Emerging Roles of Apolipoprotein E and Apolipoprotein A-I in the Pathogenesis and Treatment of Lung Disease

Yao, Xianglan; Gordon, Elizabeth M.; Figueroa, Debbie M.; Barochia, Amisha V.; Levine, Stewart J.

doi:10.1165/rcmb.2016-0060tr

Cited by 116 publications

(104 citation statements)

References 98 publications

(110 reference statements)

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“…have been already-ample evidence showing that the pathogenic ApoE leads to an abnormal response of microglia to amyloid deposition in the brain (34,36,38). Currently, there is no evidence indicating a causal link between ApoE polymorphism and lung fibrosis (39). However, given that organ fibrosis, including IPF, normally occurs in the aged population, much like most of the neurodegenerative diseases, we are certainly intrigued to undertake such an investigation in future studies.…”

Section: Discussionmentioning

confidence: 99%

Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution

Jiang¹,

Banerjee²,

Xie³

et al. 2020

JCI Insight

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Section: Discussionmentioning

confidence: 99%

Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution

Jiang¹,

Banerjee²,

Xie³

et al. 2020

JCI Insight

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“…ApoE interacts with the low-density lipoprotein receptor (LDLR) to mediate the transport of cholesterol-and triglyceride-rich lipoprotein particles into cells via receptor-mediated endocytosis [27]. In contrast, apoAI is the major protein constituent of high-density lipoprotein (HDL) that mediates reverse cholesterol transport out of cells.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, apoAI is the major protein constituent of high-density lipoprotein (HDL) that mediates reverse cholesterol transport out of cells. ApoE and apoA1 are synthesized primarily in the liver but can also be expressed by lung cells where they help attenuate inflammation, oxidative stress, and tissue remodeling responses, while augmenting adaptive immunity and host defense [27]. ApoE receptor 2, one of the LDLR family members expressed in macrophages, can bind to its ligand apoE, exhibiting an anti-inflammatory role in atherosclerosis [27].…”

Section: Discussionmentioning

confidence: 99%

“…ApoE and apoA1 are synthesized primarily in the liver but can also be expressed by lung cells where they help attenuate inflammation, oxidative stress, and tissue remodeling responses, while augmenting adaptive immunity and host defense [27]. ApoE receptor 2, one of the LDLR family members expressed in macrophages, can bind to its ligand apoE, exhibiting an anti-inflammatory role in atherosclerosis [27]. Additional evidence suggests that apoE and C-reactive protein (CRP) are negatively related [28].…”

Section: Discussionmentioning

confidence: 99%

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Proteomics-Based Detection of Immune Dysfunction in an Elite Adventure Athlete Trekking Across the Antarctica

Nieman

Groen²,

Pugachev³

et al. 2020

Proteomes

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Proteomics monitoring of an elite adventure athlete (age 33 years) was conducted over a 28-week period that culminated in the successful, solo, unassisted, and unsupported two month trek across the Antarctica (1500 km). Training distress was monitored weekly using a 19-item, validated training distress scale (TDS). Weekly dried blood spot (DBS) specimens were collected via fingerprick blood drops onto standard blood spot cards. DBS proteins were measured with nano-electrospray ionization liquid chromatography tandem mass spectrometry (nanoLC-MS/MS) in data-independent acquisition (DIA) mode, and 712 proteins were identified and quantified. The 28-week period was divided into time segments based on TDS scores, and a contrast analysis between weeks five and eight (low TDS) and between weeks 20 and 23 (high TDS, last month of Antarctica trek) showed that 31 proteins (n = 20 immune related) were upregulated and 35 (n = 17 immune related) were downregulated. Protein–protein interaction (PPI) networks supported a dichotomous immune response. Gene ontology (GO) biological process terms for the upregulated immune proteins showed an increase in regulation of the immune system process, especially inflammation, complement activation, and leukocyte mediated immunity. At the same time, GO terms for the downregulated immune-related proteins indicated a decrease in several aspects of the overall immune system process including neutrophil degranulation and the antimicrobial humoral response. These proteomics data support a dysfunctional immune response in an elite adventure athlete during a sustained period of mental and physical distress while trekking solo across the Antarctica.

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“…Apo-A1 has been proved to be associated with many cancer, furthermore, it could be used as a potential biomarker for detection and diagnosis for many cancers such as bladder cancer [15,16]. In a recent study, researchers observed that lower serum levels of Apo-A1 in thyroid cancer patients compared to healthy controls, indicating that Apo-A1 may play an anti-tumor role in thyroid cancer [17].…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein A1 is A Protective Factor for Male Papillary Thyroid Cancer Patients. A Cross-Sectional Study of Single Academic Center in China.

Wang

Zhan-qiang

et al. 2020

Preprint

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Background: Papillary thyroid cancer (PTC) is the most common type of thyroid cancer and the incidence of PTC has continued to increase over the past decades. Many studies have shown that obesity is an independent risk factor for PTC and obese PTC patients tend to have a relative larger tumor size and higher grade of tumor stage. Obesity is associated with disordered lipid metabolism and the relationship between serum lipids and PTC remains unclear. Therefore, this study aimed to investigate the association between serum lipid level and PTC.Methods: We retrospectively analyzed 1018 PTC patients diagnosed and treated in our hospital, all these cases were first diagnosed with PTC and had complete clinical information including ultrasound reports before surgery, serum lipid (CHOL, TG, HDL-c, LDL-c, Apo-A1, Apo-B, Apo-E) results, surgical records and pathological reports. Results: None of these lipid markers were associated with tumor size in the whole cohort and in the female group. In the male group, on crude analysis, Apo-A1 showed a marginally significant association with tumor size, [OR=0.158 (0.021-1.777)], p=0.072. After adjusting for age and multifocality, Apo-A1 showed a significant association with tumor size [OR=0.126 (0.016-0.974)], p=0.047. This association become more apparent in a young male subgroup, [OR=0.051 (0.005-0.497)], p=0.009. CHOL, TG, HDL-c, LDL-c, Apo-B, Apo-E did not show significant association with tumor size. As for LNM, neither in the male group nor in the female group were found to be associated with any serum lipid biomarkers.Conclusion: As PTC incidences continues to increase, our finding a negative association between PTC and apoA-1 imply that these lipids are protective factors for male PTC patients and provide us new clues about PTC and lipid metabolism, which may contribute to further investigation concerning diagnosing and preventing this most common type of thyroid cancer.

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Emerging Roles of Apolipoprotein E and Apolipoprotein A-I in the Pathogenesis and Treatment of Lung Disease

Abstract: Emerging roles are being recognized increasingly for

Cited by 116 publications

References 98 publications

Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution

Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution

Proteomics-Based Detection of Immune Dysfunction in an Elite Adventure Athlete Trekking Across the Antarctica

Apolipoprotein A1 is A Protective Factor for Male Papillary Thyroid Cancer Patients. A Cross-Sectional Study of Single Academic Center in China.

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