Endocrine-disrupting chemicals: implications for human health

Kahn, Linda G.; Philippat, Claire; Nakayama, Shoji F.; Slama, Rémy; Trasande, Leonardo

doi:10.1016/s2213-8587(20)30129-7

Cited by 448 publications

(292 citation statements)

References 210 publications

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“…Ovarian cancer is one of the most common gynaecological malignancies, and is one of the major causes of gynaecological cancer-related mortality worldwide. 1 , 2 It is estimated that there were about 250,000 new cases and 160,000 deaths in 2018. 3 Various risk factors including a family history of ovarian cancer or breast cancer, overweight, smoking, earlier menstruation or later menopause and not giving birth have been suggested to contribute to the development of ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Identification of the Hub Genes Associated with the Prognosis of Ovarian Cancer Patients via Integrated Bioinformatics Analysis and Experimental Validation

Zhao

Liu

et al. 2021

CMAR

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Background This study aimed to identify the hub genes associated with prognosis of patients with ovarian cancer by using integrated bioinformatics analysis and experimental validation. Methods Four microarray datasets (GSE12470, GSE14407, GSE18521 and GSE46169) were analyzed by the GEO2R tool to screen common differentially expressed genes (DEGs). Gene Ontology, the Kyoto Encyclopedia of Genes and Genomes, the (KEGG) pathway and Reactome pathway enrichment analysis, protein–protein interaction (PPI) construction, and the identification of hub genes were performed. Furthermore, we performed the survival and expression analysis of the hub genes. In vitro functional assays were performed to assess the effects of hub genes on ovarian cancer cell proliferation, caspase-3/7 activity and invasion. Results A total of 89 common DEGs were identified among these four datasets. The KEGG and Reactome pathway results showed that the DEGs were mainly associated with cell cycle, mitotic and p53 signaling pathway. A total of 20 hub genes were identified from the PPI network by using sub-module analysis. The survival analysis revealed that high expression of six hub genes ( AURKA, BUB1B, CENPF, KIF11, KIF23 and TOP2A ) were significantly correlated with shorter overall survival and progression-free survival of patients with ovarian cancer. Furthermore, the expression of the six hub genes were validated by the GEPIA database and Human Protein Atlas, and functional studies revealed that knockdown of KIF11 and KIF23 suppressed the SKOV3 cell proliferation, increased caspase-3/7 activity and attenuated invasive potentials of SKOV3 cells. In addition, knockdown of KIF11 and KIF23 up-regulated E-cadherin mRNA expression but down-regulated N-cadherin and vimentin mRNA expression in SKOV3 cells. Conclusion Our results showed that six hub genes were up-regulated in ovarian cancer tissues and may predict poor prognosis of patients with ovarian cancer. KIF11 and KIF23 may play oncogenic roles in ovarian cancer cell progression via promoting ovarian cancer cell proliferation and invasion.

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Section: Introductionmentioning

confidence: 99%

Identification of the Hub Genes Associated with the Prognosis of Ovarian Cancer Patients via Integrated Bioinformatics Analysis and Experimental Validation

Zhao

Liu

et al. 2021

CMAR

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“…Knowing the pesticide contamination of playgrounds is important as they are often visited by children or pregnant women, who are considered particularly vulnerable [17]. Our previous finding, that most of the pesticides detected at playgrounds in South Tyrol are endocrine active (EDA) or endocrine-disrupting chemicals (EDC) [12] is worrisome because EDAs and EDCs affect the hormone balance of fetuses, children, and teenagers [18][19][20][21]. Moreover, residents living near agricultural areas with intensive pesticide use have been shown to develop several health deficiencies, including asthma, confusion, anxiety, weakness, problems with speaking and orientation, poor memory, frequent urination, and increased salivation [22].…”

Section: Introductionmentioning

confidence: 99%

Year-round pesticide contamination of public sites near intensively managed agricultural areas in South Tyrol

