Emergence of community-acquired methicillin-resistant Staphylococcus aureus skin and soft tissue infections as a common cause of hospitalization in United States children

Frei, Christopher R.; Makos, Brittany; Daniels, Kelly R.; Oramasionwu, Christine U.

doi:10.1016/j.jpedsurg.2010.05.009

Cited by 74 publications

(63 citation statements)

References 13 publications

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“…5 Regional differences in prevalent clonal S aureus types have been well described in the United States, with highest rates of MRSA consistently reported in southern and Midwestern states in both early reports and more recent data. 3,41,42 In contrast, our study identified a recent convergence of rates of oxacillin susceptibility; by 2014 the southern United States, which in previous years had the highest percentage of MRSA, had only a 5% higher rate of oxacillin resistance than in the West, where oxacillin susceptibility remained high. This suggests that much of the overall increase in oxacillin susceptibility among S aureus was driven by decreasing resistance in these historically high MRSA regions.…”

Section: Discussioncontrasting

confidence: 58%

Changing Susceptibility of Staphylococcus aureus in a US Pediatric Population

et al. 2016

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Section: Discussioncontrasting

confidence: 58%

Changing Susceptibility of Staphylococcus aureus in a US Pediatric Population

et al. 2016

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“…However most of the studies report an alarming rise of MRSA in causing pyodermas. 23 No resistance was observed to vancomycin and linezolid in the study. Coagulase negative Staphylococcus was the next most common isolate with 12.75% in our study which is similar to many studies.…”

Section: Discussionmentioning

confidence: 73%

Clinico, bacteriological study of pyodermas at a tertiary care hospital, Andhra Pradesh: one year study

2017

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INTRODUCTIONPyodermas defined as purulent infection of the skin constitutes one of the common clinical conditions encountered by dermatologists in regular practice. Most of the studies in India state that pyodermas constitute 17% of cases in regular practice. Multiple factors like overcrowding, illiteracy, poor socio economic status, lack of hygienic practices account for personal factors in occurrence of pyodermas. Additional environmental ABSTRACT Background: Most of the studies in India state that pyodermas constitute 17% of cases in regular practice. Pyodermas are classified as primary and secondary. Primary pyodermas account for infection on normal skin whereas secondary on preexisting skin disease. The spectrum of pathogens, are however changing constantly as such their resistance to antibiotics. Indiscriminate usage of antibiotics, topical or systemic has lead to the development of resistance among the pathogens, which is a big problem to the physicians. The present study was conducted to assess the magnitude of different types of pyodermas, clinical types, the causative agents and their antibiotic susceptibility pattern. The study also determines the prevalence of MRSA among pyodermas. Methods: 375 newly diagnosed cases of pyodermas attending the OPD of department of Dermatology were enrolled in the study. A thorough clinical examination, demographic data, and relevant laboratory investigations were performed including culture and sensitivity. Results: The incidence of pyoderma in our study was 1.55% with male preponderance and common in 21-30 years age group. Primary pyodermas (225 cases) outnumbered secondary pyodermas (150 cases). Lower limbs were the most common site of pyodermas. Furuncle followed by folliculitis was most common primary pyodermas. Infectious eczematoid dermatitis was the most common entity in secondary pyodermas. Staphylococcus was the most common isolate in the study followed by Coagulase negative staphylococcus. Escherichia coli were most common gram negative isolate. Among diabetics, furuncle was commonest with history of 100% recurrence. Incidence of MRSA in the study was 47%. Gram negative isolates were susceptible to Carbapenems, fluroquinolones and higher generation cephalosporins. Conclusions: To conclude, our study highlighted the clinico epidemiological features of pyodermas attending our hospital. The common clinical types of primary and secondary pyodermas and associated risk factors were stated in the study. Etiological agents were identified in the study with antibiotic susceptibility, which especially assist the clinicians in selection of antibiotics in absence of culture and sensitivity.

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“…It is somewhat expected that the percentage of TMP-SMX used in children with SSTI demonstrated a significant increase around 2005 as multiple studies have confirmed an increase in MRSA infections approximating that time period. [11][12][13] With relatively few oral options for the empirical treatment of MRSA SSTI in the outpatient setting (clindamycin, TMP-SMX, tetracycline, and linezolid) 14 and the increasing rate of clindamycin resistance being reported in areas of the United States, 16 continued increases in the prescribing of TMP-SMX are likely. Such increased usage may be exacerbated by the limitations of alternative oral options (eg, contraindication of tetracyclines in children younger than 8 years of age or linezolid' s prohibitive cost).…”

Section: National Trends In Tmp-smx Prescriptionsmentioning

confidence: 99%

“…7 The majority of published data concerning TMP-SMX ADRs in children are associated with usage of TMP-SMX for urinary tract infections (UTIs), otitis media,gastroenteritis,or the prevention/ treatment of Pneumocystis jiroveci in children with HIV/AIDS. [7][8][9][10] With a wellrecognized increase of methicillinresistant Staphylococcus aureus (MRSA) associated skin and soft tissue infections (SSTIs) over the past decade and relatively few oral antimicrobial therapeutic options, [11][12][13][14] we hypothesized that the treatment of these SSTIs would be accompanied by an increase in TMP-SMX ADRs. Therefore, we sought to address 2 objectives.…”

mentioning

confidence: 99%

Trends in Adverse Reactions to Trimethoprim-Sulfamethoxazole

2012

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Emergence of community-acquired methicillin-resistant Staphylococcus aureus skin and soft tissue infections as a common cause of hospitalization in United States children

Cited by 74 publications

References 13 publications

Changing Susceptibility of Staphylococcus aureus in a US Pediatric Population

Changing Susceptibility of Staphylococcus aureus in a US Pediatric Population

Clinico, bacteriological study of pyodermas at a tertiary care hospital, Andhra Pradesh: one year study

Trends in Adverse Reactions to Trimethoprim-Sulfamethoxazole

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