Emergence of a virulent porcine reproductive and respiratory syndrome virus in Taiwan in 2018

Lin, Wei‐Hao; Shih, Hsing‐Chun; Wang, Sheng‐Yuan; Lin, Chuen‐Fu; Yang, Cheng‐Yao; Chiou, Ming‐Tang; Lin, Chao‐Nan

doi:10.1111/tbed.13173

Cited by 8 publications

(6 citation statements)

References 12 publications

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“…Overall, the genetics of PRRSV in Asian countries have been dynamic. Independent evolution [12], transmission among Asian countries, introduction of novel PRRSV strains from outside Asia [13,14] and recombination between PRRSV strains [15] were all involved. Moreover, use of PRRS modified live virus (MLV) vaccines could also impact PRRSV genetic variation and the ongoing genetic changes of PRRSV [16] .…”

Section: Prrsvmentioning

confidence: 99%

Major swine viral diseases: an Asian perspective after the African swine fever introduction

2020

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Asia is a major pig producer of the world, and at present, African swine fever virus (ASFV) continues to significantly impact the Asian pig industry. Since more than 50% of the world's pig population is in Asia, ASFV outbreaks in Asia will affect the global pig industry. Prior to the introduction of ASF, several outbreaks of major swine viruses occurred in Asia over the last two decades, including porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV) and foot and mouth disease virus (FMDV). The rapid spreading of those viruses throughout Asia involve many factors such as the various pig production systems and supply chains ranging from backyard to intensive industrial farms, animal movement and animal product trading within and among countries, and consumer behaviors. ASF has notoriously been known as a human-driven disease. Travelers and international trading are the major ASFV-carriers for the transboundary transmission and introduction to naïve countries. Globalization puts the entire pig industry at risk for ASF and other infectious diseases arising from Asian countries. Disease control strategies for the various pig production systems in Asia are challenging. In order to ensure future food security in the region and to prevent the deleterious consequences of ASF and other major viral disease outbreaks, disease control strategies and production systems must be improved and modernized.

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Section: Prrsvmentioning

confidence: 99%

Major swine viral diseases: an Asian perspective after the African swine fever introduction

2020

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“…Previous reports show that prevalence rates of PRRSV-1 and PRRSV-2 were 29.4%, 38.4% (2007–2008), 51% and 54.4% (2013–2016), 37.4%, and 49% (2014–2019) [ 14 , 27 , 30 ]. It has been confirmed that both PRRSV-1 and PRRSV-2 coexist on swine farms in South Korea, which were similar to those in China, Hungary, and Taiwan [ 14 , 27 , 30 , 44 , 45 , 46 ].…”

Section: Discussionmentioning

confidence: 68%

Molecular Characterization of Porcine Reproductive and Respiratory Syndrome Virus in Korea from 2018 to 2022

et al. 2023

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Porcine reproductive and respiratory syndrome (PRRS) is an endemic disease in the Republic of Korea. Surveillance of PRRS virus (PRRSV) types is critical to tailor control measures. This study collected 5062 serum and tissue samples between 2018 and 2022. Open reading frame 5 (ORF5) sequences suggest that subgroup A (42%) was predominant, followed by lineage 1 (21%), lineage 5 (14%), lineage Korea C (LKC) (9%), lineage Korea B (LKB) (6%), and subtype 1C (5%). Highly virulent lineages 1 (NADC30/34/MN184) and 8 were also detected. These viruses typically mutate or recombine with other viruses. ORF5 and non-structural protein 2 (NSP2) deletion patterns were less variable in the PRRSV-1. Several strains belonging to PRRSV-2 showed differences in NSP2 deletion and ORF5 sequences. Similar vaccine-like isolates to the PRRSV-1 subtype 1C and PRRSV-2 lineage 5 were also found. The virus is evolving independently in the field and has eluded vaccine protection. The current vaccine that is used in Korea offers only modest or limited heterologous protection. Ongoing surveillance to identify the current virus strain in circulation is necessary to design a vaccine. A systemic immunization program with region-specific vaccinations and stringent biosecurity measures is required to reduce PRRSV infections in the Republic of Korea.

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“…The open reading frame 5 (ORF5) genes were amplified and sequenced as described in a previous study [26]. The nucleotide sequences were determined from both orientations by an ABI 3730XL DNA analyzer (Applied Biosystems, Foster City, CA).…”

Section: Open Reading Frame 5 Amplification and Sequencingmentioning

confidence: 99%

Outbreak of Porcine Reproductive and Respiratory Syndrome Virus 1 in Taiwan

Lin

Kaewprom

Wang

et al. 2020

Viruses

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Porcine reproductive and respiratory syndrome (PRRS) causes significant economic losses in the swine industry worldwide. The PRRS virus (PRRSV) can be divided into two species, PRRSV 1 (European) and PRRSV 2 (North American). In Taiwan, PRRSV 2 isolates are dominant and cause respiratory symptoms in nursing pigs. From October to November 2018, in a pig herd in central Taiwan, pregnant sows had abortions and stillbirths, and piglets suffered from respiratory disorders. Laboratory tests identified the presence of PRRSV 1 in serum from sows and suckling piglets in this scenario. The complete genome of the identified PRRSV 1 strain was genetically closely related to that of a European PRRSV vaccine strain (98.2%). This local European isolate is designated as PRRSV/NPUST-2789-3W-2/TW/2018 (NPUST2789). This report is the first to indicate an outbreak in Taiwan of a PRRSV 1 strain that shares a common evolutionary ancestor with the European PRRSV vaccine strain.

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Emergence of a virulent porcine reproductive and respiratory syndrome virus in Taiwan in 2018

Cited by 8 publications

References 12 publications

Major swine viral diseases: an Asian perspective after the African swine fever introduction

Major swine viral diseases: an Asian perspective after the African swine fever introduction

Molecular Characterization of Porcine Reproductive and Respiratory Syndrome Virus in Korea from 2018 to 2022

Outbreak of Porcine Reproductive and Respiratory Syndrome Virus 1 in Taiwan

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