Encapsulation of an endostatin peptide in liposomes: Stability, release, and cytotoxicity study

Rezaei, Nastaran; Mehrnejad, Faramarz; Vaezi, Zahra; Sedghi, Mosslim; Asghari, S. Mohsen; Naderi-Manesh, Hossein

doi:10.1016/j.colsurfb.2019.110552

Cited by 41 publications

(21 citation statements)

References 52 publications

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“…Since the loading of the peptides influences the arrangement of the liposome membrane (Sarabandi et al, 2019). However, A10F3 liposomes showed lower PDI even when compared to the control liposome, indicating that these liposomal peptides are relatively monodisperse and the distribution size is quite thin and reliable (Pinilla et al, 2019;Rezaei et al, 2020).…”

Section: Particle Size and Pdimentioning

confidence: 99%

“…Besides, some authors report that the bioactivity of these peptides is also influenced by the amino acid residues present in the C-terminal and N-terminal of the peptide sequence (Saiga et al, 2006;Zhang et al, 2010). In this sense, the protection of the peptide sequence terminals is reported as necessary to preserve the bioactivity of the peptides, since these compounds have a relatively high chemical reactivity and can undergo modifications, either through degradation processes or during gastrointestinal digestion, causing a reduction in its functionality (Marín-Peñalver et al, 2019;Mohan et al, 2015;Rezaei et al, 2020).…”

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confidence: 99%

“…Encapsulation is considered an effective technique for trapping bioactive compounds within a polymeric material for protection and controlled delivery (Rezaei et al, 2020). Encapsulation processes ensure greater stability to bioactive compounds, can be used to solubilize hydrophobic compounds in water-based foods, stabilizing reactive compounds, and protecting them from adverse reactions in the medium as an effective barrier (de Freitas Zômpero et al, 2015;Ray et al, 2016).…”

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confidence: 99%

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Nanoencapsulation of white shrimp peptides in liposomes: Characterization, stability, and influence on bioactive properties

Latorres

Aquino

Rocha

et al. 2021

J. Food Process. Preserv.

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Bioactive peptides are low-molecular-weight protein fractions with amino acid sequences that can promote various biological activities. These are compounds typically obtained through the cleavage of peptide bonds via enzymatic hydrolysis, fermentative processes, or food processing (Liu et al., 2020). Besides high biological activity, these compounds have stable structures, which allow the digestive epithelial barrier to cross and reach blood vessels (Shabestarian et al., 2016).Among the physiological activities presented by such peptide compounds, anti-hypertensive and antioxidant bioactivity stand

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Section: Particle Size and Pdimentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Nanoencapsulation of white shrimp peptides in liposomes: Characterization, stability, and influence on bioactive properties

Latorres

Aquino

Rocha

et al. 2021

J. Food Process. Preserv.

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“…Liposomal nanoparticles have various advantages such as increasing cellular uptake of the drugs, stabilizing physicochemicals, and the bioavailability of respective water-soluble or poorly water-soluble drugs which were significantly explored over the last decade for the drug delivery applications [17]. Electrostatic repulsion, steric repulsion, and strong hydration could affect liposomal stability [18,19]. Particle size and zeta potential are the two most important properties that determine the fate of intravenously injected liposomes.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronan-Loaded Liposomal Dexamethasone–Diclofenac Nanoparticles for Local Osteoarthritis Treatment

