2014
DOI: 10.1038/nrclinonc.2014.192
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Abstract: Head and neck cancer (HNC) broadly includes carcinomas arising from the mucosal epithelia of the head and neck region as well as various cell types of salivary glands and the thyroid. As reflected by the multiple sites and histologies of HNC, the molecular characteristics and clinical outcomes of this disease vary widely. In this Review, we focus on established and emerging biomarkers that are most relevant to nasopharyngeal carcinoma and head and neck squamous-cell carcinoma (HNSCC), which includes primary si… Show more

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Cited by 247 publications
(235 citation statements)
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“…Silva et al [33] in their report of a cohort of laryngeal and oropharyngeal HNSCC did not show statistical difference between p16 expression and tumor localization (p16 + in 58.3% and 52.4% respectively). The carcinogenesis caused by tobacco and alcohol abuse and HPV infection is known to be synergistic to development of HNSCCs [34][35][36]. Our study could not find a statistical correlation between smoking tobacco and p16 status similar to findings by Lazarus et al [37] , and Ralli et al [27], but in contrast, Smith et al [32] showed significant association between alcohol and tobacco use (P < 0.05).…”
Section: Discussioncontrasting
confidence: 45%
“…Silva et al [33] in their report of a cohort of laryngeal and oropharyngeal HNSCC did not show statistical difference between p16 expression and tumor localization (p16 + in 58.3% and 52.4% respectively). The carcinogenesis caused by tobacco and alcohol abuse and HPV infection is known to be synergistic to development of HNSCCs [34][35][36]. Our study could not find a statistical correlation between smoking tobacco and p16 status similar to findings by Lazarus et al [37] , and Ralli et al [27], but in contrast, Smith et al [32] showed significant association between alcohol and tobacco use (P < 0.05).…”
Section: Discussioncontrasting
confidence: 45%
“…Few biomarkers related to tumor response to a therapy are already available for this tumor entity, for example: human papilloma virus infection [1][2], overexpression of epidermal growth factor receptor [5], tumor hypoxia or overexpression of cyclin D1 [6]. Apart from the inter-patient variations, an intra-tumor heterogeneity in treatment response is observed.…”
Section: Introductionmentioning
confidence: 99%
“…Analysis of genetic alterations and gene expression profiles holds potential for the stratification of HNSCC in the therapeutic context (28). In the present study, we used data retrieved from TCGA in order to explore the pathological and clinical significance of the tumour marker SCCA in HNSCC.…”
Section: Discussionmentioning
confidence: 99%