Endemic medicinal plants of Ethiopia: Ethnomedicinal uses, biological activities and chemical constituents

Ayalew, Hiwot; Tewelde, Eyael; Abebe, Besufekad; Alebachew, Yonatan; Tadesse, Solomon

doi:10.1016/j.jep.2022.115307

Cited by 14 publications

(13 citation statements)

References 106 publications

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“…The endemic plants of Ethiopia mainly comprise two listings. One list comprises 476 plant species and the other comprises 480 plant species ( Awas, 2009 ; Ayalew et al, 2022 ). But considering the International Species Names Index (IPNI) database, the list of endemic plants in Ethiopia has been reduced to 412 medicinal plant species.…”

Section: Resultsmentioning

confidence: 99%

“…Among these 64 endemic plants, 20 plants are used as medicinal plants by traditional healers. Hiwot et al reported that in Ethiopia, there are 44 endemic plants that are medicinally valuable and are used to treat an array of diseases ( Ayalew et al, 2022 ). In this study, there are 20 plants that are medicinally valuable, among which 15 has also been reported in the study done by Hiwot et al In addition to these 15 plants in the current study more five endemic plants i.e.…”

Section: Resultsmentioning

confidence: 99%

“…In the current study, the traditional healers have used the maximum number of medicinal plants belonging to the family of Asteraceae. Some of these plants are endemic and are being used extensively by the traditional healers in Ethiopia ( Ayalew et al, 2022 ). Among the 12 Asteraceae medicinal plants used by the healers, six of them have fidelity level ranging from 80 to 100 percent.…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, the essential oil of this plant exhibits anti-cancer activity against a variety of cell lines such as NB4, EACC, HL-60, HepG2 etc ( Gakuubi et al, 2016 ). Solanecio gigas (Vatke) C.Jeffrey is an endemic plant of Ethiopia and has been used to treat many diseases such as diarrhoea, wounds, skin and liver diseases ( Ayalew et al, 2022 ). As this plant is endemic to Ethiopia a very few studies have been carried out to characterize the pharmacological and bioactivities of this plant.…”

Section: Resultsmentioning

confidence: 99%

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Ethnobotanical study of endemic and non-endemic medicinal plants used by indigenous people in environs of Gullele botanical garden Addis Ababa, central Ethiopia: A major focus on Asteraceae family

et al. 2022

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Gullele Botanical Garden (GBG) in Addis Ababa, Ethiopia is a joint venture of Addis Ababa government and the university. The garden has been built mainly to conserve the endemic plants and to advance the research on the endemic and non-endemic plants collected from different part of Ethiopia. Many traditional healers from the environs of GBG and different subcities of Addis Ababa depend on the garden for their practice of traditional medicine but there is no systematic documentation of the traditional medicinal knowledge of these healers. The main objective of the present study is to comprehensively document the ethnobotanical and ethnomedicinal information from the traditional healers of different ethnic and cultural groups depending on GBG and to create a database of the endemic plants used by these healers. The ethnobotanical and ethnomedicinal data obtained from 60 traditional healers have been analyzed both qualitatively and quantitatively. A total of 81 medicinal plants belonging to 47 families have been identified. Majority of the plants used belonged to Asteraceae (12) family. The most frequently used plant form and plant parts are herbs and leaves. The major method adopted by the healers for preparation and administration of traditional medicine is crushing and topical, respectively. Skin and general diseases are the most important ailments treated by the healers. The three most cited plants used to treat diseases are Echinops kebericho Mesfin (60), Hagenia abyssinica (Bruce) J.F.Gmel (60) and Laggera tomentosa (A.Rich.) Sch.Bip. ex Oliv. & Hiern (58). The present study is the first systematic, qualitative, and quantitative ethnobotanical analysis and documentation done on the use of the medicinal plants from GBG for traditional medicine. In addition, our study reveals that E. kebericho is endemic and endangered plant and is highly used in traditional medicine. Therefore, GBG authorities should take steps for the propagation and restoration of this plant. Further it is suggested that the pharmacological properties of the roots and leaves of E. kebericho should be compared to find the possibility of use of leaves in place of roots for the preparation of traditional medicine which would help in conserving this endemic plant of Ethiopia.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Ethnobotanical study of endemic and non-endemic medicinal plants used by indigenous people in environs of Gullele botanical garden Addis Ababa, central Ethiopia: A major focus on Asteraceae family

et al. 2022

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“…Dengan kata lain tumbuhan maupun hewan memiliki keanekaragaman yang khas dan hanya ditemukan pada daerah dengan lahan kering beriklim kering. Suatu Tumbuhan dapat dikategorikan endemik apabila keberadaannya unik pada suatu wilayah dan tidak ditemukan di wilayah lain secara alami (Ayalew et al, 2022;Neo et al, 2021). Istilah endemik juga biasa diterapkan pada unit geografi suatu pulau atau kelompok pulau atau kadang-kadang berupa Negara, tipe habitat atau wilayah.…”

Section: Pendahuluanunclassified

Identifikasi Dan Karakterisasi Senyawa Metabolit Sekunder Tumbuhan Endemik Asal Desa Fatunisuan Kabupaten Timor Tengah Utara

Sila

Masing

Santiari

2022

j. sains. teknologi.

