Emulsion electrospun polylactic acid/Apocynum venetum nanocellulose nanofiber membranes with controlled sea buckthorn extract release as a drug delivery system

Abstract

Prolonging the duration of drug action and reducing toxicity play a vital role in wound administration as they reduce the chance of infection and decrease complications and cost. This study reports the natural antioxidant procyanidins extracted from sea buckthorn (SBT) and laboratory-manufactured Apocynum venetum cellulose nanofiber as core drugs. The sustained-release nanofiber membrane was prepared by electrospinning on polylactic acid/polyvinyl pyrrolidone nanofibers. High-performance liquid chromatography-mass spectrometry was used to identify the phenolic compounds in SBT extracts and confirmed the presence of procyanidins with a content of 0.0345 mg/g. The nanofiber membrane was characterized through transmission electron microscopy, encapsulation efficiency, in vitro drug-release study and antioxidant assay. The results indicated that the extracted procyanidins were successfully encapsulated in the core–sheath structure nanofibers, and the encapsulation efficiency of nanofiber membranes reached 83.84%. In vitro measurements of the delivery showed this core–sheath structure could significantly alleviate the drug burst release, which is followed by a linear and smooth release within 30 hours. Further tests showed that the removal efficiency of 2,2-diphenyl-1-picrylhydrazyl reached 88.62%, indicating that the membranes had high antioxidant activity. This work implies that the combination of Apocynum venetum nanocellulose and emulsion electrospun fibers has promising potential applications in tissue engineering or drug delivery.

Effect of Ionic and Non-Ionic Surfactant on Bovine Serum Albumin Encapsulation and Biological Properties of Emulsion-Electrospun Fibers

“…As a result, they obtained a release character dominated by the diffusion mechanism, which promoted wound healing [ 16 ]. Other applications include improving the solubility of poorly water-soluble drugs (such as probutol) by encapsulating them in PVA-based fibers in the presence of a surfactant (Polysorbate 80) [ 17 ], the incorporation of antioxidants (sea buckthorn) in PLA/apocynum venetum cellulose fibers [ 18 ] and in dual-sensitive drugs for antitumor treatment consisting of Ag/Au and the therapeutic drug silibinin in the core part [ 19 ].…”

Composition analysis and antioxidant activity evaluation of a high purity oligomeric procyanidin prepared from sea buckthorn by a green method

“…In recent years, procyanidins found in the berries of sea buckthorn have attracted the interest of researchers due to their unique biological activity, beneficial potency, and low toxicity ( Tkacz et al, 2021 ; Wang et al, 2020 ). According to available reports, methanol or ethanol were mainly used as solvents in the extraction of procyanidins ( Pagano et al, 2021 ).…”

Electrospun PVB/AVE NMs as mask filter layer for win-win effects of filtration and antibacterial activity

“…With the right extraction techniques, AVE can be blended with other materials and achieve more versatile composites. Cellulose nanofibres (CNFs), PLA/CNF films, and CNFs reinforced chitosan-based composite hydrogels are a few of the materials reported in the literature [ 32 , 33 ]. In this study, Apocynum venetum leaves were combined with polyvinyl butyral (PVB) to prepare a filter membrane material for mask filtration.…”