2004
DOI: 10.1016/j.idc.2004.07.002
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Abstract: There are no data from proper studies to answer whether it is necessary to include antibiotics that are active against atypical pneumonia agents as part of the empiric therapy of CAP. Until such data are available, clinical judgment and severity of the pneumonic illness are the best guides to empiric antimicrobial therapy.

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Cited by 12 publications
(10 citation statements)
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References 77 publications
(70 reference statements)
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“…Because doxycycline displays concentration-dependent killing kinetics at high dose, it may also be administered as a single daily dose of 400 mg (IV ⁄ PO) every 24 h as part of the 3-day loading regimen or as 200 mg (IV ⁄ PO) for completion of therapy. To the best of my knowledge, there has not been a therapeutic failure using doxycycline when administered with a loading regimen in treating even severe Legionella CAP [4][5][6][68][69][70][71][72][73][74][75][76].…”
Section: Doxycyclinementioning
confidence: 99%
“…Because doxycycline displays concentration-dependent killing kinetics at high dose, it may also be administered as a single daily dose of 400 mg (IV ⁄ PO) every 24 h as part of the 3-day loading regimen or as 200 mg (IV ⁄ PO) for completion of therapy. To the best of my knowledge, there has not been a therapeutic failure using doxycycline when administered with a loading regimen in treating even severe Legionella CAP [4][5][6][68][69][70][71][72][73][74][75][76].…”
Section: Doxycyclinementioning
confidence: 99%
“…Risk factors for CAP include advanced age, chronic obstructive pulmonary disease, renal insufficiency, congestive heart failure, malignancy, diabetes, and alcoholism [5]. The etiologic organism in CAP is undetermined in 50% of cases [6]. Some of the more common organisms that cause CAP and the radiographic appearances are discussed below.…”
Section: Community Acquiredmentioning
confidence: 99%
“…Mycoplasma pneumoniae is the most common pathogen of this group. It also is one of the most commonly identified agents in CAP and causes 20% to 30% of infections [6]. Mycoplasma is the smallest free-living culturable organism and shares some similarities with bacteria; however, it lacks a cell wall.…”
Section: Atypical Pneumoniamentioning
confidence: 99%
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“…We audited prescribing practices in the emergency department (ED), and over the first 24 h of care, to identify the problems with empiric antibiotic prescribing for adults with community‐acquired pneumonia that were likely to be of most clinical significance for the patient. We were particularly interested in the early provision of antibiotic coverage for the likely bacterial pathogens, selection of antibiotics to accommodate known patient allergies and early broad‐spectrum empiric antibiotics for the patients who were most severely ill, as recommended in recent guidelines 1–5 …”
Section: Introductionmentioning
confidence: 99%