Emerging role of lymphatic vessels in reverse cholesterol transport

Veronique, Angeli; Lim, Poh Ying

doi:10.18632/aging.100570

Cited by 2 publications

(2 citation statements)

References 8 publications

(2 reference statements)

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“…Based on this rationale, we and others have hypothesized that obesity-induced lymphatic dysfunction augments inflammatory responses, thereby amplifying the pathology of obesity in other organ systems 18 19 . This hypothesis is also supported by recent studies demonstrating that lymphatic function critically contributes to reverse cholesterol transport and that animals with abnormal lymphatics are more prone to developing atherosclerotic lesions 19 20 21 .…”

supporting

confidence: 54%

Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity

Torrisi

Hespe

Cuzzone

et al. 2016

Sci Rep

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Although recent studies have shown that obesity decreases lymphatic function, the cellular mechanisms regulating this response remain unknown. In the current study, we show that obesity results in perilymphatic accumulation of inflammatory cells and that local inhibition of this response with topical tacrolimus, an inhibitor of T cell differentiation, increases lymphatic vessel density, decreases perilymphatic iNOS expression, increases lymphatic vessel pumping frequency, and restores lymphatic clearance of interstitial fluid to normal levels. Although treatment of obese mice with 1400W, a selective inhibitor of iNOS, also improved lymphatic collecting vessel contractile function, it did not completely reverse lymphatic defects. Mice deficient in CD4+ cells fed a high fat diet also gained weight relative to controls but were protected from lymphatic dysfunction. Taken together, our findings suggest that obesity-mediated lymphatic dysfunction is regulated by perilymphatic accumulation of inflammatory cells and that T cell inflammatory responses are necessary to initiate this effect.

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supporting

confidence: 54%

Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity

Torrisi

Hespe

Cuzzone

et al. 2016

Sci Rep

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“…Accumulation of lipids in the extracellular tissues is the key feature of hypercholesterolemia. Recent studies have shown that the lymphatic system plays an important role in cholesterol metabolism by transporting cholesterol from the peripheral tissues to the liver via a process called RCT (Lim et al, 2013;Martel et al, 2013;Veronique and Ying, 2013;Huang et al, 2015). Studies using Chy mice or surgical ligation of lymphatic channels results in decreased RCT and cholesterol clearance from the tissues (Lim et al, 2013;Martel et al, 2013).…”

Section: Lymphatic Function In Hypercholesterolemia and MImentioning

confidence: 99%

Regulation of Lymphatic Function in Obesity

et al. 2020

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The lymphatic system has many functions, including macromolecules transport, fat absorption, regulation and modulation of adaptive immune responses, clearance of inflammatory cytokines, and cholesterol metabolism. Thus, it is evident that lymphatic function can play a key role in the regulation of a wide array of biologic phenomenon, and that physiologic changes that alter lymphatic function may have profound pathologic effects. Recent studies have shown that obesity can markedly impair lymphatic function. Obesity-induced pathologic changes in the lymphatic system result, at least in part, from the accumulation of inflammatory cells around lymphatic vessel leading to impaired lymphatic collecting vessel pumping capacity, leaky initial and collecting lymphatics, alterations in lymphatic endothelial cell (LEC) gene expression, and degradation of junctional proteins. These changes are important since impaired lymphatic function in obesity may contribute to the pathology of obesity in other organ systems in a feedforward manner by increasing low-grade tissue inflammation and the accumulation of inflammatory cytokines. More importantly, recent studies have suggested that interventions that inhibit inflammatory responses, either pharmacologically or by lifestyle modifications such as aerobic exercise and weight loss, improve lymphatic function and metabolic parameters in obese mice. The purpose of this review is to summarize the pathologic effects of obesity on the lymphatic system, the cellular mechanisms that regulate these responses, the effects of impaired lymphatic function on metabolic syndrome in obesity, and the interventions that may improve lymphatic function in obesity.

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Emerging role of lymphatic vessels in reverse cholesterol transport

Cited by 2 publications

References 8 publications

Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity

Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity

Regulation of Lymphatic Function in Obesity

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