Encapsulation of vitamin B12 into nanoengineered capsules and soft matter nanosystems for targeted delivery

Maiorova, Larissa A.; Erokhina, Svetlana; Pisani, Michela; Barucca, G.; Marcaccio, Massimo; Койфман, О. И.; Salnikov, Denis S.; Громова, О. А.; Astolfi, Paola; Ricci, Valentina; Erokhin, Victor

doi:10.1016/j.colsurfb.2019.110366

Cited by 35 publications

(27 citation statements)

References 61 publications

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“…Nanocarriers in the pharmaceutical application have been developed to avoid nonspecific distribution and uncontrolled release of drugs that occurs in conventional administration. Targeted delivery of VitB12 is a major focus of modern prescriptions: for instance, conveying the vitamin to the bone marrow and nerve cells is currently a pharmacological challenge for myelin recovery [66].…”

Section: Nanotechnologies and Vitb12mentioning

confidence: 99%

“…The latter are obtained using colloidal CaCO 3 as templates for the shell formation, containing alternate layers of poly(allylamine hydrochloride) (conjugated with tetra-methylrhodamine isothiocyanate) and poly(sodium 4-styrene sulfonate). Obtained particles were left in a VitB12 solution to accomplish the load of vitamin [66].…”

Section: Nanotechnologies and Vitb12mentioning

confidence: 99%

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Current Nanocarrier Strategies Improve Vitamin B12 Pharmacokinetics, Ameliorate Patients’ Lives, and Reduce Costs

et al. 2021

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Vitamin B12 (VitB12) is a naturally occurring compound produced by microorganisms and an essential nutrient for humans. Several papers highlight the role of VitB12 deficiency in bone and heart health, depression, memory performance, fertility, embryo development, and cancer, while VitB12 treatment is crucial for survival in inborn errors of VitB12 metabolism. VitB12 is administrated through intramuscular injection, thus impacting the patients’ lifestyle, although it is known that oral administration may meet the specific requirement even in the case of malabsorption. Furthermore, the high-dose injection of VitB12 does not ensure a constant dosage, while the oral route allows only 1.2% of the vitamin to be absorbed in human beings. Nanocarriers are promising nanotechnology that can enable therapies to be improved, reducing side effects. Today, nanocarrier strategies applied at VitB12 delivery are at the initial phase and aim to simplify administration, reduce costs, improve pharmacokinetics, and ameliorate the quality of patients’ lives. The safety of nanotechnologies is still under investigation and few treatments involving nanocarriers have been approved, so far. Here, we highlight the role of VitB12 in human metabolism and diseases, and the issues linked to its molecule properties, and discuss how nanocarriers can improve the therapy and supplementation of the vitamin and reduce possible side effects and limits.

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Section: Nanotechnologies and Vitb12mentioning

confidence: 99%

Section: Nanotechnologies and Vitb12mentioning

confidence: 99%

Current Nanocarrier Strategies Improve Vitamin B12 Pharmacokinetics, Ameliorate Patients’ Lives, and Reduce Costs

et al. 2021

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“…Finally, while all the examples discussed in this review refer to nematic LCs, XRD techniques can provide fundamental structural information on many other LC systems, such as lyotropic LCs [ 86 , 87 , 88 , 89 , 90 , 91 , 92 ], novel chiral LC phases [ 93 , 94 , 95 ], LC polymers [ 96 , 97 ], colloidal LCs [ 98 , 99 , 100 ], etc.…”

