Endocannabinoid and perceived stress: Association analysis of endocannabinoid levels in hair versus levels in plasma and urine

Barba, Sonia Valdivieso; Kirschbaum, Clemens; Gao, Wei

doi:10.1016/j.biopsycho.2023.108541

Cited by 10 publications

(6 citation statements)

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“…The observation needs to be confirmed in a larger cohort with stringent preanalytical procedures and consideration of circadian rhythms and last food intake, which might impact on endocannabinoid levels [77,78]. Interestingly, PEA concentrations in hair were found to be positively associated with perceived stress [79], which was not observed for plasma PEA in the present study, but PEA was positively associated with BMI which was significantly affected by perceived stress, particularly in men (Figure 1). Young men and men at 51+ years perceived high stress only if the BMI was high, whereas the overall stress peak for men was at 40 years.…”

Section: Discussionmentioning

confidence: 47%

Sex, age, body mass index, and contraceptive use but not perceived stress influence healthy plasma lipidomic profiles

Hahnefeld,

Hackel,

Trautmann

et al. 2024

Preprint

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Background The stress of everyday life is thought to contribute to the pathogenesis of metabolic, vascular, mental, and immune diseases, with different susceptibilities in women and men. We hypothesized that sex differences in stress perception may manifest in sex-dependent lipid profiles. Methods The present study investigated the effect of sex, age, body mass index, perceived stress, regular and occasional drug use, and dietary supplements on plasma lipidomic profiles, obtained by mass spectrometry analyses. The study included 217 healthy women and 108 healthy men aged 18–68 years, who were recruited in a 2:1 female:male ratio to account for women with/without contraceptives. Results As expected, dehydroepiandrosterone sulfate (DHEAS) and ceramides were higher in men than in women, and in both sexes DHEAS decreased with age, while ceramides increased. Contrary to expectations, neither DHEAS nor ceramides were associated with perceived stress (PSQ30 questionnaire), which peaked in young and 51 + women (low in ages between), and in obese young men, whereas the overall male PSQ30 peak was around 40 years of age. None of the lipid species or classes showed a similar "age X sex X BMI" interaction. Strong sex differences were found for lysophosphatidylcholines (LPCs) (low in women) and their metabolites, lysophosphatidic acids (LPAs) (high in women). The LPA:LPC ratio was particularly high in women receiving contraceptives suggesting a strong hormone-induced conversion of LPCs to LPAs via autotaxin, which was much higher in women than in men, and is known to trigger platelet aggregation. In addition, phosphatidylethanolamines (PE) were high in women. They are precursors of endocannabinoids such as palmitoylethanolamide (PEA), which was elevated in subjects with a medical history of hypertension and increased with the BMI. Conclusion The results reveal complex sex differences in perceived stress and lipidomic profiles, the latter being exacerbated by contraceptive use, but perceived stress and lipids were not directly correlated. Trial registration Not applicable

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Section: Discussionmentioning

confidence: 47%

Sex, age, body mass index, and contraceptive use but not perceived stress influence healthy plasma lipidomic profiles

Hahnefeld,

Hackel,

Trautmann

et al. 2024

Preprint

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“…Moreover, reported findings might also be related to phasic vs. tonic eCB/NAE release in the brain, which may be further supported by our null results of the correlation analyses between plasma and hair levels of eCBs/NAEs after FDR-correction (see supplementary materials Table S6). No association between hair and plasma eCB/NAE levels have been also recently reported [81].…”

Section: Discussionmentioning

confidence: 92%

Plasma endocannabinoids in cocaine dependence and their interaction with cocaine craving and metabotropic glutamate receptor 5 density in the human brain

