Emerging delivery systems based on aqueous two-phase systems: A review

Controlling the diffusion of small molecules from matrices processed by all-aqueous methodologies: towards the development of green pharmaceutical products

“…Another important feature is the very low interfacial tension between the aqueous phases, which enhances their contact area and, therefore, the free diffusion and exchange of solutes. 133,134 The most common ATPS relies on the use of dextran (DEX) and PEG since these two polymers are biodegradable, biocompatible, and exhibit a stabilizing effect on most biological products. 133 Oppositely charged polyelectrolytes can be added to each aqueous phase, thus promoting single-step interfacial reactions and the formation of microparticles and capsules.…”

Metal ions: the unfading stars of bone regeneration—from bone metabolism regulation to biomaterial applications

“…To achieve intelligent release, future controlled-release strategies could include the spontaneous changes of materials to metabolic changes in the body. 283 (3) After metal ions are released, their therapeutic effects may decrease, and the design of a material with a metal ion recovery effect can improve the durability of the material and its response to secondary infection damage. 284…”

What Can Be Learned from the Partitioning Behavior of Proteins in Aqueous Two-Phase Systems?

“…These systems have found a wide range of applications in biotechnology [ 27 ], as the extraction, purification, isolation, cleanup, and recovery of various biological compounds, including proteins, can be achieved by ATPS-utilizing approaches based on liquid–liquid phase separation [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. The aqueous two-phase extraction utilized in protein separation is based on the fact that various proteins distribute differently between the two phases.…”