volume 16, issue 4, P328-333 1994
DOI: 10.1016/0141-0229(94)90175-9
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Shau-Wei Tsai, Hwa-Jou Wei

Abstract: Enantioselective esterification of naproxen, 2-(6-methoxy-2-naphthyl) propionic acid, was attempted by lipases in nearly anhydrous isooctane. The nature of the alcohol affects the reactivity and enantioselectivity of the lipase from Candida cylindracea. Alcohols containing a trimethylsilyl group are highly reactive and enantioselective to the S-isomer of the acid. An optimal temperature around 65 degrees C and an enzyme concentration less than 7 mg ml-1 were proposed to resolve the racemate, with trimethylsily…

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