The aim of the present study was to elucidate the microbial community metabolic profiles in saturated constructed wetland (CW) mesocosms planted with five different wetland plant species fed with water individually spiked with 100 μg L -1 ibuprofen or iohexol. Community-level physiological profiling (CLPP) using Biolog Ecoplates was performed and coupled with the assessment of water quality parameters (water temperature, pH, DO and TOC, TN, NH4-N, PO4-P removal efficiency). The microbial community metabolic profiles (microbial acitivity, richness, and carbon source utilization), as well as the water quality parameters revelead similar trends among the control mesocosms and the mescocosms fed with water spiked with iohexol and ibuprofen. Significant differences were observed between the planted and unplanted mesocosms and between seasons The corresponding author. a These authors contributed equally to this work.(summer and winter) within each of the feeding lines (control, iohexol or ibuprofen). The microbial community metabolic profiles in the saturated CW were shaped by plant presence and plant species, while no negative impact of iohexol and ibuprofen presence was noticed at the 100 μg L -1 . In addition, the microbial activity and richness were generally higher in planted mesocosms than in the unplanted systems in the summer. For the first time, a positive correlation between iohexol removal and the microbial community metabolic profiles (activity, richness and amines and amides utilization in summer, and carbohydrates utilization in winter) in the saturated mesocosms was observed.Putrescine utilization in the summer and D-cellobiose, D,L-alpha-glycerol phosphate in winter were linked with the metabolic processing of iohexol, while glycogen in summer and L-phenylalanine, Glycyl-L-glutamic acid in winter were linked with ibuprofen removal efficiency in the saturated CW.