Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy

Zhang, Shenwu; Wang, Jing; Kong, Zhiqiang; Sun, Xinxin; Zhang, He; Sun, Bingjun; Luo, Cong; Sun, Jin

doi:10.1016/j.biomaterials.2022.121433

Cited by 136 publications

(95 citation statements)

References 153 publications

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“…Until now, nanomaterial-based phototherapy-induced ICD has been applied for treating both primary and metastatic tumors in vivo ( Wang Z. et al, 2019 ). In addition to ICD, such a nanosystem may also trigger the delivery of inhibitors, enzymes, adjuvants, and hydrogen sulfide to enhance the immunotherapeutic efficacy ( Han et al, 2017 ; Shi et al, 2018 ; Wang H. et al, 2019 ; Sun et al, 2021 ; Zhang et al, 2022 ). All of these examples indicate the great promise of nanomaterials in light-induced immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

Iodine-Rich Nanoadjuvants for CT Imaging–Guided Photodynamic Immunotherapy of Breast Cancer

Xin

Shi

et al. 2022

Front. Bioeng. Biotechnol.

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Immunotherapy, which stimulates the body’s own immune system to kill cancer cells, has shown great promise in the field of cancer therapy. However, the uncontrolled biodistribution of immunotherapeutic drugs may cause severe side effects. Herein, we report an iodine-rich nanoadjuvant (INA) for photo-immunotherapy. INA is prepared by encapsulating a toll-like receptor 7 agonist (R837) and a photosensitizer (phthalocyanine) into an iodine-rich amphiphilic copolymer PEG-PHEMA-I. By virtue of the enhanced permeation and retention (EPR) effect, INA can effectively accumulate into the tumor site. Under light irradiation, photodynamic therapy (PDT) triggered by INA will induce immunogenic cell death (ICD) in the tumor region to trigger the release of immune-associated cytokines. Such a process may further induce the maturation of dendritic cells which will be accelerated by R837, leading to the proliferation of effector T cells for immunotherapy. The photo-immunotherapy mediated by INA shows good anticancer efficacy both in vitro and in vivo. Meanwhile, INA is also a CT contrast agent owing to its high density of iodine, which can successfully illuminate tumors by CT imaging. Thus, our study develops a light-triggered nanoadjuvant for CT imaging–guided enhanced photo-immunotherapy.

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Section: Introductionmentioning

confidence: 99%

Iodine-Rich Nanoadjuvants for CT Imaging–Guided Photodynamic Immunotherapy of Breast Cancer

Xin

Shi

et al. 2022

Front. Bioeng. Biotechnol.

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“…According to the characteristics of TCM, studying the effect of TCM and its specific components on programmed tumor death, discovering effective anti-tumor components, and combining multi-disciplinary and multi-disciplinary approaches to target tumor sites by loading programmed death inducers, reactants of programmed death process, or TCM preparations through nanotechnology, so that drug concentrations accumulate at tumor sites, may bring new options for cancer treatment based on programmed death ( 178 , 180 , 181 ). The exploration of Chinese medicine to intervene in programmed death is still in its infancy, but there are already studies, showing extraordinary research prospects by loading Chinese medicine with nanotechnology for tumor treatment ( 182 ).…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer

Zhang

Liu

2022

Front. Immunol.

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Ovarian cancer (OC) is one of the most common malignancies that causes death in women and is a heterogeneous disease with complex molecular and genetic changes. Because of the relatively high recurrence rate of OC, it is crucial to understand the associated mechanisms of drug resistance and to discover potential target for rational targeted therapy. Cell death is a genetically determined process. Active and orderly cell death is prevalent during the development of living organisms and plays a critical role in regulating life homeostasis. Ferroptosis, a novel type of cell death discovered in recent years, is distinct from apoptosis and necrosis and is mainly caused by the imbalance between the production and degradation of intracellular lipid reactive oxygen species triggered by increased iron content. Necroptosis is a regulated non-cysteine protease–dependent programmed cell necrosis, morphologically exhibiting the same features as necrosis and occurring via a unique mechanism of programmed cell death different from the apoptotic signaling pathway. Pyroptosis is a form of programmed cell death that is characterized by the formation of membrane pores and subsequent cell lysis as well as release of pro-inflammatory cell contents mediated by the abscisin family. Studies have shown that ferroptosis, necroptosis, and pyroptosis are involved in the development and progression of a variety of diseases, including tumors. In this review, we summarized the recent advances in ferroptosis, necroptosis, and pyroptosis in the occurrence, development, and therapeutic potential of OC.

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“…The second-generation PSs are single compound synthesized, derived from porphyrin, bacteriochlorophyll, phthalocyanine, chlorin, benzoporphyrin, curcumin, methylene blue derivatives, etc., Compared with the first-generation PSs, the second-generation PSs have longer absorption spectrum (visible-near-infrared region), higher 1 O 2 yields, and better tumor targeting. For example, 5-aminolevulinic acid (5-ALA) has been successfully used in the treatment of basal cell carcinoma, actinic keratosis and oral premalignant disorder, Meso-tetrahydroxyphenyl chlorin (mTHPC-Foscan®) has been commonly used for advanced head and neck cancers ( Zhang S. et al, 2022 ). Other second-generation PSs that have received clinical approval or are in clinical trials include Temoporfin (Foscan®), Motexafin lutetium, Palladium bacteriopheophorbide, Purlytin®, Verteporfin (Visudyne®), and Talaporfin (Laserphyrin®) ( Baskaran et al, 2018 ).…”

Section: The Applications and The Photosensitizers For Clinical Tumor...mentioning

confidence: 99%

Progress of Nanomaterials in Photodynamic Therapy Against Tumor

Chen

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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Photodynamic therapy (PDT) is an advanced therapeutic strategy with light-triggered, minimally invasive, high spatiotemporal selective and low systemic toxicity properties, which has been widely used in the clinical treatment of many solid tumors in recent years. Any strategies that improve the three elements of PDT (light, oxygen, and photosensitizers) can improve the efficacy of PDT. However, traditional PDT is confronted some challenges of poor solubility of photosensitizers and tumor suppressive microenvironment. To overcome the related obstacles of PDT, various strategies have been investigated in terms of improving photosensitizers (PSs) delivery, penetration of excitation light sources, and hypoxic tumor microenvironment. In addition, compared with a single treatment mode, the synergistic treatment of multiple treatment modalities such as photothermal therapy, chemotherapy, and radiation therapy can improve the efficacy of PDT. This review summarizes recent advances in nanomaterials, including metal nanoparticles, liposomes, hydrogels and polymers, to enhance the efficiency of PDT against malignant tumor.

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Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy

Cited by 136 publications

References 153 publications

Iodine-Rich Nanoadjuvants for CT Imaging–Guided Photodynamic Immunotherapy of Breast Cancer

Iodine-Rich Nanoadjuvants for CT Imaging–Guided Photodynamic Immunotherapy of Breast Cancer

Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer

Progress of Nanomaterials in Photodynamic Therapy Against Tumor

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