Endolymphatic Duct Pressure Produces Cochlear Damage

Perilymph fistula pathophysiology

“…The theory of inner ear membrane breaks in sudden hearing loss proposed by Simmons 3 was the next major conceptual advance in PLF. In this landmark paper he reviewed animal work by Lawrence and McCabe, 4 in which intense sound caused disruption of Reissner's membrane, and his own demonstration in cats of intracranially applied endolymphatic duct pressure causing sudden loss in electrical activity of the ear without signs of dysequilibrium 5 . Fee 6 gave the first report of PLF resulting from head trauma in patients with otherwise normal ears.…”

Sequential Electrocochleography and Auditory Dehydration Testing in Patients with Ménière's Disease

“…Animal studies have shown that the endocochlear potentials vary with respect to changes in intralabyrinthine fluid pressure and volume. [12][13][14] The clinical symptomatology, progressive hearing loss and vertigo, may be secondary to the fluctuating inner ear pressure causing cochlear basilar membrane distortion and cochlear vascular in- sufficiency with loss of sensory hair cells. The fluctuation of cochlear potentials, as measured by ECochG, (especially an enlarged SP) is well known to occur with increased symptomatology in patients with documented endolymphatic hydrops.…”

Urgent revision stapedectomy for sudden hearing loss

“…Various authors 13 , 14,15,16,17,18,19,20,21 have proposed changes in the pressure, and flow relationships in the endolymphatic duct as the prime concern in labyrinthine hypoactivity and decreased cochlear potentials. The current vogue of decompressive saccu10tomy22,23 for endolymphatic hydrops underscores otologists' concern over intracochlear and vestibular pressures.…”