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Desa Fatunisuan terletak dalam wilayah Kecamatan Miomafo Barat, Kabupaten Timor Tengah Utara, Provinsi Nusa Tenggara Timur yang identik dengan topografi berbukit-bukit dan terletak di dataran tinggi. Berdasarkan hasil riset, di Kecamatan Miomaffo Barat secara menyeluruh terdapat jenis tanaman jeruk keprok dan umbi-umbian. Riset khusus untuk mengidentifikasi dan menginventarisasi jenis tumbuhan endemik dan bemanfaat di Desa Fatunisuan belum pernah dilakukan hingga saat ini. Tujuan penelitian ini adalah untuk mengidentifikasi jenis tumbuhan endemik dan bermanfaat dari kelompok tumbuhan tingkat tinggi (phanerogamae) dan karakterisasi senyawa metabolit sekunder yang terkandung dalam ekstrak daun tumbuhan tersebut. Metode penelitian yang digunakan merupakan mix method antara eksplorasi dan eksperimen. Metode eksplorasi untuk mengidentifikasi jenis tumbuhan, dan metode eksperimen dengan uji skrining fitokimia untuk karakterisasi jenis senyawa metabolit sekunder. Hasil penelitian ini menunjukan bahwa di desa Fatunisuan terdapat tujuh jenis tumbuhan yang endemik dan bermanfaat bagi masyarakat desa setempat yakni Santalum album var. largifolium Rudjiman et Adrie, Santalum album L. var. album ziphus mauritiana, Pinus merkusii, Piper majusculum Blume, Coffea arabica, Arenga pinnata, dan Aleurites moluccana. Hasil karakterisasi jenis senyawa metabolit dari ke tujuh ekstrak daun tumbuhan tersebut dapat diketahui bahwa ekstrak daun Santalum album var. largifolium Rudjiman et Adrie maupun Santalum album L. var. album ziphus mauritiana dan ekstrak daun Coffea arabica memiliki kandungan lima jenis senyawa metabolit sekunder yaitu Alkaloid, Fenolik, Saponin, Flavanoid, dan Triterpenoid. Ekstrak pelepah daun Arenga pinnata maupun daun Aleurites moluccana memiliki kandungan lima jenis senyawa metabolit sekunder yaitu Alkaloid, Fenolik, Steroid, Saponin, dan Flavanoid. Sementara itu ekstrak daun Pinus merkusii memiliki kandungan enam jenis senyawa metabolit sekunder yang terdiri dari Alkaloid, Fenolik, Saponin, Flavanoid, Triterpenoid, dan Tanin. Sedangkan ekstrak daun Piper majusculum Blume memiliki kandungan lima jenis senyawa metabolit sekunder yaitu Alkaloid, Fenolik, Steroid, Saponin, dan Tanin

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Evaluation of antioxidant and antibacterial properties of dehydrocostus lactone isolated from Echinops kebericho root

Endalew,

Taddese,

Muhammed

2024

Health Science Reports

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Background and AimEchinops kebericho, an endemic plant to Ethiopia, traditionally used to treat infectious as well as noninfectious diseases. The primary objective of this study was isolating dehydrocostus lactone (DHCL) from E. kebericho and evaluating antibacterial activities on selected human pathogenic bacteria.MethodsExtraction method used in this study was maceration. Based on the bioassay information methanol extract of the root of E. kebericho was subjected to column chromatography on silica gel by increasing solvent gradients to isolate DHCL. Optimized amount isolation of DHCL was done by dissolving methanol crude extract by hexane followed by recrystallization at room temperature in the dark place. Different concentrations of the extract were subjected by disc diffusion method against tested bacterial species and antioxidant activity test.ResultsThe phytochemical analysis of E. kebericho revealed a high presence of terpenoids, which are diverse natural compounds known for their antimicrobial and antioxidant properties. This suggests that terpenoids contribute significantly to the pharmacological effects of E. kebericho. In antibacterial testing, Escherichia coli was the most sensitive bacterium among all extracts and concentrations. The methanol extract displayed higher antioxidant activity compared to ethyl acetate and hexane extracts, indicating a higher concentration of antioxidant compounds. Notably, the isolated compound DHCL showed promising activity against tested pathogens and significant antioxidant activity. The higher activity of DHCL compared to the crude extracts suggests its responsibility for the observed effects, indicating that the isolation and purification process may have concentrated its beneficial properties. These findings highlight the potential of E. kebericho and DHCL as sources of bioactive compounds for therapeutic applications.ConclusionAll tested extracts and pure compound showed higher inhibition than positive controls in both bioassay. DHCL the principal bioactive component in the root extract of the plant and it displayed potent antibacterial and antioxidant activity.

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Endemic medicinal plants of Ethiopia: Ethnomedicinal uses, biological activities and chemical constituents

Cited by 14 publications

References 106 publications

Ethnobotanical study of endemic and non-endemic medicinal plants used by indigenous people in environs of Gullele botanical garden Addis Ababa, central Ethiopia: A major focus on Asteraceae family

Ethnobotanical study of endemic and non-endemic medicinal plants used by indigenous people in environs of Gullele botanical garden Addis Ababa, central Ethiopia: A major focus on Asteraceae family

Identifikasi Dan Karakterisasi Senyawa Metabolit Sekunder Tumbuhan Endemik Asal Desa Fatunisuan Kabupaten Timor Tengah Utara

Evaluation of antioxidant and antibacterial properties of dehydrocostus lactone isolated from Echinops kebericho root

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