Abstract:Reliable DNA replication is completed by the orchestrated activation of a multi-protein machinery, the replisome, in a highly coordinated and dynamic fashion. The bacteriophage T7 gene 2.5 protein (gp2.5) works as a single strand DNA(ssDNA) binding protein and has been demonstrated to play a key role in the maintenance of ssDNA stability as well as the suppression of hairpin formation during each cycle of Okazaki fragment synthesis. After gp2.5 binding to ssDNA, gp2.5 might act as a road block for DNA polymera… Show more
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