2019
DOI: 10.1590/0037-8682-0352-2018
|View full text |Cite
|
Sign up to set email alerts
|

Emergence of bla NDM-1 associated with the aac(6’)-Ib-cr, acrB, cps, and mrkD genes in a clinical isolate of multi-drug resistant Klebsiella pneumoniae from Recife-PE, Brazil

Abstract: Introduction: The emergence of New Delhi metallo-β-lactamase (NDM) is concernig because it reduces the antibiotic therapy options for bacterial infections. Methods: Resistant and virulent genes from an isolate of Klebsiella pneumoniae derived from a patient with sepsis in a hospital in Recife-PE, Brazil, were investigated using PCR and DNA sequencing. Results: bla NDM-1 , aac(6')-Ib-cr and acrB resistance genes, and cps and mrkD virulence genes were detected. Conclusions: To our knowledge, this is the first re… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
4
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
6
1

Relationship

2
5

Authors

Journals

citations
Cited by 7 publications
(4 citation statements)
references
References 15 publications
0
4
0
Order By: Relevance
“…Da Silva et al (2019) 34 detected the bla NDM-1 gene in different species of Gram-negative bacteria isolated from nine Brazilian states but did not include the state of Pernambuco. Scavuzzi et al (2019) 35 detected an isolate of K. pneumoniae that in addition to harboring the bla NDM gene, also harbored bacterial virulence genes, and were the first to report strains carrying the bla NDM gene in bacterial isolates from Recife-PE. Additionally, Firmo et al (2019) 17 detected the occurrence of bla NDM in 25 % of K. pneumoniae isolates, and also in isolates from Recife-PE.…”
Section: Discussionmentioning
confidence: 99%
“…Da Silva et al (2019) 34 detected the bla NDM-1 gene in different species of Gram-negative bacteria isolated from nine Brazilian states but did not include the state of Pernambuco. Scavuzzi et al (2019) 35 detected an isolate of K. pneumoniae that in addition to harboring the bla NDM gene, also harbored bacterial virulence genes, and were the first to report strains carrying the bla NDM gene in bacterial isolates from Recife-PE. Additionally, Firmo et al (2019) 17 detected the occurrence of bla NDM in 25 % of K. pneumoniae isolates, and also in isolates from Recife-PE.…”
Section: Discussionmentioning
confidence: 99%
“…In Germany, E.coli transformants with NDM-7 have been reported to have higher MIC values for β-lactams when compared to transformants with NDM-1 [2]. While in Brazil, we have shown the association of different resistance and virulence mechanisms in isolates of K. pneumoniae with bla NDM−1 [3]. However, until now, the bla NDM−7 variant has not been detected in Brazil, although it is widespread in some regions of Asia.…”
Section: Introductionmentioning
confidence: 63%
“…Although several other carbapenemase-producing bacteria (KPC, GES, SPM, VIM) are reported to cause outbreaks or have endemic behavior in some Latin American institutions, the NDM enzyme has only been described in a few locations 2 . In Brazil, the enzyme has already been described in some states, such as Rio Grande do Sul, São Paulo, Paraná, Rio de Janeiro, Santa Catarina, Bahia, and Pernambuco 3 - 9 .…”
Section: Introductionmentioning
confidence: 99%