Chang

Chiang

Kuo

et al. 2021

IJMS

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Osteoarthritis (OA) remains one of the common degenerative joint diseases and a major cause of pain and disability in older adult individuals. Oral administration of non-steroidal anti-inflammatory drugs (NSAIDs) (such as diclofenac, DIC) or intra-articular injected gluco-corticosteroids (such as dexamethasone, DEX) were the conventional treatment strategies for OA to reduce joint pain. Current limitations for both drugs including severe adverse effects with risks of toxicity were noted. The aim of the present study was to generate a novel OA treatment formulation hyaluronic acid (HA)-Liposomal (Lipo)-DIC/DEX to combat joint pain. The formulation was prepared by constructing DIC with DEX-loaded nanostructured lipid carriers Lipo-DIC/DEX mixed with hyaluronic acid (HA) for prolonged OA application. The prepared Lipo-DIC/DEX nanoparticles revealed the size as 103.6 ± 0.3 nm on average, zeta potential as −22.3 ± 4.6 mV, the entrapment efficiency of 90.5 ± 5.6%, and the DIC and DEX content was 22.5 ± 4.1 and 2.5 ± 0.6%, respectively. Evidence indicated that HA-Lipo-DIC/DEX could reach the effective working concentration in 4 h and sustained the drug-releasing time for at least 168 h. No significant toxicities but increased cell numbers were observed when HA-Lipo-DIC/DEX co-cultured with articular chondrocytes cells. Using live-animal In vivo imaging system (IVIS), intra-articular injection of each HA-Lipo-DIC/DEX sufficed to reduce knee joint inflammation in OA mice over a time span of four weeks. Single-dose injection could reduce the inflammation volume down to 77.5 ± 5.1% from initial over that time span. Our results provided the novel drug-releasing formulation with safety and efficiency which could be a promising system for osteoarthritis pain control.

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“…Одним из компонентов системы ингибирования ангиогенеза является эндостатин, полипептид с молекулярной массой 20 кДа, представляющий собой С-терминальный фрагмент коллагена XVIII [20]. С момента открытия эндостатина в 1997 г. проведено немало исследований, посвященных изучению его антиан- гиогенных свойств [21][22][23]. Наряду с этим известны случаи прямого антионкогенного эффекта полипептида на раковые клетки различного происхождения [24][25][26][27][28].…”

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Analysis of the anticancer effect of endostatin on oral squamous cell carcinoma based on results of experimental studies

Tuguzbaeva¹,

Павлов²,

Еникеев³

2020

Zhurnal «Patologicheskaia Fiziologiia I Eksperimental`naia Terapiia»

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При плоскоклеточном раке полости рта основной причиной летальных исходов является метастазирование в регионарные лимфатические узлы. Злокачественный рост и формирование метастазов напрямую зависят от степени кровоснабжения первичного очага новообразования. Известно, что по мере прогрессирования опухолевый процесс сопровождается нарушением сбалансированной в норме системы регуляции ангиогенеза с превалированием уровня ангиогенных стимуляторов над ингибиторами. В связи с этим, использование антиангиогенных средств является патофизиологически обоснованным методом борьбы со злокачественным ростом. В обзоре обсуждаются данные доклинических исследований участия эндостатина, природного ингибитора ангиогенеза, в процессах подавления прогрессии и метастазирования плоскоклеточного рака челюстно-лицевой области. Проанализированы патогенетические механизмы ингибирования эндостатином опухолевого роста в экспериментальных моделях рака полости рта. Эндостатин можно рассматривать в качестве потенциального противоопухолевого средства для лечения данной нозологии. The main reason for cancer-associated mortality in patients with oral squamous cell carcinoma is metastatic spread to regional lymph nodes. It is known that the processes of malignant growth and metastasis are highly dependent on blood supply to the primary cancerous focus. The development of malignancy is accompanied by failure of the normally well-balanced system of angiogenesis regulation with prevalence of proangiogenic factors over inhibitors. Therefore, the use of angiogenic inhibitors is a pathophysiologically justified method aimed at suppression of cancer progression. This review presents reports of experimental studies on the role of endostatin, a natural inhibitor of angiogenesis, in processes of tumour shrinkage in squamous cell carcinoma of the maxillofacial region. The authors analysed pathogenic mechanisms of the anticancer effects exhibited by endostatin in preclinical models of oral malignancy. Endostatin can be regarded as a potential antitumor agent for the treatment of oral squamous cell carcinoma.

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Encapsulation of an endostatin peptide in liposomes: Stability, release, and cytotoxicity study

Cited by 41 publications

References 52 publications

Nanoencapsulation of white shrimp peptides in liposomes: Characterization, stability, and influence on bioactive properties

Nanoencapsulation of white shrimp peptides in liposomes: Characterization, stability, and influence on bioactive properties

Hyaluronan-Loaded Liposomal Dexamethasone–Diclofenac Nanoparticles for Local Osteoarthritis Treatment

Analysis of the anticancer effect of endostatin on oral squamous cell carcinoma based on results of experimental studies

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