2015
DOI: 10.1007/s11626-015-9951-6
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Abstract: Mouse tongue development is initiated with the formation of lateral lingual swellings just before fusion between the mediodorsal surfaces of the mandibular arches at around embryonic day 11.0. Here, we investigated the role of Sonic hedgehog (Shh) signaling in embryonic mouse tongue morphogenesis. For this, we used an organ culture model of the mandibular arches from mouse embryos at embryonic day 10.5. When the Shh signaling inhibitor jervine was added to the culture medium for 24-96 h, the formation of later… Show more

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Cited by 9 publications
(5 citation statements)
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“…Embryonically, Shh in central FGP placode cells is bracketed by Shh signaling cells that express Ptch1 and Gli1 (35). In embryonic tongue cultures, blockade of Shh signaling was achieved with the antagonists cyclopamine and jervine and a blocking antibody (37, 56, 57). The evidence supported Shh signaling as a principal, required regulator of tongue development as well as FGP formation, patterning, and differentiation, with concentration dependence in temporal and spatial contexts (58).…”
Section: Development and Tastementioning
confidence: 99%
“…Embryonically, Shh in central FGP placode cells is bracketed by Shh signaling cells that express Ptch1 and Gli1 (35). In embryonic tongue cultures, blockade of Shh signaling was achieved with the antagonists cyclopamine and jervine and a blocking antibody (37, 56, 57). The evidence supported Shh signaling as a principal, required regulator of tongue development as well as FGP formation, patterning, and differentiation, with concentration dependence in temporal and spatial contexts (58).…”
Section: Development and Tastementioning
confidence: 99%
“…NCCs directly underlie the dental placode, which expresses Sonic hedgehog ( Shh ), and condense around the placode in response to this epithelial signal (Hardcastle et al, 1998). A similar pattern of molecular or cellular response is observed in NCCs underlying epithelial Shh in the oral ectoderm overlaying the tongue anlage, the rugae of the developing palate, and the FEZ that defines the midface (Hu et al, 2003; Rice et al, 2006; Torii et al, 2016). Taken together, these data assert that during early craniofacial development, NCCs are highly responsive to cues emanating from signaling centers.…”
Section: Introductionmentioning
confidence: 68%
“…During the course of our phenotypic analysis of craniofacial defects associated with Eya1 deficiency, we noticed that the tongues of Eya1 −/− mice that die at birth ( Xu et al, 1999 ) were severely reduced in size compared to wild-type control littermates ( Figure 1A ). Although not directly related to the development of taste papillae, the tongue primordium forms from two lateral lingual swellings called the tongue buds, which originate from the floor of the first and second pharyngeal arches at E11.5 ( Paulson et al, 1985 ; Shuler and Dalrymple, 2001 ; Torii et al, 2016 ). In Eya1 −/− mice, the overall size of the tongue was noticeably smaller as early as E12.5 and drastically reduced in size by E18.5 compared to wild-type littermates ( Figure 1A ).…”
Section: Resultsmentioning
confidence: 99%