Section: Discussionmentioning

confidence: 99%

Nanostructure of Unconventional Liquid Crystals Investigated by Synchrotron Radiation

et al. 2020

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The macroscopic properties of novel liquid crystal (LC) systems—LCs with unconventional molecular structure as well as conventional LCs in unconventional geometries—directly descend from their mesoscopic structural organization. While X-ray diffraction (XRD) is an obvious choice to investigate their nanoscale structure, conventional diffractometry is often hampered by experimental difficulties: the low scattering power and short-range positional order of the materials, resulting in weak and diffuse diffraction features; the need to perform measurements in challenging conditions, e.g., under magnetic and/or electric fields, on thin films, or at high temperatures; and the necessity to probe micron-sized volumes to tell the local structural properties from their macroscopic average. Synchrotron XRD allows these problems to be circumvented thanks to the superior diffraction capabilities (brilliance, q-range, energy and space resolution) and advanced sample environment available at synchrotron beamlines. Here, we highlight the potentiality of synchrotron XRD in the field of LCs by reviewing a selection of experiments on three unconventional LC systems: the potentially biaxial and polar nematic phase of bent-core mesogens; the very high-temperature nematic phase of all-aromatic LCs; and polymer-dispersed liquid crystals. In all these cases, synchrotron XRD unveils subtle nanostructural features that are reflected into macroscopic properties of great interest from both fundamental and technological points of view.

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“…[ 1 , 2 , 3 , 4 ]. More recently, cubosome and hexosome systems, in which the lipid bilayers are arranged in periodic two and three dimensional lattice structures, represent attractive smart delivery matrices for drugs and/or diagnostic agents with different water affinity [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. The latter structures have received increasing attention due to their properties, such as size, structure, and stability; ability to be tuned by their internal composition, polymer concentration, and processing conditions; and their ability to accommodate relatively large loads (drug or proteins).…”

Section: Introductionmentioning

confidence: 99%

Synchrotron Characterization of Hexagonal and Cubic Lipidic Phases Loaded with Azolate/Phosphane Gold(I) Compounds: A New Approach to the Uploading of Gold(I)-Based Drugs

et al. 2020

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Gold(I) phosphane compounds have recently attracted a renewed interest as potential new protagonists in cancer therapy. A class of phosphane gold(I) complexes containing azolate ligands has been successfully tested against several cancer cell lines and, in particular, against basal-like breast (BLB) cancer, a form characterized by strongly severe diagnosis and short life lapse after classic chemotherapy. Even though the anticancer activity of gold(I) phosphane compounds is thoroughly ascertained, no study has been devoted to the possibility of their delivery in nanovectors. Herein, nonlamellar lyotropic liquid crystalline lipid nanosystems, a promising class of smart materials, have been used to encapsulate gold(I) azolate/phosphane complexes. In particular, ((triphenylphosphine)-gold(I)-(4,5-dichloroimidazolyl-1H-1yl)) (C-I) and ((triphenylphosphine)-gold(I)-(4,5-dicyanoimidazolyl-1H-1yl)) (C-II) have been encapsulated in three different lipid matrices: monoolein (GMO), phytantriol (PHYT) and dioleoyl-phosphatidylethanolamine (DOPE). An integrated experimental approach involving X-ray diffraction and UV resonant Raman (UVRR) spectroscopy, based on synchrotron light and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, has been employed to establish the effects of drug encapsulation on the structure and phase behavior of the host mesophases. The results indicate that gold(I) complexes C-I and C-II are successfully encapsulated in the three lipid matrices as evidenced by the drug-induced phase transitions or by the changes in the mesophase lattice parameters observed in X-ray diffraction experiments and by the spectral changes occurring in UV resonant Raman spectra upon loading the lipid matrices with C-I and C-II.

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Encapsulation of vitamin B12 into nanoengineered capsules and soft matter nanosystems for targeted delivery

Cited by 35 publications

References 61 publications

Current Nanocarrier Strategies Improve Vitamin B12 Pharmacokinetics, Ameliorate Patients’ Lives, and Reduce Costs

Current Nanocarrier Strategies Improve Vitamin B12 Pharmacokinetics, Ameliorate Patients’ Lives, and Reduce Costs

Nanostructure of Unconventional Liquid Crystals Investigated by Synchrotron Radiation

Synchrotron Characterization of Hexagonal and Cubic Lipidic Phases Loaded with Azolate/Phosphane Gold(I) Compounds: A New Approach to the Uploading of Gold(I)-Based Drugs

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