Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2011.10.072 View full text
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Shih-Chieh Lee, Chun-Chi Wang, Pin-Chen Yang, Shou-Mei Wu

Abstract: The (±)-threo-methylphenidate ((±)-threo-MP) is widely used for treatment of attention-deficit hyperactivity disorder (ADHD). According to clinical evidence, (+)-threo-MP possesses higher potency than (-)-threo-MP. Due to ppb level in plasma, till now, none of the capillary electrophoresis (CE) methods have been able to provide adequate sensitivity for therapeutic (±)-threo-MP monitoring. In this study, a cyclodextrin-modified field-amplified sample stacking CE method (CD-FASS-CE) for enantioseparation of (±)-…

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