Current Opinion in Hematology volume 17, issue 6, P505-513 2010 DOI: 10.1097/moh.0b013e32833e5b18 View full text
Paolo F Caimi, Jane Reese, Zhenghong Lee, Hillard M Lazarus

Abstract: Purpose Multipotent mesenchymal stromal cells (MSCs) are rare cells resident in bone marrow and other organs capable of differentiating into mesodermal lineage tissues. MSCs possess immunomodulatory properties and have extensive capacity for ex vivo expansion. Early clinical studies demonstrated safety and feasibility of infusing autologous MSCs and suggested a role in enhancing engraftment after hematopoietic cell transplant (HCT). Subsequent pilot studies using allogeneic MSCs showed safety but contradicto…

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