2016
DOI: 10.1155/2016/4831524
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Abstract: Background and Aims. The use of bone marrow cells has been suggested as an alternative treatment for acute liver failure. In this study, we investigate the effect of encapsulated whole bone marrow cells in a liver failure model. Methods. Encapsulated cells or empty capsules were implanted in rats submitted to 90% partial hepatectomy. The survival rate was assessed. Another group was euthanized at 6, 12, 24, 48, and 72 hours after hepatectomy to study expression of cytokines and growth factors. Results. Whole b… Show more

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Cited by 4 publications
(12 citation statements)
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“…So, although liver regeneration is essential for survival, different works point to other factors that influence recovery, including the pace of regeneration [27]. In addition, other studies from our group also point to a positive impact in survival that is not directly linked to hepatocyte regeneration [12, 28]. Thus, it is suggested that BMMC improve survival through mechanisms other than enhancing hepatocyte proliferation.…”
Section: Discussionmentioning
confidence: 87%
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“…So, although liver regeneration is essential for survival, different works point to other factors that influence recovery, including the pace of regeneration [27]. In addition, other studies from our group also point to a positive impact in survival that is not directly linked to hepatocyte regeneration [12, 28]. Thus, it is suggested that BMMC improve survival through mechanisms other than enhancing hepatocyte proliferation.…”
Section: Discussionmentioning
confidence: 87%
“…Other studies, using surgical models of 90% PH, such as Liu and Chang (2006) [24] and Uribe-Cruz et al (2016) [12], also observed an increase in survival in animals treated with encapsulated cells, but both groups used encapsulated whole bone marrow cells, without separation of mononuclear cells.…”
Section: Discussionmentioning
confidence: 97%
“…To achieve our goals, we used samples of liver obtained from the study published by Uribe-Cruz et al 6 . Briefly, Wistar rats were submitted to 90%PH.…”
Section: Methodsmentioning
confidence: 99%
“…Cell therapy protocols with bone marrow-derived cells have shown promising results increasing the speed of hepatic regeneration [2][3][4] . The mechanism of action of these cells is not completely understood but different mechanisms have been suggested, including paracrine effects 3,5,6 . In a previous study from our group we have shown that encapsulated whole-bone marrow cells (WBM) increase 10-day survival after 90%HP in 50% when compared with the control group (5%) by decreasing the expression of liver regenerating factors 6 .…”
mentioning
confidence: 99%
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