Biochemical Pharmacology volume 79, issue 8, P1134-1140 2010 DOI: 10.1016/j.bcp.2009.12.006 View full text
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Wei Wang, Yue-ping Sun, Xin-zhi Huang, Min He, Yu-ying Chen, Gui-ying Shi, Hui Li, Jing Yi, Jian Wang

Abstract: Glutathione conjugation and transportation of glutathione conjugates of anticancer drugs out of cells are important for detoxification of many anticancer drugs. Inhibition of this detoxification system has recently been proposed as a strategy to treat drug-resistant solid tumors. Gallbladder carcinoma is resistant to many anticancer drugs, therefore, it is needed to develop a novel strategy for cancer therapy. In the present study, we tested the effect of emodin (1,3,8-trihydroxy-6-methylanthraquinone), a reac…

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