Endometrial compaction does not predict the reproductive outcome after vitrified–warmed embryo transfer: a prospective cohort study

Olgan, Şafak; Dırıcan, Enver Kerem; Sakıncı, Mehmet; Caglar, Mete; Ozsıpahı, Arif Can; Gul, Saniye Merve; Humaıdan, Peter

doi:10.1016/j.rbmo.2022.02.025

Cited by 14 publications

(16 citation statements)

References 115 publications

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“…In contrast with Jin et al, Kaye showed that the CPR was higher in EC group [14]. In accordance with our study, Olgan determined that CPR did not differ between EC and noncompaction groups [15]. In the past, a fair number of studies concentrated upon the endometrial lining thickness rather than EC [16,17].…”

Section: Discussionsupporting

confidence: 87%

Investigating the impact of endometrial compaction on clinical pregnancy rate in artificial frozen-thawed embryo transfer cycles

Erdoğan

Sanlier

Özen

et al. 2023

Marmara Medical Journal

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Objective: The aim of our study was to evaluate sonographic endometrial thickness succeeding the estrogen-only stage and on the day when embryo transfer (ET) occurred in artificial frozen embryo transfer (FET) cycles to delve into the effect of endometrial compaction (EC) on clinical pregnancy rate (CPR). Patients and Methods: In the first group endometrial thickness diminished when ET occurred when compared to the end of the estrogen-only phase (n:37). Endometrial thickness increased/did not alter for the second group (n:70). Demographic characteristics were recorded and the following were studied: in vitro fertilization (IVF) treatment indications, hormone levels, total antral follicle count, duration of infertility, embryo quality, embryo-fundus distance, endometrial thickness at the end of estrogen-only phase and on ET day, luteal support, CPR. Results: No significant difference occurred in CPRs (n:107). ET, on day 5 was higher in the first group (p

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Section: Discussionsupporting

confidence: 87%

Investigating the impact of endometrial compaction on clinical pregnancy rate in artificial frozen-thawed embryo transfer cycles

Erdoğan

Sanlier

Özen

et al. 2023

Marmara Medical Journal

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“…The effect of endometrial thickness on the reproductive outcome is apparent (19). The interaction between the receptive endometrium and the embryo is a complicated molecular process that results in effective implantation (20). When the level of P4 reaches a critical threshold, it drives an orderly and timely secretory transformation of the endometrium, leading to receptivity (21).…”

Section: Discussionmentioning

confidence: 99%

The pregnancy results were not affected from the administration day of Depot GnRH agonists in artificial cycle frozen-thawed embryo transfers

AĞAR¹,

MADENLİ>

Güngör

et al. 2023

Journal of Medicine and Palliative Care

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Aim: In frozen-thawed embryo transfers (FET), Gonadotropin-Releasing Hormone (GnRH) agonists have recently been used to improve implantation results. It is preferred to administer it in the luteal phase of the previous cycle. The objective was to compare the effects of different administration days of depot GnRH agonists on implantation and pregnancy rates in the artificial cycle of FET. Material and Method: A retrospective case-control study was conducted in an in vitro fertilization (IVF) center in a university hospital, including all women starting an artificial cycle of FET. One thousand two hundred and twenty-seven (n:1227) FET cycles were scanned from the files from October 2014 to December 2021. Depot agonists (Lucrin depot 3.75 mg sc Abbott USA.-leuprolide acetate) were used in 219 patients with endometriosis. In 58 patients, it was administered on day 21 of the previous cycle (Group 1), and in 161 patients, it was administered on day 2 of the same cycle (Group 2). Results: This study showed no statistically significant difference between the two groups in laboratory parameters and endometrial thickness (p>0.05). There was no statistically significant association between the abort rate and transfer day (p>0.05). There was no statistically significant association between the pregnancy results and transfer day (p>0.05). The ongoing pregnancy rate (OPR) rate was relatively high in the second group compared to the twenty-first day of the previous cycle (87/161(54%) vs. 30/58 (51.7%)). The biochemical pregnancy was relatively high in the second-day group compared to the twenty-first day of the previous cycle (62/161(38.5%) vs. 21/58 (36.2%)). The abort rate was relatively high in the twenty-first-day group compared to the second day of the cycle (25/87(28.75%) vs. 9/30(30%)). Conclusion: In conclusion, the impacts of various administration days of depot Gonadotropin-releasing hormone (GnRH) agonists on implantation and pregnancy rates were not statistically significant.

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“…This was supported by Youngster, M., et al [ 141 ] in a retrospective observational study. However, several recent studies, including HRT cycles alone [ 142 , 143 ] or in combination with modified natural cycle (mNC) [ 144 – 146 ], failed to link endometrial compaction of ≥ 5% with pregnancy rates or live birth rates (LBRs). To avoid errors introduced by ultrasound measurement, EMT in these studies [ 142 , 143 ] was assessed via both transvaginal ultrasonography (TVUS) and AUS in all patients on the day of embryo transfer.…”

Section: Methodsmentioning

confidence: 99%

“…However, several recent studies, including HRT cycles alone [ 142 , 143 ] or in combination with modified natural cycle (mNC) [ 144 – 146 ], failed to link endometrial compaction of ≥ 5% with pregnancy rates or live birth rates (LBRs). To avoid errors introduced by ultrasound measurement, EMT in these studies [ 142 , 143 ] was assessed via both transvaginal ultrasonography (TVUS) and AUS in all patients on the day of embryo transfer. Furthermore, estrogen and progesterone concentrations were accessed to investigate hormonal reasons behind this event, and no connection with endometrial compaction was discovered.…”

Section: Methodsmentioning

confidence: 99%

Preparation of the endometrium for frozen embryo transfer: an update on clinical practices

Zhang¹,

Xiao²,

Gao³

et al. 2023

Reprod Biol Endocrinol

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Over the past decade, the application of frozen-thawed embryo transfer treatment cycles has increased substantially. Hormone replacement therapy and the natural cycle are two popular methods for preparing the endometrium. Hormone replacement therapy is now used at the discretion of the doctors because it is easy to coordinate the timing of embryo thawing and transfer with the schedules of the in-vitro fertilization lab, the treating doctors, and the patient. However, current results suggest that establishing a pregnancy in the absence of a corpus luteum as a result of anovulation may pose significant maternal and fetal risks. Therefore, a ‘back to nature’ approach that advocates an expanded use of natural cycle FET in ovulatory women has been suggested. Currently, there is increasing interest in how the method of endometrial preparation may influence frozen embryo transfer outcomes specifically, especially when it comes to details such as different types of ovulation monitoring and different luteal support in natural cycles, and the ideal exogenous hormone administration route as well as the endocrine monitoring in hormone replacement cycles. In addition to improving implantation rates and ensuring the safety of the fetus, addressing these points will allow for individualized endometrial preparation, also as few cycles as possible would be canceled.

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Endometrial compaction does not predict the reproductive outcome after vitrified–warmed embryo transfer: a prospective cohort study

Cited by 14 publications

References 115 publications

Investigating the impact of endometrial compaction on clinical pregnancy rate in artificial frozen-thawed embryo transfer cycles

Investigating the impact of endometrial compaction on clinical pregnancy rate in artificial frozen-thawed embryo transfer cycles

The pregnancy results were not affected from the administration day of Depot GnRH agonists in artificial cycle frozen-thawed embryo transfers

Preparation of the endometrium for frozen embryo transfer: an update on clinical practices

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