volume 28, issue 3, P709-720 2012
DOI: 10.3233/jad-2011-110776
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Abstract: Abstract. The cell-surface receptor for advanced glycation end-products (RAGE) has been implicated in the development of diabetic vascular complications and Alzheimer's disease. RAGE has been considered to be involved in amyloid-␤ 1-42 (A␤ 1-42 ) uptake into brain. In the present study, we demonstrate that endogenous secretory RAGE (esRAGE), a decoy form of RAGE generated by alternative RNA processing, is able to inhibit A␤ 1-42 influx into mouse brain. Surface plasmon resonance and competitive binding assays…

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