Endoscopic endonasal management of esthesioneuroblastoma: A retrospective multicenter study

Nakagawa, Takayuki; Kodama, Satoru; Kobayashi, Masayoshi; Sanuki, Tetsuji; Tanaka, Shuho; Hanai, Nobuhiro; Hanazawa, Toyoyuki; Monobe, Hiroko; Yokoi, Hidenori; Suzuki, Motohiko; Yamashita, Masaru; Omori, Koichi

doi:10.1016/j.anl.2017.05.001

Cited by 31 publications

(14 citation statements)

References 19 publications

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“…Of these, 15 articles published IPD within the manuscript or as a supplement. 6,7,10,19-30 Of the articles that did not include IPD, 15 corresponding authors were contacted to provide raw data for their studies. 3,31-45 Six authors responded, and 5 provided IPD.…”

Section: Resultsmentioning

confidence: 99%

Comparing Kadish and Modified Dulguerov Staging Systems for Olfactory Neuroblastoma: An Individual Participant Data Meta‐analysis

Arnold

Farnoosh

Gore

2020

Otolaryngol.--head neck surg.

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Objective To compare the Kadish and the modified Dulguerov staging of individual participants to determine the impact of stage and other prognostic factors on disease-free (DFS) and overall survival (OS). Data Sources Systematic review of EMBASE, MEDLINE, Cochrane Library, and CINAHL databases. Review Methods The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) was followed for this study. Articles including patients with olfactory neuroblastoma (ONB) staged with both Kadish and Dulguerov staging systems were reviewed. The raw data from eligible studies were requested to perform an individual participant data (IPD) meta-analysis. Results Pooled data from 21 studies representing 399 patients with ONB undergoing treatment with curative intent showed that increasing age, treatment with chemotherapy, and positive or unreported margin status portended worse DFS ( P < .05). Increasing stage for both Kadish and Dulguerov staging systems was prognostic for worse DFS and OS ( P < .05), with Kadish C representing a heterogeneous group with regard to outcome and corresponding Dulguerov T stage. Using the Akaike information criterion, the Dulguerov staging system had superior performance to the Kadish system for DFS (1088.72 vs 1092.54) and OS (632.71 vs 644.23). Conclusion This study represents the first IPD meta-analysis of ONB directly comparing the outcomes of Kadish and Dulguerov staging systems in patients treated with primary surgery. Both systems correlated with DFS and OS, with superior performance in the Dulguerov system. Furthermore, the Kadish C group represented a heterogeneous group with regard to outcomes after stratification by the Dulguerov system. Dulguerov T4 patients had the worst outcome, with most being approached with open resection.

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Section: Resultsmentioning

confidence: 99%

Comparing Kadish and Modified Dulguerov Staging Systems for Olfactory Neuroblastoma: An Individual Participant Data Meta‐analysis

Arnold

Farnoosh

Gore

2020

Otolaryngol.--head neck surg.

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“…Folbe et al (44) also proved that endoscopic surgery can achieve a high rate of negative margin, even in the Kadish C stage. Nakagawa et al (45) reported that 95.5% (21/22) of patients had negative margin after endoscopic surgery. Unfortunately, in our study, the surgical margin of patients was not accurately obtained.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Survival Outcomes and Treatment Experience of 64 Patients With Esthesioneuroblastoma

Zeng

Tian

et al. 2021

Front. Oncol.

