2011
DOI: 10.1111/j.1369-1600.2010.00296.x View full text |Buy / Rent full text
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Abstract: Reexposure to cocaine-associated environments promotes relapse to cocaine seeking and represents a persistent impediment to successful abstinence. Neurobiological adaptations are thought to underlie the preservation of drug-seeking behavior during protracted withdrawal periods, possibly including changes associated specifically with cocaine-paired contexts. We measured GluR1S845 and ERK phosphorylation in rat striatal subregions in an animal model of cocaine relapse. Animals with cocaine self-administration ex… Show more

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“…Extracellular signal-regulated kinase (ERK) is another intracellular signaling molecule involved in drug reinforcement that is influenced by exercise. Levels of ERK in the nucleus accumbens are correlated with drug self-administration and drug-seeking behavior across a number of different drugs, including stimulants (Lu et al, 2006; Koya et al, 2009; Lynch et al, 2010; Edwards et al, 2011), opioids (Li et al, 2008), and alcohol (Schroeder et al, 2008). Moreover, phosphorylated levels of ERK increase over an abstinence period, and these increases may serve to enhance responding in reinstatement procedures.…”
Section: Mechanisms Of Exercise On Drug Self-administration: Neurobiomentioning
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“…Extracellular signal-regulated kinase (ERK) is another intracellular signaling molecule involved in drug reinforcement that is influenced by exercise. Levels of ERK in the nucleus accumbens are correlated with drug self-administration and drug-seeking behavior across a number of different drugs, including stimulants (Lu et al, 2006; Koya et al, 2009; Lynch et al, 2010; Edwards et al, 2011), opioids (Li et al, 2008), and alcohol (Schroeder et al, 2008). Moreover, phosphorylated levels of ERK increase over an abstinence period, and these increases may serve to enhance responding in reinstatement procedures.…”
Section: Mechanisms Of Exercise On Drug Self-administration: Neurobiomentioning
“…Given that the pharmacological responsivity of the 5-HT 2C R is regulated by the localization of the receptor to cellular microdomains, such as membrane vs. cytoplasmic compartments (Herrick-Davis et al, 2015; Zacharias et al, 2002), we tested the hypothesis that incubation of cocaine cue reactivity (but not sucrose cue reactivity) is accompanied by a shift in the subcellular localization profile of the mPFC 5-HT 2C R protein. Self-administration of sucrose is a behaviorally consistent paradigm in which acquisition and lever press behavior for a natural reinforcer reasonably match those seen in cocaine self-administration (Choi et al, 2011; Edwards et al, 2011). Furthermore, incubation of sucrose cue reactivity is well-described (Grimm et al, 2006; Grimm et al, 2002), however 5-HT 2C R agonists do not suppress sucrose cue reactivity (Burbassi and Cervo, 2008; Cunningham et al, 2011).…”
Section: Introductionmentioning
“…Under the same experimental conditions, neither PFC, BLA or NAc were found to be involved (Fuchs et al, 2006, See et al, 2007). The role of dSTR in context-induced cocaine-seeking after abstience is further supported by findings of pronounced neuronal activation, as judged indirectly by phosphorylation of ERK1/2 mitogen-activated protein kinase (Edwards et al, 2011) and induction of immediate early genes (Zavala et al, 2007, Hearing et al, 2008) observed in this region immediately after relapse; or directly by functional imaging of dSTR during responding to cocaine-associated (contextual) cues (Volkow et al, 2006, Wong et al, 2006, Liu et al, 2013). …”
Section: Introductionmentioning