Elucidation of the mechanism underlying impaired sensorimotor gating in patients with primary blepharospasm using prepulse inhibition

Hao, Xinqing; Huang, Xiaofeng; Yin, Xin; Wang, Haiyang; Liu, Ren; Liang, Zhanhua; Song, Chen

doi:10.3389/fneur.2023.1105483

Cited by 2 publications

(2 citation statements)

References 52 publications

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“…Diffusion tensor tractography also showed abnormal nodal efficiency in S1 (31). Sensory impairment is also an important feature of clinical heterogeneity in BSP, and patients commonly experience pain, a sense of discomfort, an impaired sensory discrimination threshold, and sensory gating (2,32). As sensory impairment frequently precedes clinical symptoms but involves a wider area than the site of dystonia, it has been considered to be an inherent component of blepharospasm pathophysiology (33).…”

Section: Discussionmentioning

confidence: 99%

Functional connectivity alterations in the frontoparietal network and sensorimotor network are associated with behavioral heterogeneity in blepharospasm

Huang,

Hao,

Yin

et al. 2023

Front. Neurol.

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ObjectivePrimary blepharospasm (BSP) is a clinically heterogeneous disease that manifests not only as spasmodic closure of the eyelids but also sometimes with apraxia of eyelid opening (AEO). This cross-sectional study aimed to investigate differences in the neural mechanisms of isolated BSP and BSP-associated AEO subtypes, which may reveal the pathophysiology underlying different phenotypes.MethodsA total of 29 patients manifested as isolated BSP, 17 patients manifested as BSP associated with AEO, and 28 healthy controls underwent resting-state functional near-infrared spectroscopy (fNIRS). We assessed functional connectivity (FC) between regions of interest (ROIs) in the fronto-parietal control network (PFCN) and sensorimotor network (SMN). We also examined the relationship between altered FC and behavioral data.ResultsIn the FPCN, ROI- analyses showed decreased FC between the left premotor cortex and supramarginal gyrus in the BSP with AEO group compared to the isolated BSP group. In the SMN, both subgroups showed hypoconnectivity of the left premotor cortex with the right primary motor cortex, primary sensory cortex, and somatosensory association cortex. This hypoconnectivity was positively correlated with the total number of botulinum toxin A treatments, which suggests that long-term botulinum toxin A treatment may modulate motor sequence planning and coordination.ConclusionThese findings showed different connectivity alterations in neural networks associated with motor and cognitive control among different behavioral phenotypes of BSP. The identification of specific alterations in various networks that correspond to clinical heterogeneity may inform the identification of potential biomarkers for early diagnosis and personalized neuromodulation targets for treating different BSP subphenotypes.

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Section: Discussionmentioning

confidence: 99%

Functional connectivity alterations in the frontoparietal network and sensorimotor network are associated with behavioral heterogeneity in blepharospasm

Huang,

Hao,

Yin

et al. 2023

Front. Neurol.

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“…The presence of an abnormal blink reflex recovery cycle in patients with blepharospasm confirms the hyperexcitability of the trigeminal facial circuit. A study on 30 patients with blepharospasm, and 20 sex- and age-matched healthy controls, found impaired prepulse inhibition of the blink reflex in patients with blepharospasm, suggesting that abnormal regulation of cortical and subcortical inhibition may also lead to hyperexcitability of the trigeminal facial circuit ( 54 ).…”

Section: Anatomy and Physiologymentioning

confidence: 99%

The pathogenesis of blepharospasm

Zhu,

Meng,

Zhang

et al. 2024

Front. Neurol.

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Blepharospasm is a focal dystonia characterized by involuntary tetanic contractions of the orbicularis oculi muscle, which can lead to functional blindness and loss of independent living ability in severe cases. It usually occurs in adults, with a higher incidence rate in women than in men. The etiology and pathogenesis of this disease have not been elucidated to date, but it is traditionally believed to be related to the basal ganglia. Studies have also shown that this is related to the decreased activity of inhibitory neurons in the cerebral cortex caused by environmental factors and genetic predisposition. Increasingly, studies have focused on the imbalance in the regulation of neurotransmitters, including dopamine, serotonin, and acetylcholine, in blepharospasm. The onset of the disease is insidious, and the misdiagnosis rate is high based on history and clinical manifestations. This article reviews the etiology, epidemiological features, and pathogenesis of blepharospasm, to improve understanding of the disease by neurologists and ophthalmologists.

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Elucidation of the mechanism underlying impaired sensorimotor gating in patients with primary blepharospasm using prepulse inhibition

Cited by 2 publications

References 52 publications

Functional connectivity alterations in the frontoparietal network and sensorimotor network are associated with behavioral heterogeneity in blepharospasm

Functional connectivity alterations in the frontoparietal network and sensorimotor network are associated with behavioral heterogeneity in blepharospasm

The pathogenesis of blepharospasm

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