. Of those diagnosed with colorectal cancer, 85% were concordant with the site of the diverticulitis on CT while 15% were incidental findings. Conclusion Routine colonoscopic follow up should be recommended in medically fit patients who have CT proven acute diverticulitis due to the higher than population prevalence of colorectal cancer and advanced adenomas.

Diverticulitis Is Associated with Increased Risk of Colon Cancer—A Nationwide Register-Based Cohort Study

“…We found an increased risk of colon cancer in patients with complicated diverticulitis compared with uncomplicated diverticulitis in the adjusted analysis. Our results are aligned with the conclusions of two recent meta-analyses [42,46]. In our analysis, the difference in risk was only merely significant when adjusting for surgery.…”

“…We believe this to be due to a screening effect from the follow-up colonoscopy. Previous studies have found that 14-31% had adenomas upon colonoscopy after an episode of diverticulitis [41][42][43][44]. In a recently published systematic review, we also found that there was no increased long-term risk of colon cancer from six months after an episode of diverticulitis [45].…”

Evaluation of the frequency of colon diverticula with lower gastrointestinal system endoscopy

“…Of those diagnosed with colorectal cancer, 85% were concordant with the site of the diverticulitis on CT, while 15% were incidental findings. They recommended routine colonoscopic follow-up in convenient individuals [18]. Laurie et al conducted a retrospective analysis to compare colonoscopy versus post-computed tomography for confirmed diverticulitis.…”