Linhart¹,

Panzacchi

Belpoggi

et al. 2021

Environ Sci Eur

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Background In a previous study, we found that 45% of public playgrounds near intensively managed agricultural areas were contaminated with mainly endocrine active pesticide residues in spring. Here, we investigated potential contamination over the course of a year. Methods Residue data were analyzed from 96 grass samples collected in spring, summer, autumn, and winter by the South Tyrolean Medical Service in 19 public playgrounds, four schoolyards, and one marketplace located within intensively managed agricultural landscapes. Samples were analyzed for 281 substances using gas-chromatography and mass-spectrometry. Results A total of 32 pesticide residues and one preservative agent were found. Almost all of the sites (96%) were contaminated with at least one residue during the year; in 79% of the sites, more than one residue was found. Among the detected residues, 76% are classified as endocrine active substances, with the highest concentrations of the insecticide chlorpyrifos-methyl (0.71 mg kg−1), the herbicide oxadiazon (0.64 mg kg−1), and the fungicides captan (0.46 mg kg−1) and fluazinam (0.23 mg kg−1). The number of residues, their concentrations, and the proportion of contaminated sites varied across seasons (p < 0.001). Twenty-five residues were found in 83% of the sites in spring (median concentration 0.240 mg kg−1), nine in 79% of the sites in summer (0.092 mg kg−1), three in 50% of the sites in autumn (0.076 mg kg−1), and four in 17% of the sites in winter (0.155 mg kg−1). Playgrounds already examined in 2017 in the previous study, were more often contaminated with multiple pesticide residues in 2018 (p = 0.045). Conclusion This study confirms previous findings of widespread pesticide contamination of public sites within intensively managed agricultural areas. Moreover, pesticide residues were also found in periods with little or no pesticide application in the field (autumn and winter). It is worrisome that many of the detected residues are endocrine active substances and that some of them (thiacloprid, bupirimate, captan, folpet) are “suspected human carcinogens”, according to EU authorities. Thus, we call for more effective controls of pesticide applications to minimize pesticide drift into public places.

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“…Still, there are many examples of chemicals in plastic packaging that are known or suspected endocrine disrupting chemicals [26,[48][49][50][51][52][53], such as benzophenone (CAS 119-61-9), 2,4-di-tert-butylphenol (CAS 96-76-4), or the styrene dimer 1,3-diphenylpropane (CAS 1081-75-0). Endocrine disruption is currently not routinely being addressed when chemicals are authorized for use in (plastic) food packaging [14,54].…”

Section: When Less Is More: Non-monotonic Dose Responses and Endocrinmentioning

confidence: 99%

Tackling the toxics in plastics packaging

Muncke

2021

PLoS Biol

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The widespread use of plastic packaging for storing, transporting, and conveniently preparing or serving foodstuffs is significantly contributing to the global plastic pollution crisis. This has led to many efforts directed toward amending plastic packaging’s end of life, such as recycling, or alternative material approaches, like increasingly using paper for food packaging. But these approaches often neglect the critical issue of chemical migration: When contacting foodstuffs, chemicals that are present in packaging transfer into food and thus unwittingly become part of the human diet. Hazardous chemicals, such as endocrine disrupters, carcinogens, or substances that bioaccumulate, are collectively referred to as “chemicals of concern.” They can transfer from plastic packaging into food, together with other unknown or toxicologically uncharacterized chemicals. This chemical transfer is scientifically undisputed and makes plastic packaging a known, and avoidable, source of human exposure to synthetic, hazardous, and untested chemicals. Here, I discuss this issue and highlight aspects in need of improvement, namely the way that chemicals present in food packaging are assessed for toxicity. Further, I provide an outlook on how chemical contamination from food packaging could be addressed in the future. Robust innovations must attempt systemic change and tackle the issue of plastic pollution and chemical migration in a way that integrates all existing knowledge.

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Endocrine-disrupting chemicals: implications for human health

Cited by 448 publications

References 210 publications

Identification of the Hub Genes Associated with the Prognosis of Ovarian Cancer Patients via Integrated Bioinformatics Analysis and Experimental Validation

Identification of the Hub Genes Associated with the Prognosis of Ovarian Cancer Patients via Integrated Bioinformatics Analysis and Experimental Validation

Year-round pesticide contamination of public sites near intensively managed agricultural areas in South Tyrol

Tackling the toxics in plastics packaging

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