Abstract:Mutations in the gene for PTEN‐induced kinase 1 (PINK1) are linked to recessive Parkinson’s disease (PD) and PD with dementia (PDD). We previously discovered that overexpression of PINK1 promotes dendritic complexity through interaction with valosin containing protein (VCP) and activation of protein kinase A (PKA). Furthermore, treatment with a small molecule inhibitor of endogenous PINK1 degradation confers protection against the severe dendritic retraction elicited by 1‐methyl‐4‐phenylpyridinium (MPP+), a ne… Show more
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