Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway

Ou, Hsiu Chung; Lee, Wen Jane; Lee, Shin-Da; Huang, Chih Yang; Chiu, Te-Fa; Tsai, Kun Ling; Hsu, Wen Cheng; Sheu, Wayne Huey Herng

doi:10.1016/j.taap.2010.07.025

Cited by 97 publications

(60 citation statements)

References 48 publications

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“…Increased as well as decreased expressions of HSPs [43,44] as well as of Bcl2 have been described [45,46,47]. Upregulation by polyphenols of the growth arrest and DNA damage inducible (GADD45) proteins [48,49] has been reported elsewhere.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Intake of Resveratrol, Resveratrol Phosphate, and Catechin-Rich Grape Seed Extract on Markers of Oxidative Stress and Gene Expression in Adult Obese Subjects

Groote¹,

Belleghem²,

Devière³

et al. 2012

Ann Nutr Metab

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Background: The preventive effect of resveratrol (RES) on the development of human diseases has been verified by numerous epidemiological studies. Resveratrol triphosphate (RTP) is a stable derivative of RES in which phosphate groups protect the phenolic groups. Aims: This study compared the effect of RTP on biochemical and molecular markers of oxidative stress to equimolar doses (0.66 mmol) of RES and catechin-rich grape seed extract (CGSE) in a model of oxidative and metabolic stress associated with obesity in humans. Methods: Thirty-two obese subjects (BMI between 30 and 40) were enrolled. They all received 1 capsule of placebo/day for 28 days before being randomly devised into three arms receiving 1 capsule/day of RES, CGSE, or RTP during the following consecutive 28 days. Blood samples were collected at baseline, after the end of placebo intake, and after the end of the investigational product intake. Biochemical parameters of oxidative stress and blood expression of 200 redox-related genes were determined at each time point. Results: RTP and CGSE showed better antioxidant activities compared to RES and induced important modulations of gene expression. Conclusion: The results suggest that RTP and CGSE could contribute to a significant reduction of oxidative stress in obese subjects.

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Section: Discussionmentioning

confidence: 99%

Effect of the Intake of Resveratrol, Resveratrol Phosphate, and Catechin-Rich Grape Seed Extract on Markers of Oxidative Stress and Gene Expression in Adult Obese Subjects

Groote¹,

Belleghem²,

Devière³

et al. 2012

Ann Nutr Metab

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show abstract

“…PI3K/AKT and ERK1/2 pathways also play key roles in GLP-1R action. For example, ABCA1 expression is regulated by the PI3K/AKT pathway (32,59). In addition, the GLP-1R agonist liraglutide suppresses damage in microvascular endothelial cells through the PI3K/ AKT pathway (33).…”

Section: Exendin-4 Improves Abca1-mediated Cholesterol Effluxmentioning

confidence: 99%

Exendin-4 Ameliorates Lipotoxicity-induced Glomerular Endothelial Cell Injury by Improving ABC Transporter A1-mediated Cholesterol Efflux in Diabetic apoE Knockout Mice

Yin

Zhang

et al. 2016

Journal of Biological Chemistry

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“…In recent years ellagic acid has been the subject of intense research within the fields of cancer and inflammation, however, its protective effect against oxidized LDL-induced injury in vascular endothelial cells have not been clarified. Ou et al (2010) investigated the antiapoptotic effect of ellagic acid in human umbilical vein endothelial cells (HUVECs) exposed to OxLDL and explored the possible mechanisms. Pretreatment with ellagic acid (5-20 μM) significantly attenuated OxLDL-induced cytotoxicity, apoptotic features, and generation of ROS.…”

Section: Cardiovascular Healthmentioning

confidence: 99%

The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer

Akpinar‐Bayizit¹,

Özcan²,

Yilmaz‐Ersan³

2012

Cancer Prevention - From Mechanisms to Translational Benefits

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Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway

Cited by 97 publications

References 48 publications

Effect of the Intake of Resveratrol, Resveratrol Phosphate, and Catechin-Rich Grape Seed Extract on Markers of Oxidative Stress and Gene Expression in Adult Obese Subjects

Effect of the Intake of Resveratrol, Resveratrol Phosphate, and Catechin-Rich Grape Seed Extract on Markers of Oxidative Stress and Gene Expression in Adult Obese Subjects

Exendin-4 Ameliorates Lipotoxicity-induced Glomerular Endothelial Cell Injury by Improving ABC Transporter A1-mediated Cholesterol Efflux in Diabetic apoE Knockout Mice

The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer

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