Encapsulation of flaxseed oil in the tertiary conjugate of oxidized tannic acid-gelatin and flaxseed (Linum usitatissimum) mucilage

Mohseni, Farzaneh Aziz; Goli, Sayed Amir Hossein

doi:10.1016/j.ijbiomac.2019.08.197

Cited by 38 publications

(12 citation statements)

References 31 publications

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“…Although the cross-linked alginate-ion gel is known as a biocompatible and bioactive network with unique cell adhesion properties, it has disadvantages, such as limited durability in physiological conditions, which affects the swelling behavior and release of the drug [44][45][46]59,60]. The prepared composite gel was loaded with LOH, an extract employed in diverse medicine for its biologically active compounds [36,37,61,62]. According to Wang et al, several intermolecular cross-links may be formed through Ca 2+ between nHA and Alg, LOH and Alg, and nHA and LOH due to the divalent nature of Ca ions [35].…”

Section: Discussionmentioning

confidence: 99%

“…In LOH FTIR spectra, the C-H symmetrical and asymmetrical stretching vibration in CH 2 and CH 3 groups are revealed at around 2920 and 2848 cm −1 , while their bending vibrations are located at 1487 and 1450 cm −1 . The peaks at about 1650 cm −1 are related to carbonyl (C=O) groups and at near 1263, 1076, and 1030 cm −1 are due to C-O and C-C stretching vibrations [36][37][38]. FTIR spectrum of nanocomposite gel contains all absorbance peaks of Alg, LOH, and nHA, with some shifts and overlapping in the intensity and/or shape of the absorption peaks.…”

Section: Ftir Spectroscopymentioning

confidence: 99%

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Fabrication and Characterization of Nanocomposite Hydrogel Based on Alginate/Nano-Hydroxyapatite Loaded with Linum usitatissimum Extract as a Bone Tissue Engineering Scaffold

et al. 2021

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In the current paper, we fabricated, characterized, and applied nanocomposite hydrogel based on alginate (Alg) and nano-hydroxyapatite (nHA) loaded with phenolic purified extracts from the aerial part of Linum usitatissimum (LOH) as the bone tissue engineering scaffold. nHA was synthesized based on the wet chemical technique/precipitation reaction and incorporated into Alg hydrogel as the filler via physical cross-linking. The characterizations (SEM, DLS, and Zeta potential) revealed that the synthesized nHA possess a plate-like shape with nanometric dimensions. The fabricated nanocomposite has a porous architecture with interconnected pores. The average pore size was in the range of 100–200 µm and the porosity range of 80–90%. The LOH release measurement showed that about 90% of the loaded drug was released within 12 h followed by a sustained release over 48 h. The in vitro assessments showed that the nanocomposite possesses significant antioxidant activity promoting bone regeneration. The hemolysis induction measurement showed that the nanocomposites were hemocompatible with negligible hemolysis induction. The cell viability/proliferation confirmed the biocompatibility of the nanocomposites, which induced proliferative effects in a dose-dependent manner. This study revealed the fabricated nanocomposites are bioactive and osteoactive applicable for bone tissue engineering applications.

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Section: Discussionmentioning

confidence: 99%

Section: Ftir Spectroscopymentioning

confidence: 99%

Fabrication and Characterization of Nanocomposite Hydrogel Based on Alginate/Nano-Hydroxyapatite Loaded with Linum usitatissimum Extract as a Bone Tissue Engineering Scaffold

et al. 2021

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“…NO-TA provided stronger intermolecular connectivity via hydrogen bonding and enhanced mechanical and gelling properties compared to OX-TA cross-linked coacervates [212]. In contrast, Mohseni et al [213] found improved oxidative stability of flaxseed oil microcapsules cross-linked with OX-TA. In addition to tannic acids, coffee and white grape juice have also been shown to have sufficient phenolic content, which can be directly used in cross-link formation without isolating active compounds [214].…”

Section: Phenolics As Cross-linkers In Complex Coacervationmentioning

confidence: 94%

Seaweed Phenolics as Natural Antioxidants, Aquafeed Additives, Veterinary Treatments and Cross-Linkers for Microencapsulation

et al. 2022

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Driven by consumer demand and government policies, synthetic additives in aquafeed require substitution with sustainable and natural alternatives. Seaweeds have been shown to be a sustainable marine source of novel bioactive phenolic compounds that can be used in food, animal and aqua feeds, or microencapsulation applications. For example, phlorotannins are a structurally unique polymeric phenolic group exclusively found in brown seaweed that act through multiple antioxidant mechanisms. Seaweed phenolics show high affinities for binding proteins via covalent and non-covalent bonds and can have specific bioactivities due to their structures and associated physicochemical properties. Their ability to act as protein cross-linkers means they can be used to enhance the rheological and mechanical properties of food-grade delivery systems, such as microencapsulation, which is a new area of investigation illustrating the versatility of seaweed phenolics. Here we review how seaweed phenolics can be used in a range of applications, with reference to their bioactivity and structural properties.

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“…A tertiary conjugate was fabricated using FM, gelatin, and oxidized tannic acid [ 56 , 57 ], and it was found that the complex (FM–gelatin–oxidized tannic acid) could be used for the protection of oxidation-sensitive food ingredients and controlled release of bioactives in delivery systems in the food industry. A tertiary conjugate of gelatin–FM–oxidized tannic acid (OTA) was used (as wall material) to encapsulate flaxseed oil (which has a high amount of unsaturation) [ 56 ]. It is well known that, compared with saturated oils, oils with a high degree of unsaturation are highly susceptible to oxidation.…”

Section: Food Applications Of Fm/fgmentioning

confidence: 99%

A Review of Extraction Techniques and Food Applications of Flaxseed Mucilage

Puligundla

Lim

2022

Foods

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Flaxseed contains significant concentration of mucilage or gum (a type of hydrocolloid). Flaxseed mucilage (FM) predominantly occurs in the outermost layer of the seed’s hull and is known to possess numerous health benefits such as delayed gastric emptying, reduced serum cholesterol, and improved glycemic control. FM is typically composed of an arabinoxylan (neutral in nature) and a pectic-like material (acidic in nature). Similar to gum arabic, FM exhibits good water-binding capacity and rheological properties (similar functionality); therefore, FM can be used as its replacement in foods. In this review, an overview of methods used for FM extraction and factors influencing the extraction yield were discussed initially. Thereafter, food applications of FM as gelling agent/gel-strengthening agent, structure-forming agent, stabilizing agent, fat replacer, anti-retrogradation agent, prebiotic, encapsulating agent, edible coatings and films/food packaging material, and emulsifier/emulsion stabilizer were included. At the end, some limitations to its wide application and potential solutions were added.

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Encapsulation of flaxseed oil in the tertiary conjugate of oxidized tannic acid-gelatin and flaxseed (Linum usitatissimum) mucilage

Cited by 38 publications

References 31 publications

Fabrication and Characterization of Nanocomposite Hydrogel Based on Alginate/Nano-Hydroxyapatite Loaded with Linum usitatissimum Extract as a Bone Tissue Engineering Scaffold

Fabrication and Characterization of Nanocomposite Hydrogel Based on Alginate/Nano-Hydroxyapatite Loaded with Linum usitatissimum Extract as a Bone Tissue Engineering Scaffold

Seaweed Phenolics as Natural Antioxidants, Aquafeed Additives, Veterinary Treatments and Cross-Linkers for Microencapsulation

A Review of Extraction Techniques and Food Applications of Flaxseed Mucilage

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