volume 6, issue 9, P2135-2138 1995
DOI: 10.1016/0957-4166(95)00283-u
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Abstract: The asymmetric ortho lithiation of benzaldehyde chromiumtricarbonyl complex is performed by in situ temporary protection of the aldehyde functionality with a chiral amide and BuLi as metallating agent. Reaction with an electrophile followed by acidic hydrolysis leads to the enantiomerically enriched ortho substituted benzaldehyde chromiumtricarbonyl complex