Emerging Role of Folate-Mediated One Carbon Metabolism in Leukemia: A Review
Jinan Thabit,
Anwar Almzaiel
Abstract:Leukemia is a type of cancer that develops in the bone marrow and blood cells. When the DNA of a cell undergoes one mutation or a series of mutations results in the formation of leukemia cells. These leukemia cells, "blasts," cannot mature into fully functioning WBCs. Leukemia increases WBCs which compete for space with RBCs and platelets that the body requires to function normally; each may be classified as acute or chronic, myeloid or lymphoid, depending on the originating cell and the growth rate. Nearly 2.… Show more
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