ELK1-induced upregulation of lncRNA HOXA10-AS promotes lung adenocarcinoma progression by increasing Wnt/β-catenin signaling

Sheng, Kai; Lu, Jiahuan; Zhao, Hui

doi:10.1016/j.bbrc.2018.04.224

Cited by 44 publications

(32 citation statements)

References 33 publications

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“…27 In this study, we focused on a new transcription factor, ELK1 which had been reported to act as a regulatory factor in the transcription of lncRNA MIR100HG and lncRNA HOXA10-AS in osteosarcoma and lung adenocarcinoma, respectively. 28,29 Using JASPAR tools, we found that ELK1 may be an upstream transcription factor of TRPM2-AS. Subsequent assays revealed the affinity of ELK1 to TRPM2-AS promoter using luciferase activity and ChIP assay.…”

Section: Discussionmentioning

confidence: 99%

ELK1‐induced upregulation of lncRNA TRPM2‐AS promotes tumor progression in gastric cancer by regulating miR‐195/ HMGA1 axis

Huang¹,

Chang²,

Wang³

et al. 2019

J of Cellular Biochemistry

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Long noncoding RNAs (lncRNAs) have been confirmed to be aberrantly expressed in various diseases including tumors. Recently, a new tumor‐related lncRNA, lncRNA TRPM2 antisense RNA (TRPM2‐AS), was shown to be involved in many tumors, such as lung cancer and breast cancer. However, the expression and role of TRPM2‐AS in the development of gastric cancer (GC) have not been elucidated. In the current study, we provided evidence that the expression levels of TRPM2‐AS were increased in both GC tissues and cell lines. We also showed that overexpression of TRPM2‐AS was modulated by ELK1, a transcription factor. The results of clinical assays showed that higher expressions of TRPM2‐AS were significantly related with invasion depth, TNM stage, lymphatic metastasis, and shorter overall survival. Further clinical assays using multivariate analysis suggested that TRPM2‐AS expression was an independent prognostic factor in patients with GC. Functional experiments illustrated that depression of TRPM2‐AS suppressed proliferation, migration, and invasion in GC cells. In terms of mechanism, we found that TRPM2‐AS directly inhibited miR‐195, which targeted the 3′‐untranslated region of high‐mobility group AT‐hook 1 (HMGA1) messenger RNA. Overall, these findings revealed that ELK1‐induced overexpression of TRPM2‐AS promoted the development and progression of GC in part through miR‐195/HMGA1 signaling axis, and established its candidacy as a new cancer biomarker for GC patients.

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Section: Discussionmentioning

confidence: 99%

ELK1‐induced upregulation of lncRNA TRPM2‐AS promotes tumor progression in gastric cancer by regulating miR‐195/ HMGA1 axis

Huang¹,

Chang²,

Wang³

et al. 2019

J of Cellular Biochemistry

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“…One of the target genes of miR-139-3p is ELK1. ELK1, a transcription factor in the ETS family, acts as an essential component of the mitogen regulation pathway that activates the mitogen-activated protein kinase cascade 38 . It has been proven that ELK1 regulates various cell processes and is closely related to osteogenic differentiation [39][40][41] .…”

Section: Discussionmentioning

confidence: 99%

Targeted overexpression of the long noncoding RNA ODSM can regulate osteoblast function in vitro and in vivo

Wang

Zhang

et al. 2020

Cell Death Dis

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Ameliorating bone loss caused by mechanical unloading is a substantial clinical challenge, and the role of noncoding RNAs in this process has attracted increasing attention. In this study, we found that the long noncoding RNA osteoblast differentiation-related lncRNA under simulated microgravity (lncRNA ODSM) could inhibit osteoblast apoptosis and promote osteoblast mineralization in vitro. The increased expression level of the lncRNA ODSM partially reduced apoptosis and promoted differentiation in MC3T3-E1 cells under microgravity unloading conditions, and the effect was partially dependent on miR-139-3p. LncRNA ODSM supplementation in hindlimb-unloaded mice caused a decrease in the number of apoptotic cells in bone tissue and an increase in osteoblast activity. Furthermore, targeted overexpression of the lncRNA ODSM in osteoblasts partially reversed bone loss induced by mechanical unloading at the microstructural and biomechanical levels. These findings are the first to suggest the potential value of the lncRNA ODSM in osteoporosis therapy and the treatment of pathological osteopenia.

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“…Among them, 17 associations including two pairs of TF regulation and 17 pairs of RBP interaction were found to be co‐expressed. One of 2 TFs, ELK1 , is an important regulator and known to activate many lncRNAs including TRPM2‐AS , MIR100HG , and HOXA10‐AS in cancer until now, indicating ELK1 may induce expression of LINC01234 to promote tumor progression in GC too.…”

Section: Discussionmentioning

confidence: 99%

Function and regulation annotation of up‐regulated long non‐coding RNA LINC01234 in gastric cancer

Zhu

Luo

Korakkandan

et al. 2020

Clinical Laboratory Analysis

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Background Accumulated evidences indicate that long non‐coding RNAs (lncRNAs) participate in many biological mechanisms. Moreover, it acts as an essential regulator in various human diseases such as gastric cancer (GC). Nevertheless, the comprehensive regulatory roles and clinical significance of most lncRNAs in GC are not fully understood. Methods In this research, our aim was to investigate the underlying mechanism of lncRNA LINC01234 in GC. Firstly, the usage of qRT‐PCR helped to establish expression pattern of LINC01234 in GC tissues. Following this, appropriate statistical tests were applied to analyze the relation between expression level and clinicopathological factors. Ultimately, potential functions and regulatory network of LINC01234 were concluded via GSEA and a series of bioinformatics tools or databases, respectively. Results Consequently, at the end of research we found LINC01234 is up‐regulated in GC tissues in comparison with adjacent normal tissues. Furthermore, its expression level is correlated with differentiation of patients with GC. It is also important to highlight bioinformatics analysis revealed that LINC01234 is involved in cancer‐associated pathways such as cell cycle and mismatch repair. Also, regulatory network of LINC01234 presented a probability in the involvement of tumorigenesis through regulating cancer‐associated genes. Conclusion Overall, our results suggested that LINC01234 may play a crucial role in GC.

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ELK1-induced upregulation of lncRNA HOXA10-AS promotes lung adenocarcinoma progression by increasing Wnt/β-catenin signaling

Cited by 44 publications

References 33 publications

ELK1‐induced upregulation of lncRNA TRPM2‐AS promotes tumor progression in gastric cancer by regulating miR‐195/ HMGA1 axis

ELK1‐induced upregulation of lncRNA TRPM2‐AS promotes tumor progression in gastric cancer by regulating miR‐195/ HMGA1 axis

Targeted overexpression of the long noncoding RNA ODSM can regulate osteoblast function in vitro and in vivo

Function and regulation annotation of up‐regulated long non‐coding RNA LINC01234 in gastric cancer

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