Endoscopic diagnosis of early <scp>B</scp>arrett's neoplasia: <scp>P</scp>erspectives for advanced endoscopic technology

Goda, Kenichi; Kato, Tomohiro; Tajiri, Hisao

doi:10.1111/den.12294

Cited by 11 publications

(4 citation statements)

References 93 publications

(220 reference statements)

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“…Thus, the risk of progression to adenocarcinoma might be higher in cases with sharp localized SSBE than in those with round localized SSBE. Recently, the presence of histological intestinal metaplasia has been evaluated based on the mucosal patterns of BE, which can be determined via both magnified and non-magnified endoscopic observations ( 38 - 42 ). The difference in the histology and/or mucosal patterns of different types of SSBE should be investigated to clarify the associated risk of progression to adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Circumferential Locations of Different Shapes of Short-segment Barrett's Esophagus

et al. 2017

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Objective To clarify the relationship between the shape and circumferential location of non-circumferential short-segment Barrett's esophagus (SSBE). Methods We examined 3,788 subjects (2,497 males, 1,291 females; mean age 52.4 years) who underwent upper GI endoscopy as part of a detailed medical checkup. The presence of columnar-appearing mucosa ≥10 mm long in the distal esophagus was diagnosed as BE and then divided into circumferential and non-circumferential localized types. Localized SSBE was further divided into round and sharp types based on the shape of the proximal margin. Results SSBE was endoscopically observed in 197 subjects (5.2%). The numbers of patients with circumferential SSBE, round localized SSBE, and sharp localized SSBE were 38, 114 and 69, respectively. Round and sharp types of localized SSBE were simultaneously observed in 25 patients. Reflux esophagitis was more frequently observed in subjects with BE, regardless of type, in comparison to those without BE. Round localized SSBE was found mainly in the left posterior wall of the esophagus in a location similar to the main area of the esophageal cardiac glands. In contrast, sharp localized SSBE was observed mainly in the right anterior wall of the esophagus in a location similar to that of esophageal mucosal injury caused by mild type reflux esophagitis. Conclusion The location differs between round and sharp localized SSBE, possibly due to differences in the process of BE development.

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Section: Discussionmentioning

confidence: 99%

Circumferential Locations of Different Shapes of Short-segment Barrett's Esophagus

et al. 2017

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“… 17 Although the favorable report regarding ME-NBI based classification systems for BE has been published, none of these classifications has been in widespread use mainly because of their complexity. 18 , 45 In the present study, we developed the most simplified classification focusing only on CP not mucosal pattern. The strength of our classification is discussed in greater detail below.…”

Section: Discussionmentioning

confidence: 99%

Simplified Classification of Capillary Pattern in Barrett Esophagus Using Magnifying Endoscopy With Narrow Band Imaging

et al. 2015

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The classification of Barrett esophagus (BE) using magnifying endoscopy with narrow band imaging (ME-NBI) is not widely used in clinical settings because of its complexity. To establish a new simplified available classification using ME-NBI.We conducted a cross-sectional study in a single-referral center. One hundred eight consecutive patients with BE using ME-NBI and crystal violet (CV) chromoendoscopy, and histological findings were enrolled. BE areas observed by ME-NBI were classified as type I or II on the basis of capillary pattern (CP), and as closed or open type on the basis of a mucosal pit pattern using CV chromoendoscopy; then, biopsy samples were obtained. We evaluated the relation between CP and pit pattern, expression of the factors with malignant potential, percentage of microvascular density, and interobserver agreement.One hundred thirty lesions from 91 patients were analyzed. Type II CP had more open type pit pattern areas and significantly greater microvascular density than type I. The presence of dysplasia, specialized intestinal metaplasia, expressions of COX-2, CDX2, and CD34, and PCNA index were significantly higher in type II, whereas the multivariate analysis showed that type II was the best predictor for the presence of dysplasia (OR 11.14), CD34 expression (OR 3.60), and PCNA (OR 3.29). Interobserver agreement for this classification was substantial (κ = 0.66).A simplified CP classification based on observation with ME-NBI is presented. Our results indicate that the classification may be useful for surveillance of BE with high malignant potential.

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“…To overcome these problems, several advanced imaging techniques, including chromoendoscopy, magnifying endoscopy, microscopic endoscopy, and tomographic endoscopy, have been developed. Table 2 shows the classification of these endoscopic imaging techniques and their sensitivity and specificity for the detection of dysplasia or EAC arising from BE (35)(36)(37)(38). Regarding conventional endoscopy, high-resolution (HD) endoscopy was developed and has improved image quality; however, its dysplasia detection rate alone is reported to be 79% (39).…”

Section: Diagnostic Methodsmentioning

confidence: 99%

Endoscopy and Barrett's Esophagus: Current Perspectives in the US and Japan

et al. 2021

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Barrett's esophagus (BE) is a precancerous disease that can lead to esophageal adenocarcinoma (EAC). Recently, the incidence of EAC arising from BE has been increasing, and EAC has now become a threat in many countries. However, there are many gaps among the various countries in terms of definitions and concepts and these gaps prevent discussing BE on the same footing. In order to eradicate BE, it is a global necessity to fill in these remaining gaps. We focused on the gaps and reviewed recent evidence and trends as well as the background of gaps between the US and Japan as two of the leading countries in the field of medical research. We also review the rapid advances in endoscopic techniques in relation to both diagnosis and therapy that are considered to be useful to eliminate the gaps between countries.

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Endoscopic diagnosis of early Barrett's neoplasia: Perspectives for advanced endoscopic technology

Cited by 11 publications

References 93 publications

Circumferential Locations of Different Shapes of Short-segment Barrett's Esophagus

Circumferential Locations of Different Shapes of Short-segment Barrett's Esophagus

Simplified Classification of Capillary Pattern in Barrett Esophagus Using Magnifying Endoscopy With Narrow Band Imaging

Endoscopy and Barrett's Esophagus: Current Perspectives in the US and Japan

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