Encoding microcarriers for biomedicine

Abstract

High throughput biological analysis has become an important topic in modern biomedical research and clinical diagnosis. The flow encoding scheme based on the encoding microcarriers provides a feasible strategy for the multiplexed biological analysis. Different encoding characteristics invest the microcarriers with different encoding mechanisms. Biosensor analysis, drug screening, cell culture, and the construction and evaluation of bionic organ chips can be realized by decoding the microcarriers and quantifying the detection signal intensity. In this review, the encoding strategy of microcarriers was divided into the optical and non‐optical encoding approaches according to their encoding elements, and the research progress of the microcarrier encoding strategy was elaborated. Finally, we summarized the biomedical applications and predicted their future prospects.

Development of a concentration‐controlled sequential nanoprecipitation for making lipid nanoparticles with high drug loading

“…As demonstrated previously that high drug loading NPs exhibited enhanced cellular uptake and cytotoxicity in cancer cells, as well as improved anti-tumor efficacy with fewer side effects in mice models compared to low drug loading NPs, [7,20] future in vitro and in vivo studies will be conducted for these LNPs systems with high drug loading. Co-loading of two or multiple drugs would be beneficial for addressing some of the challenges facing combination therapy and other biomedical applications, [30,31] so future studies will be conducted for making LNPs with co-loading of dual or multiple drugs. Furthermore, stable LNP formulations need to be developed in future for their long-term storage, for example, through lyophilization.…”

Core–Shell Silica Nanoparticle-Based Barcodes Combined with a Hybridization Chain Reaction for Multiplex Quantitative Detection of Bacterial Drug-Resistance Genes

“…22,23 multiplex detection. 24 However, most of the PhC barcodes can provide inert surfaces only for biological reactions due to their single constituent materials and uniform structure. This limits the combination of advanced biotechnology with encoding carriers and the sensitivity of low-abundance biomolecular detection.…”

“…Therefore, they can have different structural colors as encoding elements by adjusting the size of the periodic nanostructure. PhCs possess excellent encoding stability since they do not suffer from photobleaching or fluorescence background interference. , Therefore, PhCs have been considered as excellent suspension encoding microcarriers employed in multiplex detection . However, most of the PhC barcodes can provide inert surfaces only for biological reactions due to their single constituent materials and uniform structure.…”

Targeting Adhesive Tumor Adventitia via Injectable Electrospun Short Fibers in Perfusion of Intraperitoneal Sporadic Tumors

“…Nowadays, many biomaterials have been reported to promote the application of chemotherapy, [16][17][18][19] among which, the group of Yoon Yeo reported a hydrogel depot of PTX nanocrystals for IPC and they proved it effective in treating peritoneal metastasis. [20,21] Nevertheless, no matter what it was, chemotherapy, hydrogel depot, or other biomaterials, such as liposomes, micelle, and dendrimer, they are unable to target tumors and release drugs locally.…”