Abstract:Abstract. The cell-surface receptor for advanced glycation end-products (RAGE) has been implicated in the development of diabetic vascular complications and Alzheimer's disease. RAGE has been considered to be involved in amyloid-␤ 1-42 (A␤ 1-42 ) uptake into brain. In the present study, we demonstrate that endogenous secretory RAGE (esRAGE), a decoy form of RAGE generated by alternative RNA processing, is able to inhibit A␤ 1-42 influx into mouse brain. Surface plasmon resonance and competitive binding assays … Show more
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