A middle-aged educated Manipuri male patient, father of six children presented with 3 years history of progressive generalized fatigue, loss of appetite, bodyache, progressive proximal muscle weakness, bed-ridden for the past 4 months, generalized body swelling along with increased frequency of micturation associated with thirst. There was also history of progressive loss of secondary sexual characters with loss of axillary and pubic hairs and decreasing frequency of shaving with loss of libido and erectile dysfunction for the last 6 months. He attributed these symptoms to his ill health. During the last 2 weeks, he developed productive cough with shortness of breath with orthopnea and with low grade fever. He also gave history of persistent backache and bone pain. Past medical history presented was hypertension for which he was regularly taking amlodipine 5 mg. daily and was under control; however he was drowsier on the same dose with postural symptoms, hence stopped for the last one month. No significant past history of head injury, chronic febrile illness, drug addiction. He is a non-smoker and non-alcoholic. On physical examination, patient was conscious, drowsy, mildly febrile, generalized anasarca, P=64/min, BP=90/60, scattered crackles B/L chest, DTJs depressed with no babinski's sign to suggest focal neurological deficit. Genital examination showed normal penile size with bilateral small (2ml by orchidometer), flabby testes with sparse pubic hairs (facial, axillary hairs were also sparse). Here we are reporting a case of severe hyponatremia with isolated primary hypogonadism and Central Diabetes Insipidus (CDI) since severe hyponatremia is commonly encountered in panhypopituitarism.