Embelin ameliorates dextran sodium sulfate-induced colitis in mice

Orally administered aqueous extract of Inonotus obliquus ameliorates acute inflammation in dextran sulfate sodium (DSS)-induced colitis in mice

“…Our results (Figs. 4 and 6A) are consistent with previous findings that inhibition of TNF-a release consecutively inhibits the increased level of iNOS and subsequent colonic damage and inflammation in a murine colitis model (Cho et al, 2010;Colon et al, 2001;Má rquez et al, 2010;Kumar et al, 2011;Bassaganya-Riera et al, 2011). IL-1b and IL-6 are other key mediators of the progression of IBD.…”

“…Consequently, alternative therapeutic strategies, including plant-based traditional remedies are now being re-evaluated. Several studies have shown effectiveness of natural products, herbs, and dietary components against inflammatory colitis such as Patrinia (Cho et al, 2010), Mangifera (Má rquez et al, 2010), sterol guggulsterone (Cheon et al, 2006), apple procyanidins (Yoshioka et al, 2008), embelin (Kumar et al, 2011), punicic acid (Bassaganya-Riera et al, 2011, and a combination of dietary fish oil and curcumin (Jia et al, 2011). Chaga mushroom has also been effectively used in several medicinal preparations to treat a variety of inflammatory and digestive system diseases, without any toxicity and side effects Nakajima et al, 2007;Shashkina et al, 2006;Wasser and Weis, 1999).…”

Embelin Reduces Colitis-Associated Tumorigenesis through Limiting IL-6/STAT3 Signaling

“…Recently, embelin was found to inhibit constitutive STAT3 activation in human cancer cell lines (13). Other studies have shown that embelin could ameliorate pro-inflammatory agent-induced acute colitis in mice (14,15). These studies suggested that embelin may have potential therapeutic benefit for human IBD.…”

Embelia ribes ameliorates lipopolysaccharide-induced acute respiratory distress syndrome

“…Recently, it is reported to possess a wide range of pharmacological properties such as antitumor, anti-inflammatory, analgesic (Chitra et al, 1994), antihyperlipidemic, antihyperglycemic (Mahendran et al, 2011a), antifertility (Sharma et al, 2001), anticonvulsant (Mahendran et al, 2011b), cardioprotective (Bhandari et al, 2008), antioxidant (Joshi et al, 2007) and wound healing properties (Kumara Swamy et al, 2007). Embelin showed protective effect against ulcerative colitis induced by acetic acid in rats (Thippeswamy et al, 2011) and dextran sodium sulfate in mice (Kumar et al, 2011). However, embelin, a benzoquinone has not been investigated so far for its effectiveness in treatment of ARDS, though the plant is traditionally used against such disorders (Kirthikar and Basu, 1987).…”