Endocan in prediabetes, diabetes, and diabetes-related complications: a systematic review and meta-analysis

Khalaji, Amirmohammad; Behnoush, Amir Hossein; Saeedian, Behrad; Khanmohammadi, Shaghayegh; Varniab, Zahra Shokri; Peiman, Soheil

doi:10.1186/s13098-023-01076-z

Cited by 11 publications

(6 citation statements)

References 63 publications

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“…Importantly, the strict association discussed throughout this study between the TyG index and HF outcomes underscores the potential role of IR in the pathogenesis of HF [57]. Indeed, IR is a well-recognized factor with multiple noxious effects, including endothelial dysfunction, oxidative stress, and myocardial remodeling, all contributing to impaired cardiac function and the development and progression of HF [33,58,59].…”

Section: Discussionmentioning

confidence: 58%

Triglyceride-glucose index and heart failure: a systematic review and meta-analysis

Khalaji,

Behnoush,

Khanmohammadi

et al. 2023

Cardiovasc Diabetol

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Background Insulin resistance (IR) is a major metabolic disorder observed in heart failure (HF) and is tightly associated with patients’ poor prognosis. The triglyceride-glucose index (TyG) has been proposed as a surrogate marker of IR in HF. Yet, whether TyG is a reliable clinical marker is still under debate. Hence, we aimed to respond to this relevant question via a systematic review and meta-analysis of existing studies. Methods A systematic search was conducted in PubMed, Embase, Scopus, and Web of Science to find studies investigating the TyG index in patients with HF or its association with the incidence of HF. Adjusted hazard ratios (HR) and 95% confidence intervals (CI) were pooled through random-effect meta-analysis. HRs were calculated using TyG as a continuous variable (1 unit increase) and by comparing the group with the highest TyG to the lowest TyG group. Results Thirty studies, involving 772,809 participants, were included in this systematic review. Meta-analysis of seven studies comparing the highest-TyG to the lowest-TyG group showed a significantly increased risk of HF in the former group (HR 1.21, 95% CI 1.14 to 1.29, P < 0.01). The same result was found when pooling the HRs for a one-unit increase in the TyG index (HR 1.17, 95% CI 1.08 to 1.26). Similarly, a more elevated TyG index was associated with a higher incidence of HF in patients with type 2 diabetes or coronary artery disease. Additionally, the incidence of adverse events (readmission and mortality) in patients with HF was associated with TyG. Conclusion Our findings support the TyG index as a valuable marker to assess the risk of HF incidence in different populations and as a prognostic marker in patients with HF. Further studies should be conducted to confirm these associations and investigate the clinical utility of the TyG index.

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Section: Discussionmentioning

confidence: 58%

Triglyceride-glucose index and heart failure: a systematic review and meta-analysis

Khalaji,

Behnoush,

Khanmohammadi

et al. 2023

Cardiovasc Diabetol

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“…В нескольких исследованиях изучалась роль эндокана в качестве потенциального биомаркера при ИБС. Так, были отмечены более высокие концентрации эндокана в сыворотке крови у пациентов с хроническими формами ИБС в сравнении со здоровыми представителями контрольных групп [8,9], в том числе при наличии АГ [2], сахарного диабета [3,4] и синдрома ночного апноэ [16,23]. Также выявлено повышение его значений в группе пациентов с рестенозом коронарного стента [24].…”

Section: Discussionunclassified

“…[2]. Роль эндокана § изучена при многих заболеваниях, тесно связанных с воспалением и ЭД, таких как сахарный диабет 2 типа (СД2) [3,4], гипертония [5][6][7], атеросклеротические сердечно-сосудистые заболевания [2,[8][9][10], заболевания почек [11], ожирение [12,13], синдром поликистозных яичников [14], метаболический синдром [4], неалкогольная жировая болезнь печени [15], синдром ночного апноэ [16]. Учитывая известную взаимосвязь воспалительных и апоптотических процессов атерогенеза [17], представляется актуальным изучение взаимосвязи концентрации эндокана с уровнем маркеров апоптоза у пациентов с ишемической болезнью сердца (ИБС) в контексте их клинико-инструментальных характеристик.…”

Section: Introductionunclassified

“…ОРИГИНАЛЬНЫЕ СТАТЬИ § Захарьян Е. А.¹, Грицкевич О. Ю.¹, Ибрагимова Р. Э.², Григорьев П. Е. 3,4 1 Ордена Трудового Красного Знамени Медицинский институт им. С. И. Георгиевского ФГАОУ ВО «Крымский федеральный университет имени В. И. Вернадского», Симферополь, Россия 2 ФГБУ «НМИЦ им.…”

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“…С. И. Георгиевского ФГАОУ ВО «Крымский федеральный университет имени В. И. Вернадского», Симферополь, Россия 2 ФГБУ «НМИЦ им. В. А. Алмазова» Минздрава РФ, Санкт-Петербург, Россия 3 ФГАОУ ВО «Севастопольский государственный университет», Севастополь, Россия 4 ГБУЗ РК «Академический научно-исследовательский институт физических методов лечения, медицинской климатологии и реабилитации имени И. М. Сеченова», Ялта, Россия…”

