Encapsulation of clozapine in polymeric nanocapsules and its biological effects

Łukasiewicz, Sylwia; Szczepanowicz, Krzysztof; Podgórna, Karolina; Błasiak, Ewa; Majeed, Nather; Ögren, Sven Ove; Nowak, Witold; Warszyński, Piotr; Dziedzicka-Wasylewska, Marta

doi:10.1016/j.colsurfb.2015.12.044

Cited by 36 publications

(25 citation statements)

References 47 publications

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“…Polymeric nanoparticles can not only modulate the pharmacokinetic properties of various active substances due to the subcellular size of nanoparticles, but also affect biocompatibility and/or biodegradability of polymers employed to produce the nanoparticles. Depending on their internal structure, polymeric nanoparticles may be further classified as nanospheres or nanocapsules [16]. As suggested by the name, a polymeric nanosphere has usually a regular sphere structure, which is composed of a solid polymeric matrix.…”

Section: Introductionmentioning

confidence: 99%

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell. This is of increasing interest in drug delivery applications. In this review, nanocapsules delivery systems studied in last decade are reviewed, along with nanocapsule formulation, characterizations of physical/chemical/biologic properties and applications. Furthermore, the challenges and opportunities of nanocapsules applications are also proposed.

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Section: Introductionmentioning

confidence: 99%

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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“…Oil-in-water nanoemulsions (O/W) exhibit a great ability to carry large quantities of hydrophobic substances in the dispersed phase and protect them from degradation. Such emulsions consist of oil droplets coated by thin polymer shells and suspended in an aqueous medium [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ], so they can also be treated as dispersions of nanocapsules. They may serve as carriers of corrosion inhibitors, pesticides, and antimicrobial agents [ 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

et al. 2020

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Recent developments in the fabrication of core-shell polymer nanocapsules, as well as their current and future applications, are reported here. Special attention is paid to the newly introduced surfactant-free fabrication method of aqueous dispersions of nanocapsules with hydrophobic liquid cores stabilized by amphiphilic copolymers. Various approaches to the efficient stabilization of such vehicles, tailoring their cores and shells for the fabrication of multifunctional, navigable nanocarriers and/or nanoreactors useful in various fields, are discussed. The emphasis is placed on biomedical applications of polymer nanocapsules, including the delivery of poorly soluble active compounds and contrast agents, as well as their use as theranostic platforms. Other methods of fabrication of polymer-based nanocapsules are briefly presented and compared in the context of their biomedical applications.

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“…Nanocapsules were synthesized as described previously (Karabasz et al 2014 ; Łukasiewicz et al 2016 ; Piotrowski et al 2013 , 2015 ; Szczepanowicz et al 2010b , 2014 , 2015 ). The hydrophobic phase for nanocapsules’ core preparation was formulated by the dissolution of surface-active agent AOT in chloroform (330 mg/ml).…”

Section: Methodsmentioning

confidence: 99%

Nanocapsules with Polyelectrolyte Shell as a Platform for 1,25-dihydroxyvitamin D3 Neuroprotection: Study in Organotypic Hippocampal Slices

et al. 2016

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Calcitriol (1,25-dihydroxyvitamin D3), an active metabolite of vitamin D3, besides the role in calcium and phosphorus metabolism, plays a role in maintaining the functions of the brain. Active forms of vitamin D3 stimulate neurotrophic factors’ expression, regulate brain immune processes, and prevent neuronal damage. Therefore, a potential utility of vitamin D3 in a therapy of neurodegenerative disorders should be taken into account. On the other hand, systemic vitamin D3 treatment carries the risk of undesirable effects, e.g., hypercalcemia. Thus, 1,25-dihydroxyvitamin D3 targeting delivery by nanoparticles would be a tremendous advancement in treatment of brain disorders. Calcitriol was enclosed in emulsion-templated nanocapsules with different polymeric shells: PLL (Poly(l-lysine hydrobromide)), PLL/PGA (/Poly(l-glutamic acid)), and PLL/PGA-g-PEG (Poly(l-glutamic acid) grafted with polyethylene glycol). The average size of all synthesized nanocapsules ranged from −80 to −100 nm. Biocompatibilities of synthesized nanocarriers were examined in hippocampal organotypic cultures in basal conditions and after treatment with lipopolysaccharide (LPS) using various biochemical tests. We demonstrated that nanocapsules coated with PLL were toxic, while PLL/PGA- and PLL/PGA-g-PEG-covered ones were nontoxic and used for further experiments. Our study demonstrated that in LPS-treated hippocampal slices, both types of loaded nanoparticles have protective ability. Our findings underlined that the neuroprotective action of vitamin D3 in both free and nanoparticle forms seems to be related to the suppression of LPS-induced nitric oxide release.

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Encapsulation of clozapine in polymeric nanocapsules and its biological effects

Cited by 36 publications

References 47 publications

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

Nanocapsules with Polyelectrolyte Shell as a Platform for 1,25-dihydroxyvitamin D3 Neuroprotection: Study in Organotypic Hippocampal Slices

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