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Background: Esthesioneuroblastoma (ENB) is a rare sinonasal malignancy, lacking a unified staging system and treatment. Management at a single center was retrospectively evaluated to inform future treatment options and prognostic factors.Methods: Clinical data of 64 consecutive ENB patients, including prognostic factors and treatment methods, were reviewed retrospectively. Data were collected to calculate overall survival (OS) and progression free survival (PFS).Results: The majority of tumors 84.4% were within Kadish C stage, 79.7% were within T3 or T4, and 64.0% were within Hyams grade III or IV. A total of 50 (78.1%) patients received surgery and combined radiotherapy with or without chemotherapy, 10 (15.6%) received surgery with or without chemotherapy alone, and 4 (6.3%) received radiotherapy with or without chemotherapy alone. The majority of patients (79.7%) underwent endoscopic resection (endoscopic and endoscopically assisted). Surgery combined with radiotherapy with or without chemotherapy resulted in significantly better OS (84.4 vs. 50.6%, 84.4 vs. 37.5%) compared to surgery alone and radiotherapy alone (P = 0.0064). Endoscopic surgery group (endoscopic and endoscopically assisted) resulted in significantly better 5-year PFS (61.7 vs. 22.2%) compared to the open surgery group (P < 0.001). Although endoscopic surgery group was not a statistically significant predictor of 5-year OS (P = 0.54), the 5-year OS was 79.3% for the endoscopic surgery group and 76.2% for the open surgery group. A Cox regression analysis identified intracranial extension and surgery combined with radiotherapy as independent factors affecting 5-year OS while cervical lymph node metastasis and Hyams grade IV as independent factors affecting 5-year PFS.Conclusion: Our findings suggest that surgery combined with radiotherapy is the best treatment approach for ENB. For advanced tumors, endoscopic surgery is an effective treatment, and its survival rate is equal to or better than open surgery.

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“…Recently, EEA has been accepted as a common surgical method as an alternative to CFA. Previous reports have indicated that endoscopic resection can replace traditional craniofacial resection in select patients with ONBs ( 1 , 6 – 9 ). Rimmer et al reviewed 95 patients with ONB for a mean follow-up of 89 months, who were treated with endoscopic or craniofacial resection and reported no significant difference in outcomes between endoscopic and craniofacial resection ( 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, the treatment modalities have changed. Based on remarkable progress in technology, endoscopic endonasal approaches (EEAs) have gained acceptance and become an alternative standard for the surgical treatment of ONB (1,(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Olfactory Neuroblastoma: Surgical Treatment Experience of 42 Cases

et al. 2022

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ObjectiveOur purpose was to estimate the safety and effectiveness of the endoscopic endonasal approach (EEA) in olfactory neuroblastoma (ONB) and determine whether preservation of the dura and olfactory bulb could be considered in selected patients.MethodsWe retrospectively reviewed patients diagnosed with ONBs between July 2010 and June 2021 at our institution, and collected data on demographic, disease stage, surgical approach, overall survival (OS), disease-free survival (DFS), and postoperative complications.ResultsThe study sample included 42 patients (8 treated for recurrence and 34 initial cases), 28 of which were men and 14 were women with a median age of 47.19 years. The mean duration from the beginning of treatment and follow-up time was 8.91 and 51 months, respectively. Among the 42 patients, 32 had unilateral lesions, and the rest had bilateral lesions. Patient symptoms were predominantly nasal, and four patients presented without any symptoms. The modified Kadish staging was A in three patients, B in 14 patients, C in 17 patients, and D in 8 patients. According to the preoperative examinations, five patients had cervical lymph node metastasis, and no patients had distant metastases. EEA was used in 38 patients, cranioendoscopic approach in 3, and open craniofacial approach in 1. The 5-year OS and DFS rates were 89.1 and 79.2%, respectively. The 2-year OS and DFS rates were both 89.1%. The overall surgical complication incidence was 9.52% (one cerebrospinal fluid rhinorrhea, one cervical hematoma, and two epileptic seizures).ConclusionThe present results support the importance of earlier treatment for advanced ONB and the fact that it is safe and efficacious to treat ONBs via EEA. The preservation of the dura can be considered for select patients—specifically those without skull base involvement and who underwent postoperative comprehensive therapy.

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Endoscopic endonasal management of esthesioneuroblastoma: A retrospective multicenter study

Cited by 31 publications

References 19 publications

Comparing Kadish and Modified Dulguerov Staging Systems for Olfactory Neuroblastoma: An Individual Participant Data Meta‐analysis

Comparing Kadish and Modified Dulguerov Staging Systems for Olfactory Neuroblastoma: An Individual Participant Data Meta‐analysis

Long-Term Survival Outcomes and Treatment Experience of 64 Patients With Esthesioneuroblastoma

Olfactory Neuroblastoma: Surgical Treatment Experience of 42 Cases

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