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Correlation of Serum Endocan Level With Apoptosis Indicators and Severity of Atherosclerotic Lesions of Coronary Arteries in Patients With Coronary Heart Disease

Zakharyan,

Gritskevich,

Ibragimova

et al. 2023

Kardiologiia

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Aim To study the relationship of blood serum concentration of endocan with indexes of apoptosis and clinical and instrumental characteristics of patients with ischemic heart disease (IHD).Material and methods The study included 176 subjects (105 men and 71 women). 150 of them were diagnosed with IHD and 26 were healthy volunteers. Anthropometric measurements, coronary angiography, echocardiography, duplex ultrasound scanning of extracranial parts of the brachiocephalic arteries were performed for all patients. Concentrations of endocan (ng / ml), glucose (mmol / l), and apoptotic markers Bcl-2 (ng / ml), Bax (ng / ml), Bcl-2 / Bax, TRAIL (pg / ml), and p53 (ng / ml) were measured in blood serum. Patients were divided into groups based on their SYNTAX scores: group 1 with moderate atherosclerotic lesions of the coronary arteries (CA) (score < 22, 78 patients); group 2 with severe CA atherosclerosis (score 23-32, 37 patients); and group 3 with extremely severe CA lesions (score >33, 35 patients). The control group consisted of healthy volunteers (26 subjects). All groups were age- and sex-matched. Differences were considered statistically significant at p<0.05.Results A correlation was found between endocan concentration and IHD severity (r=0.32, p<0.001). In group 1, the median endocan concentration was 14.57 ng / ml [8.21; 23.66], in group 2, 19.34 ng / ml [8.425; 26.645], in group 3, 32.13 ng / ml [18.2; 39.12], and in the control group, 6.92 ng / ml [4.62; 9.18]. Correlations of varying strength and significance were observed between the endocan concentration and a number of clinical and instrumental characteristics. Endocan concentrations significantly differed in groups of patients with multifocal atherosclerosis (p<0.01), angina pectoris (p<0.01), a history of myocardial infarction (p<0.001), and obesity (p<0.05) from patients without these signs. Also, a correlation was found between serum endocan concentration and apoptotic markers: TRAIL (r= -0.448, p<0.001); BCL-2 (r= -0.552, p<0.001), Bax (r= -0.519, p<0.001), Bcl-2 / Bax (r= -0.576, p<0.001) and p53 (r= -0.520, p <0.001).Conclusion The study demonstrated a potential role of endocan as a promising biomarker for risk stratification, prognosis and therapeutic monitoring of IHD patients.

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Endocan as a biomarker for acute respiratory distress syndrome: A systematic review and meta‐analysis

Behnoush,

Khalaji,

Ghasemi

et al. 2024

Health Science Reports

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Background and AimsEndocan is a marker of endothelial damage. Data regarding the association of this proteoglycan and acute respiratory distress syndrome (ARDS) is discrepant. Hence, this study sought to investigate the possible correlation between serum/plasma endocan concentration and ARDS.MethodsA systematic review and meta‐analysis of international online databases was conducted following PRISMA guidelines. PubMed, SCOPUS, Embase, and Web of Science were searched in March 2023, with the leading search terms being “ARDS” OR “respiratory distress” AND “endocan” and other associated terms. Studies that measured endocan levels in patients with ARDS and compared it with non‐ARDS controls or within different severities of ARDS were included. We performed a random‐effect meta‐analysis for pooling the differences using standardized mean difference (SMD) and 95% confidence interval (CI).ResultsWe included 14 studies involving 1,058 patients. Those developing ARDS had significantly higher levels of endocan compared to those without ARDS (SMD: 0.47, 95% CI: 0.10–0.84, p = 0.01). Our meta‐analysis of three studies found that endocan levels in ARDS nonsurvivors were significantly higher than in survivors (SMD: 0.31, 95% CI: 0.02–0.60, p = 0.03). Three studies investigated endocan levels in different severities of ARDS. Only one of these studies reported significantly higher endocan levels in patients with worsening acute respiratory failure at Day 15. The other two reported no significant association between ARDS severity and circulating endocan levels.ConclusionBlood endocan levels were significantly higher in patients with ARDS than those without. Additionally, among patients with ARDS, blood endocan values were significantly elevated in nonsurvivors compared to survivors. These findings could help researchers design future studies and solidify these findings and finally, clinicians to take advantage of measuring endocan in clinical settings for assessment of patients with ARDS.

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Endocan in prediabetes, diabetes, and diabetes-related complications: a systematic review and meta-analysis

Cited by 11 publications

References 63 publications

Triglyceride-glucose index and heart failure: a systematic review and meta-analysis

Triglyceride-glucose index and heart failure: a systematic review and meta-analysis

Correlation of Serum Endocan Level With Apoptosis Indicators and Severity of Atherosclerotic Lesions of Coronary Arteries in Patients With Coronary Heart Disease

Endocan as a biomarker for acute respiratory distress syndrome: A systematic review and meta‐analysis

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