Elevation of a novel pituitary protein (7B2) in the plasma in small cell carcinoma of the lung

Neuroendocrine secretory protein 7B2: structure, expression and functions

“…A correlation between plasma 7B2 and plasma gonadotropins was also reported in menopause and patients suffering from Klinefelter's syndrome, as well as in patients with various human chorionic gonadotropin-secreting tumours of the gastrointestinal tract [134]. In the same vein, 7B2 was shown to be actively secreted by functionless pituitary [133] adenoma, which are often associated with gonadotropin production [139]. High levels of circulating 7B2 have been detected in patients with other specific tumours of neuroendocrine origin.…”

“…Its mean plasma level in healthy adults ranges from 40-140 pmol\litre [9,[125][126][127][128][129][130][131][132][133][134][135][136]. It is remarkably high (as high as 1 nmol\litre) in early childhood, gradually decreases to adult levels by 20 years of age and slowly rises with aging [126,128].…”

Neuroendocrine secretory protein 7B2: structure, expression and functions

“…A correlation between plasma 7B2 and plasma gonadotropins was also reported in menopause and patients suffering from Klinefelter's syndrome, as well as in patients with various human chorionic gonadotropin-secreting tumours of the gastrointestinal tract [134]. In the same vein, 7B2 was shown to be actively secreted by functionless pituitary [133] adenoma, which are often associated with gonadotropin production [139]. High levels of circulating 7B2 have been detected in patients with other specific tumours of neuroendocrine origin.…”

“…Its mean plasma level in healthy adults ranges from 40-140 pmol\litre [9,[125][126][127][128][129][130][131][132][133][134][135][136]. It is remarkably high (as high as 1 nmol\litre) in early childhood, gradually decreases to adult levels by 20 years of age and slowly rises with aging [126,128].…”

Neuroendocrine secretory protein 7B2: structure, expression and functions

“…7B2 is detectable in human plasma. Its mean plasma level in healthy adults ranges from 40-140 pmol\litre [9,[125][126][127][128][129][130][131][132][133][134][135][136]. It is remarkably high (as high as 1 nmol\litre) in early childhood, gradually decreases to adult levels by 20 years of age and slowly rises with aging [126,128].…”

Neuroendocrine secretory protein 7B2: structure, expression and functions

“…A correlation between plasma 7B2 and plasma gonadotropins was also reported in menopause and patients suffering from Klinefelter's syndrome, as well as in patients with various human chorionic gonadotropin-secreting tumours of the gastrointestinal tract [134]. In the same vein, 7B2 was shown to be actively secreted by functionless pituitary [133] adenoma, which are often associated with gonadotropin production [139]. High levels of circulating 7B2 have been detected in patients with other specific tumours of neuroendocrine origin.…”

“…Its mean plasma level in healthy adults ranges from 40-140 pmol\litre [9,[125][126][127][128][129][130][131][132][133][134][135][136]. It is remarkably high (as high as 1 nmol\litre) in early childhood, gradually decreases to adult levels by 20 years of age and slowly rises with aging [126,128].…”

Neuroendocrine secretory protein 7B2: structure, expression and functions

“…7B2 is detectable in human plasma. Its mean plasma level in healthy adults ranges from 40-140 pmol\litre [9,[125][126][127][128][129][130][131][132][133][134][135][136]. It is remarkably high (as high as 1 nmol\litre) in early childhood, gradually decreases to adult levels by 20 years of age and slowly rises with aging [126,128].…”

Neuroendocrine secretory protein 7B2: structure, expression and functions

“…A correlation between plasma 7B2 and plasma gonadotropins was also reported in menopause and patients suffering from Klinefelter's syndrome, as well as in patients with various human chorionic gonadotropin-secreting tumours of the gastrointestinal tract [134]. In the same vein, 7B2 was shown to be actively secreted by functionless pituitary [133] adenoma, which are often associated with gonadotropin production [139]. High levels of circulating 7B2 have been detected in patients with other specific tumours of neuroendocrine origin.…”

“…Its mean plasma level in healthy adults ranges from 40-140 pmol\litre [9,[125][126][127][128][129][130][131][132][133][134][135][136]. It is remarkably high (as high as 1 nmol\litre) in early childhood, gradually decreases to adult levels by 20 years of age and slowly rises with aging [126,128].…”

Neuroendocrine secretory protein 7B2: structure, expression and functions

“…7B2 is detectable in human plasma. Its mean plasma level in healthy adults ranges from 40-140 pmol\litre [9,[125][126][127][128][129][130][131][132][133][134][135][136]. It is remarkably high (as high as 1 nmol\litre) in early childhood, gradually decreases to adult levels by 20 years of age and slowly rises with aging [126,128].…”