Emerging Role of Antioxidants in the Protection of Uveitis Complications

Yadav, Umesh C.S.; Kalariya, Nilesh; Ramana, Kota V.

doi:10.2174/092986711794927694

Cited by 60 publications

(18 citation statements)

References 164 publications

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“…Also, those endogenous oxygen species generated into the eyes can induce ROS-related ocular disorders, as mentioned earlier. OS processes have been associated with a wide variety of eye diseases, such as ocular surface diseases,21 cataracts,22 glaucoma,23 uveitis,33 retinopathies, and AMD 25,26,28,33,34. All of these pathologies are related to age, which is in agreement with the Harman theory of FRs in aging 11…”

Section: Aging Eyes As Targets Of Oxidative Stresssupporting

confidence: 73%

Oxidative stress and its downstream signaling in aging eyes

Pinazo-Durán¹,

Gallego-Pinazo²,

García-Medina³

et al. 2014

CIA

105

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BackgroundOxidative stress (OS) and its biomarkers are the biochemical end point of the imbalance between reactive oxygen species (ROS) production and the ability of the antioxidant (AOX) biological systems to fight against oxidative injury.ObjectiveWe reviewed the role of OS and its downstream signaling in aging eyes.MethodsA search of the literature and current knowledge on the physiological and pathological mechanisms of OS were revisited in relation to the eyes and the aging process. Most prevalent ocular diseases have been analyzed herein in relation to OS and nutraceutic supplements, such as dry-eye disorders, glaucoma, age-related macular degeneration, and diabetic retinopathy.ResultsClinical, biochemical, and molecular data from anterior and posterior eye segment diseases point to OS as the common pathogenic mechanism in the majority of these ocular disorders, many of which are pathologies causing visual impairment, blindness, and subsequent loss of life quality. Studies with nutraceutic supplements in aging eye-related pathologies have also been reviewed.ConclusionOS, nutritional status, and nutraceutic supplements have to be considered within the standards of care of older ophthalmologic patients. OS biomarkers and surrogate end points may help in managing the aging population with ocular diseases.

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Section: Aging Eyes As Targets Of Oxidative Stresssupporting

confidence: 73%

Oxidative stress and its downstream signaling in aging eyes

Pinazo-Durán¹,

Gallego-Pinazo²,

García-Medina³

et al. 2014

CIA

105

View full text Add to dashboard Cite

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“…For example, Vitamin C and E, N-acetylcysteine (NAC), Lipoic acid, GSH, carotenoids and flavonoids from plants, and melatonins, have been shown to be effective in experimental models of many diseases including cardiovascular, neurodegenerative, infection, diabetic complications, autoimmune, and allergic complications. A number of antioxidants have undergone clinical trials [101–107] to prevent disease pathologies including cardiovascular and cancer. These antioxidants however have not been successfully translated for the clinical use because at the clinical doses they become prooxidants and result in serious side effects.…”

Section: Modulation Of Oxidative Stress and Lipid Aldehydes Signalmentioning

confidence: 99%

Regulation of NF-B-Induced Inflammatory Signaling by Lipid Peroxidation-Derived Aldehydes

Yadav

Ramana

2013

Oxidative Medicine and Cellular Longevity

159

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Oxidative stress plays a critical role in the pathophysiology of a wide range of diseases including cancer. This view has broadened significantly with the recent discoveries that reactive oxygen species initiated lipid peroxidation leads to the formation of potentially toxic lipid aldehyde species such as 4-hydroxy-trans-2-nonenal (HNE), acrolein, and malondialdehyde which activate various signaling intermediates that regulate cellular activity and dysfunction via a process called redox signaling. The lipid aldehyde species formed during synchronized enzymatic pathways result in the posttranslational modification of proteins and DNA leading to cytotoxicity and genotoxicty. Among the lipid aldehyde species, HNE has been widely accepted as a most toxic and abundant lipid aldehyde generated during lipid peroxidation. HNE and its glutathione conjugates have been shown to regulate redox-sensitive transcription factors such as NF-κB and AP-1 via signaling through various protein kinase cascades. Activation of redox-sensitive transcription factors and their nuclear localization leads to transcriptional induction of several genes responsible for cell survival, differentiation, and death. In this review, we describe the mechanisms by which the lipid aldehydes transduce activation of NF-κB signaling pathways that may help to develop therapeutic strategies for the prevention of a number of inflammatory diseases.

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“…Hydrogenium peroxide is the major oxidant involved in lens opacification and cataract formation. During uveitis, inflammation has a strong correlation with the oxidative stress [ 3 ]. In the uveitis eyes the presence of ROS causing protein and DNA modifications was demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress to the Cornea, Changes in Corneal Optical Properties, and Advances in Treatment of Corneal Oxidative Injuries

Čejka

Čejková

2015

Oxidative Medicine and Cellular Longevity

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Oxidative stress is involved in many ocular diseases and injuries. The imbalance between oxidants and antioxidants in favour of oxidants (oxidative stress) leads to the damage and may be highly involved in ocular aging processes. The anterior eye segment and mainly the cornea are directly exposed to noxae of external environment, such as air pollution, radiation, cigarette smoke, vapors or gases from household cleaning products, chemical burns from splashes of industrial chemicals, and danger from potential oxidative damage evoked by them. Oxidative stress may initiate or develop ocular injury resulting in decreased visual acuity or even vision loss. The role of oxidative stress in the pathogenesis of ocular diseases with particular attention to oxidative stress in the cornea and changes in corneal optical properties are discussed. Advances in the treatment of corneal oxidative injuries or diseases are shown.

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Emerging Role of Antioxidants in the Protection of Uveitis Complications

Cited by 60 publications

References 164 publications

Oxidative stress and its downstream signaling in aging eyes

Oxidative stress and its downstream signaling in aging eyes

Regulation of NF-B-Induced Inflammatory Signaling by Lipid Peroxidation-Derived Aldehydes

Oxidative Stress to the Cornea, Changes in Corneal Optical Properties, and Advances in Treatment of Corneal Oxidative Injuries

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