Kroll

Hulka

Kexel

et al. 2023

Preprint

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Animal models indicate that the endocannabinoid system (ECS) plays a modulatory role in stress and reward processing, both crucially impaired in addictive disorders. Preclinical findings showed endocannabinoid-modulated synaptic plasticity in reward brain networks linked to the metabotropic-glutamate-5 receptor (mGluR5), contributing to drug-reinforcing effects and drug-seeking behavior. Although animal models postulate a link between ECS and cocaine addiction, human translational studies are lacking. Here, we tested previous preclinical findings by investigating plasma endocannabinoids (eCBs) anandamide (AEA), 2-arachidonoylglycerol (2-AG), and the related N-acylethanolamines (NAEs) palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), including their interaction with cerebral mGluR5, in chronic cocaine users (CU). We compared basal plasma concentrations between chronic CU (N=103; 69 recreational CU and 34 dependent CU) and stimulant-naive healthy controls (N=92). Follow-up basal eCB/NAE plasma levels after 12 months were used for reliability and stability check (CU: N=33; controls: N=43). In an additional analysis using 11C-ABP688 positron emission tomography (PET) in a male subsample (CU: N=18; controls: N=16), we investigated the relationships between eCBs/NAEs and mGluR5 density in the brain. We found higher 2-AG plasma levels in dependent CU compared to controls and recreational CU. 2-AG levels were stable over time across all groups. In the PET-subsample, a positive association between 2-AG and mGluR5 brain density only in CU was found. Our results corroborate animal findings suggesting an alteration of the ECS in cocaine dependence and an association between peripheral 2-AG levels and cerebral mGluR5 in humans. Therefore, the ECS might be a promising pharmaco-therapeutic target for novel treatments of cocaine dependence.

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“…Moreover, as the present investigation is longitudinal, batch effects present a complication 94 that may also affect biomarker concentrations in hair samples 8 , which we statistically controlled for in absolute stability analyses. Furthermore, it remains to be determined what peripheral EC/NAE levels measured in hair samples exactly reflect in terms of ECS functioning, as a first investigation found no significant link with blood and urine EC/NAE levels 95 . Also, while this study focused specifically on examining stability and inter-family relations of hair ECs/NAEs across the perinatal period, future investigations should examine in detail which psychological factors (e.g., traumatic experiences, depressive and anxiety symptoms) could explain variance in hair EC/NAE levels in this time.…”

Section: Discussionmentioning

confidence: 98%

Stability and inter-family associations of hair endocannabinoid and N-acylethanolamines across the perinatal period in mothers, fathers, and children

Bergunde,

Steudte-Schmiedgen,

Karl

et al. 2024

Sci Rep

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Analysis of endocannabinoids (ECs) and N-acylethanolamines (NAEs) in hair is assumed to retrospectively assess long-term EC/NAE concentrations. To inform their use, this study investigated stability of EC/NAE hair concentrations in mothers, fathers, and their children across the perinatal period as well as associations between family members. In a prospective cohort study, EC (AEA, 1-AG/2-AG) and NAE (SEA, PEA, OEA) levels were quantified in hair samples taken four times in mothers (n = 336) and their partners (n = 225) from pregnancy to two years postpartum and in offspring (n = 319) from shortly after birth to two years postpartum. Across the perinatal period, maternal and paternal hair ECs/NAEs showed poor multiple-test consistency (16–36%) and variable relative stability, as well as inconsistent absolute stability for mothers. Regarding children, hair ECs/NAEs evidenced poor multiple-test consistency (4–19%), no absolute stability, and either no or variable relative stability. Hair ECs/NAEs showed small to medium significant associations across the perinatal period within couples and parent–child dyads. Findings suggest hair ECs/NAEs during the perinatal period possess variable stability in adults, albeit more stability in fathers than mothers in this time. This highlights the need to further investigate factors associated with changes in hair ECs/NAEs across time. The first two years of life may be a dynamic phase for the endocannabinoid system in children, potentially characterized by complex within-family correspondence that requires further systematic investigation.

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Endocannabinoid and perceived stress: Association analysis of endocannabinoid levels in hair versus levels in plasma and urine

Cited by 10 publications

References 46 publications

Sex, age, body mass index, and contraceptive use but not perceived stress influence healthy plasma lipidomic profiles

Sex, age, body mass index, and contraceptive use but not perceived stress influence healthy plasma lipidomic profiles

Plasma endocannabinoids in cocaine dependence and their interaction with cocaine craving and metabotropic glutamate receptor 5 density in the human brain

Stability and inter-family associations of hair endocannabinoid and N-acylethanolamines across the perinatal period in mothers, fathers, and children

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