2011
DOI: 10.18632/aging.100333
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Although functional organ stem cells persist in the old, tissue damage invariably overwhelms tissue repair, ultimately causing the demise of an organism. The poor performance of stem cells in an aged organ, such as skeletal muscle, is caused by the changes in regulatory pathways such as Notch, MAPK and TGF-β, where old differentiated tissue actually inhibits its own regeneration. This perspective analyzes the current literature on regulation of organ stem cells by their young versus old niches and suggests tha… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

5
43
0

Year Published

2011
2011
2016
2016

Publication Types

Select...
7
1

Relationship

2
6

Authors

Journals

citations
Cited by 39 publications
(48 citation statements)
references
References 49 publications
5
43
0
Order By: Relevance
“…To address the molecular mechanism by which experimental diabetes causes the decline in muscle regeneration, we focused on TGF-β/pSmad signaling, since it has been previously found that excessive signaling through this pathway is capable of preventing the activation and proliferation of satellite cells [10,15,20] . To investigate if acute experimental dia- …”
Section: Experimental Diabetes Causes An Up-regulation Of Myostatin Amentioning
confidence: 99%
“…To address the molecular mechanism by which experimental diabetes causes the decline in muscle regeneration, we focused on TGF-β/pSmad signaling, since it has been previously found that excessive signaling through this pathway is capable of preventing the activation and proliferation of satellite cells [10,15,20] . To investigate if acute experimental dia- …”
Section: Experimental Diabetes Causes An Up-regulation Of Myostatin Amentioning
confidence: 99%
“…Furthermore, some evidence also exists for cross-talk between Notch and MAPK in developing and postnatal mammalian tissues [2, 10-12]. In muscle, once the blockage in the activation of aged satellite cells is overcome (for example by activation of Notch or by culture in mitogenic growth medium), their abilities to form myotubes are as robust as those of young cells both in vitro and in vivo [3, 6, 13, 14]. …”
Section: Introductionmentioning
confidence: 99%
“…Finally, the bone morphogenetic protein, BMP, signaling pathway has been shown to be a critical regulator of various embryonic and adult stem cell niches [14,15]. BMP is a ligand for the TGF-β protein superfamily and its signal transduction operates through the Smad1, 5 and 8 transcription factors, which become phosphorylated and activated by BMP receptors and form heterodimers with constitutively present Smad4.…”
Section: Introductionmentioning
confidence: 99%
“…This includes achieving compressor stability and control near the critical point [4], devising high pressure approaches to bearings and seals [5], and developing control procedures from cold-startup to break-even conditions for a simple recuperated Brayton cycle [6]. Likewise, operation of a simple recuperated cycle during steady-state power production at 20 kWĥ as been reported in detail [7]. Still, it is only recently that the test facility has neared its final design configuration, utilizing dual compressors, allowing the loop to begin to approach rated conditions.…”
Section: Introductionmentioning
confidence: 99%