Encircling Photothrombotic Therapy for Choroidal Greene Melanoma Using Rose Bengal

Evaluation of eye melanoma treatments in rabbits: A systematic review

“…Of these, 27 articles were included for the qualitative synthesis, with publication dates from 1970 to 2018. Of the selected studies, 19 used PDT as treatment, [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] six used radiotherapy [34][35][36][37][38][39] and two used laser. 40,41 No studies with surgical therapy that met the inclusion criteria were obtained.…”

“…Outcome of tumour therapy were evaluated by various methods, including biomicroscopy exams, 17,20,21,24,26,27,30,31,33,40,41 angiographic examination 15–19,21–24,26–28,31,33,40,41 histological examination, 15–23,26–28,30,31,33,34,36,37,40,41 fundoscopy, 18,19,22,23,27,28,32–34,38–41 magnetic spectroscopy, 38 electron microscopy, 24,29,35 ultrasound exam 18,…”

“…32,36 All treatments led to tumour inhibition. 18,19,23,32 However, complete tumour destruction was not always achieved, 15,17,22 with incomplete tumour necrosis 29 and tumour development in the periphery of the treated area. 16,27 It was demonstrated absence of tumour growth after PDT, 31 occurring irreversible regression, 26 and tumour destruction.…”

“…33 No tumour cells were detected in the histological examination 21 and necrosis was present. 15–24,26–33 Radiotherapy is effective, destroying melanoma. 36 Since the height of the tumour may influence its complete regression, 34 partial 38,39 to total responses were observed at varying periods of days after treatment, 37 with necrosis areas of variable dimensions.…”

“…16,17,31 Interruption of surrounding choroidal vasculature 22 inflammatory process, 20 hyperaemia 16,29 and choroid atrophy. 27,33 Retinal oedema, 16,20,22,28,32,33 haemorrhage, 18,22,27,32,33 detachment 18,19,22,25,27,28,32,33 and necrosis. 25,28 Scars 18,25 and chorioretinal atrophy.…”

Evaluation of eye melanoma treatments in rabbits: A systematic review

“…Of these, 27 articles were included for the qualitative synthesis, with publication dates from 1970 to 2018. Of the selected studies, 19 used PDT as treatment, [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] six used radiotherapy [34][35][36][37][38][39] and two used laser. 40,41 No studies with surgical therapy that met the inclusion criteria were obtained.…”

“…Outcome of tumour therapy were evaluated by various methods, including biomicroscopy exams, 17,20,21,24,26,27,30,31,33,40,41 angiographic examination 15–19,21–24,26–28,31,33,40,41 histological examination, 15–23,26–28,30,31,33,34,36,37,40,41 fundoscopy, 18,19,22,23,27,28,32–34,38–41 magnetic spectroscopy, 38 electron microscopy, 24,29,35 ultrasound exam 18,…”

“…32,36 All treatments led to tumour inhibition. 18,19,23,32 However, complete tumour destruction was not always achieved, 15,17,22 with incomplete tumour necrosis 29 and tumour development in the periphery of the treated area. 16,27 It was demonstrated absence of tumour growth after PDT, 31 occurring irreversible regression, 26 and tumour destruction.…”

“…33 No tumour cells were detected in the histological examination 21 and necrosis was present. 15–24,26–33 Radiotherapy is effective, destroying melanoma. 36 Since the height of the tumour may influence its complete regression, 34 partial 38,39 to total responses were observed at varying periods of days after treatment, 37 with necrosis areas of variable dimensions.…”

“…16,17,31 Interruption of surrounding choroidal vasculature 22 inflammatory process, 20 hyperaemia 16,29 and choroid atrophy. 27,33 Retinal oedema, 16,20,22,28,32,33 haemorrhage, 18,22,27,32,33 detachment 18,19,22,25,27,28,32,33 and necrosis. 25,28 Scars 18,25 and chorioretinal atrophy.…”

Evaluation of eye melanoma treatments in rabbits: A systematic review

“…Of these, 27 articles were included for the qualitative synthesis, with publication dates from 1970 to 2018. Of the selected studies, 19 used PDT as treatment, [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] six used radiotherapy [34][35][36][37][38][39] and two used laser. 40,41 No studies with surgical therapy that met the inclusion criteria were obtained.…”

“…Outcome of tumour therapy were evaluated by various methods, including biomicroscopy exams, 17,20,21,24,26,27,30,31,33,40,41 angiographic examination 15–19,21–24,26–28,31,33,40,41 histological examination, 15–23,26–28,30,31,33,34,36,37,40,41 fundoscopy, 18,19,22,23,27,28,32–34,38–41 magnetic spectroscopy, 38 electron microscopy, 24,29,35 ultrasound exam 18,…”

“…32,36 All treatments led to tumour inhibition. 18,19,23,32 However, complete tumour destruction was not always achieved, 15,17,22 with incomplete tumour necrosis 29 and tumour development in the periphery of the treated area. 16,27 It was demonstrated absence of tumour growth after PDT, 31 occurring irreversible regression, 26 and tumour destruction.…”

“…33 No tumour cells were detected in the histological examination 21 and necrosis was present. 15–24,26–33 Radiotherapy is effective, destroying melanoma. 36 Since the height of the tumour may influence its complete regression, 34 partial 38,39 to total responses were observed at varying periods of days after treatment, 37 with necrosis areas of variable dimensions.…”

“…16,17,31 Interruption of surrounding choroidal vasculature 22 inflammatory process, 20 hyperaemia 16,29 and choroid atrophy. 27,33 Retinal oedema, 16,20,22,28,32,33 haemorrhage, 18,22,27,32,33 detachment 18,19,22,25,27,28,32,33 and necrosis. 25,28 Scars 18,25 and chorioretinal atrophy.…”

Evaluation of eye melanoma treatments in rabbits: A systematic review

“…Of these, 27 articles were included for the qualitative synthesis, with publication dates from 1970 to 2018. Of the selected studies, 19 used PDT as treatment, [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] six used radiotherapy [34][35][36][37][38][39] and two used laser. 40,41 No studies with surgical therapy that met the inclusion criteria were obtained.…”

“…Outcome of tumour therapy were evaluated by various methods, including biomicroscopy exams, 17,20,21,24,26,27,30,31,33,40,41 angiographic examination 15–19,21–24,26–28,31,33,40,41 histological examination, 15–23,26–28,30,31,33,34,36,37,40,41 fundoscopy, 18,19,22,23,27,28,32–34,38–41 magnetic spectroscopy, 38 electron microscopy, 24,29,35 ultrasound exam 18,…”

“…32,36 All treatments led to tumour inhibition. 18,19,23,32 However, complete tumour destruction was not always achieved, 15,17,22 with incomplete tumour necrosis 29 and tumour development in the periphery of the treated area. 16,27 It was demonstrated absence of tumour growth after PDT, 31 occurring irreversible regression, 26 and tumour destruction.…”

“…33 No tumour cells were detected in the histological examination 21 and necrosis was present. 15–24,26–33 Radiotherapy is effective, destroying melanoma. 36 Since the height of the tumour may influence its complete regression, 34 partial 38,39 to total responses were observed at varying periods of days after treatment, 37 with necrosis areas of variable dimensions.…”

“…16,17,31 Interruption of surrounding choroidal vasculature 22 inflammatory process, 20 hyperaemia 16,29 and choroid atrophy. 27,33 Retinal oedema, 16,20,22,28,32,33 haemorrhage, 18,22,27,32,33 detachment 18,19,22,25,27,28,32,33 and necrosis. 25,28 Scars 18,25 and chorioretinal atrophy.…”