Emotional eccrine sweating. A heritable disorder

James, W. D.

doi:10.1001/archderm.123.7.925

Cited by 22 publications

(15 citation statements)

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“…Perspiration in PPH patients is often aggravated by emotional stimuli such as excessive stress and anxiety [James et al, 1987;Sato et al, 1989b], and its degree is variable, ranging from slightly damp to severe dripping from the palm. Although there is no threat of life, PPH may considerably reduce quality-of-life and cause serious emotional and social problems, for which patients often receive endoscopic thoracic sympathectomy (ETS) [Kux, 1978].…”

Section: Introductionmentioning

confidence: 99%

Primary palmar hyperhidrosis locus maps to 14q11.2‐q13

Higashimoto¹,

Yoshiura²,

Hirakawa³

et al. 2006

American J of Med Genetics Pt A

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Primary palmar hyperhidrosis (PPH) is a unique disorder of unknown cause. It is characterized by excessive perspiration of the eccrine sweat gland in the palm, sole, and the axilla. It is presumed that PPH results from overactivation of the cholinergic sympathetic nerve or dysfunction of the autonomic nervous system. There have been no genetic studies on the disease. We performed a linkage analysis of 11 families including 42 affected and 40 unaffected members using genome-wide DNA polymorphic markers to identify the disease locus. Diagnosis of their PPH was made by direct inspection, interviewing and measurement of the sweating rate with perspirometer. Consequently, from data of three of the 11 families examined, the combined maximum two-point LOD scores of 3.08 and 3.16 (recombination fraction = 0) were obtained at the D14S283 and D14S264 loci, respectively, on chromosome 14q11.2-q13, under an assumption that two liability conditions depend on age. These regions were ruled out in eight other families. Haplotype analysis of the three families supported that one of the PPH locus is assigned at minimum to about a 6-cM interval between D14S1070 and D14S990 and at maximum to about a 30-cM interval between D14S1070 and D14S70. This is the first report of systemic mapping of the PPH locus.

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Section: Introductionmentioning

confidence: 99%

Primary palmar hyperhidrosis locus maps to 14q11.2‐q13

Higashimoto¹,

Yoshiura²,

Hirakawa³

et al. 2006

American J of Med Genetics Pt A

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“…Males and females are equally afflicted. 5,14,[16][17][18][19][20][21][22] A familial trait for HH has been described, 23,24 and it has been estimated that 40% of patients have a family history of excessive sweating. 5 Ethnic predispositions have also been implicated; 8,21 however, contrary to the series of Adar et al 8 in which HH was observed among Jews originating from North Africa, Yemen, and the Balkans, being dark people, the majority of the subjects reported by Borak et al 7 were of light complexion.…”

Section: Introductionmentioning

confidence: 99%

The treatment of primary palmar hyperhidrosis: A review

2000

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Primary palmar hyperhidrosis (HH) is a pathological condition of overperspiration caused by excessive secretion of the eccrine sweat glands, the etiology of which is unknown. This disorder affects a small but significant proportion of the young population all over the world. Neither systemic nor topical drugs have been found to satisfactorily alleviate the symptoms. Although the topical injection of botulinum has recently been reported to reduce the amount of local perspiration, long-term results are required before a definitive evaluation of this method can be made. Hypnosis, psychotherapy, and biofeedback have been beneficial in a limited-number of cases. While radiation achieves atrophy of the sweat glands, its detrimental effects prohibit its use. Iontophoresis has attained some satisfactory results but it has not been assessed long term. Percutaneous computed tomography-guided phenol sympathicolysis achieves excellent immediate results, but its long-term failure rate is prohibitive. Furthermore, percutaneous radiofrequency sympathicolysis may be an effective procedure, but its long-term results are not superior to surgical sympathectomy. On the other hand, surgical upper dorsal (T2-T3) sympathectomy achieves excellent long-term results and the thoracoscopic approach has supplanted the open procedures. Despite some sequelae, mainly in the form of neuralgia and compensatory sweating which cannot be predicted and may be distressing, surgical sympathectomy remains the best treatment for palmar hyperhidrosis.

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“…Review CME Schieman, Gelfand & Grondin with a-2-adrenergic agonists [31], nonsteroidal anti-inflammatories [32], calcium channel blockers [33], benzodiazepines, b blockers [34], spasmolytics and anticonvulsants [35]; however, their use cannot be widely recommended.…”

Section: Systemic Medicationsmentioning

confidence: 99%