Endocrine‐disrupting chemicals, risk of type 2 diabetes, and diabetes‐related metabolic traits: A systematic review and meta‐analysis

Song, Yan; Chou, Elizabeth L.; Baecker, Aileen; You, Nai Chieh Y.; Song, Yiqing; Sun, Qi; Liu, Simin

doi:10.1111/1753-0407.12325

Cited by 175 publications

(109 citation statements)

References 74 publications

(195 reference statements)

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“…Growing evidence suggests that presence of persistent organic pollutants (e.g., dioxins, polychlorinated biphenyls) may partly reduce cardiometabolic benefits of fish consumption; 213-215 less evidence suggests potential for net harm, due to the opposing benefits of omega-3's. Methylmercury consumed from fish has no detectable influence on incident cardiovascular events, hypertension, or diabetes.…”

Section: Foods and Cardiometabolic Healthmentioning

confidence: 99%

Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity

2016

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Suboptimal nutrition is a leading cause of poor health. Nutrition and policy science have advanced rapidly, creating confusion yet also providing powerful opportunities to reduce the adverse health and economic impacts of poor diets. This review considers the history, new evidence, controversies, and corresponding lessons for modern dietary and policy priorities for cardiovascular diseases, obesity, and diabetes. Major identified themes include the importance of evaluating the full diversity of diet-related risk pathways, not just obesity and blood lipids; focusing on foods and overall diet patterns, rather than single isolated nutrients; recognizing the complex influences of different foods on long-term weight regulation, rather than simply counting calories; and characterizing and implementing evidence-based strategies, including policy approaches, for lifestyle change. Evidence-informed dietary priorities include increased fruits, nonstarchy vegetables, nuts, legumes, fish, vegetable oils, yogurt, and minimally processed whole grains; and fewer red meats, processed (e.g., sodium-preserved) meats, and foods rich in refined grains, starch, added sugars, salt, and trans fat. More investigation is needed on cardiometabolic effects of phenolics, dairy fat, probiotics, fermentation, coffee, tea, cocoa, eggs, specific vegetable and tropical oils, vitamin D, individual fatty acids, and diet-microbiome interactions. Little evidence to-date supports cardiometabolic relevance of other popular priorities: e.g., local, organic, grass-fed, farmed/wild, non-GMO. Evidence-based personalized nutrition appears to depend more on non-genetic characteristics (e.g., physical activity, abdominal adiposity, gender, socioeconomic status, culture) than genetic factors. Food choices must be strongly supported by clinical behavior change efforts, health systems reforms, novel technologies, and robust policy strategies, including those targeting economic incentives, schools and workplaces, neighborhood environments, and the food system. Scientific advances provide crucial new insights on optimal targets and best practices to reduce burdens of diet-related cardiometabolic diseases.

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Section: Foods and Cardiometabolic Healthmentioning

confidence: 99%

Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity

2016

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“…These receptors play a critical role in normal biology and development [75], including energy balance and glucose homeostasis [76]. Though the exact mechanisms of action remain unknown, multiple studies support an association between endocrine disruptors and metabolic syndrome [77, 78], which may partially explain how chronic exposure to iAs has been associated with pathophysiological illnesses such as T2D.…”

Section: Arsenic and T2d Pathophysiologymentioning

confidence: 99%

Arsenic Exposure and Type 2 Diabetes: MicroRNAs as Mechanistic Links?

2017

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Purpose of ReviewThe goal of this review is to delineate the following: (1) the primary means of inorganic arsenic (iAs) exposure for human populations, (2) the adverse public health outcomes associated with chronic iAs exposure, (3) the pathophysiological connection between arsenic and type 2 diabetes (T2D), and (4) the incipient evidence for microRNAs as candidate mechanistic links between iAs exposure and T2D.Recent FindingsExposure to iAs in animal models has been associated with the dysfunction of several different cell types and tissues, including liver and pancreatic islets. Many microRNAs that have been identified as responsive to iAs exposure under in vitro and/or in vivo conditions have also been shown in independent studies to regulate processes that underlie T2D etiology, such as glucose-stimulated insulin secretion from pancreatic beta cells.SummaryDefects in insulin secretion could be, in part, associated with aberrant microRNA expression and activity. Additional in vivo studies need to be performed with standardized concentrations and durations of arsenic exposure in order to evaluate rigorously microRNAs as molecular drivers of iAs-associated diabetes.

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“…In this last decade, a number of studies have investigated the association between BPA and T2DM, mostly on the basis of the results derived from data of the National Health and Nutrition Examination Survey (NHANES) [5,6,7,8,9,10,11,32,33]. Lang et al found a positive association between urinary BPA levels and prevalence of T2DM using cross-sectional data from NHANES 2003–2004 [6].…”

Section: Epidemiological Evidences: Observational Studies In Humansmentioning

confidence: 99%

“…Indeed, either genetic or environmental factors contribute to the risk of occurrence of T2DM [4]. In particular, among the environmental factors, mounting evidence suggests that the exposure to environmental endocrine disrupting chemicals (EDCs) might play a role in the pathogenesis of T2DM [5]. …”

Section: Introductionmentioning

confidence: 99%

Influence of Bisphenol A on Type 2 Diabetes Mellitus

Provvisiero¹,

Pivonello

Muscogiuri³

et al. 2016

IJERPH

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Bisphenol A (BPA) is an organic synthetic compound employed to produce plastics and epoxy resins. It is used as a structural component in polycarbonate beverage bottles and as coating for metal surface in food containers and packaging. The adverse effects of BPA on human health are widely disputed. BPA has been recently associated with a wide variety of medical disorders and, in particular, it was identified as potential endocrine-disrupting compound with diabetogenic action. Most of the clinical observational studies in humans reveal a positive link between BPA exposure, evaluated by the measurement of urinary BPA levels, and the risk of developing type 2 diabetes mellitus. Clinical studies on humans and preclinical studies on in vivo, ex vivo, and in vitro models indicate that BPA, mostly at low doses, may have a role in increasing type 2 diabetes mellitus developmental risk, directly acting on pancreatic cells, in which BPA induces the impairment of insulin and glucagon secretion, triggers inhibition of cell growth and apoptosis, and acts on muscle, hepatic, and adipose cell function, triggering an insulin-resistant state. The current review summarizes the available evidences regarding the association between BPA and type 2 diabetes mellitus, focusing on both clinical and preclinical studies.

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Endocrine‐disrupting chemicals, risk of type 2 diabetes, and diabetes‐related metabolic traits: A systematic review and meta‐analysis

Abstract: Persistent and non-persistent EDCs may affect the risk of T2D. There is an urgent need for further investigation of EDCs, especially non-persistent ones, and T2D risk in large prospective studies.

Cited by 175 publications

References 74 publications

Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity

Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity

Arsenic Exposure and Type 2 Diabetes: MicroRNAs as Mechanistic Links?

Influence of Bisphenol A on Type 2 Diabetes Mellitus

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