Elevated ZC3H15 increases HCC growth and predicts poor survival after surgical resection

Jiang, Bei‐Ge; Wan, Zhenghua; Huang, Jian; Li, Limei; Liu, Hui; Fu, Shimin; Yang, Yuan; Zhang, Jin; Yuan, Shen-xian; Wang, Ruoyu; Yang, Yun; Gu, Fangming; Dong, Liwei; Pan, Ze‐Ya; Zhou, Weiping

doi:10.18632/oncotarget.9361

Cited by 9 publications

(21 citation statements)

References 32 publications

(30 reference statements)

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“…The biological mechanism of ZC3H15 in human cancers remains largely unclear. Bei et al used a microarray to evaluate the functional role of ZC3H15, and they found that ZC3H15 was involved in several critical signaling pathways, such as WNT pathway, NF-κB pathway, EGF pathway, TGF-β pathway, and PDGF pathway [18]. Here, we demonstrated that silencing of ZC3H15 reduced the protein expression levels of c-Myc and its downstream molecules such as CDK4, CDK6, and CyclinD1 in GC cells.…”

Section: Discussionmentioning

confidence: 53%

“…Moreover, Gianni et al has revealed the interaction of ZC3H15 with TRAF2, which was responsible for the activation of NF-κB signaling [13][14][15][16][17]. Indeed, ZC3H15 act as an important role involved in cell proliferation, apoptosis, cell adhesion, and transcription, and dysregulation of ZC3H15 has been reported in hepatocellular carcinoma (HCC) and acute myeloid leukemia (AML) [18]. However, the biological role of ZC3H15 expression in GC is unclear.…”

Section: Introductionmentioning

confidence: 99%

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MiR-124-3p/ZC3H15 Regulates Gastric Cancer Progression by Blocking FBXW7 Mediated Degradation of c-Myc

Hou¹,

Liu²,

Du³

et al. 2020

Preprint

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BACKGROUND: Zinc finger CCCH-type containing 15 (ZC3H15), a highly conserved eukaryotic protein, was involved in tumorigenesis and may be a potential biomarker in hepatocellular carcinoma (HCC) and acute myeloid leukemia (AML). However, the biological role of ZC3H15 in gastric cancer (GC) is unclear.METHODS: The potential correlation between ZC3H15 expression and GC prognosis was assessed based on the patient data analysis. The biological role of ZC3H15 in regulating cell proliferation and metastasis was evaluated in vitro and in vivo. In addition, the potential mechanism of ZC3H15 was investigated. RESULTS: we found that ZC3H15 expression was positively correlated with GC progression, including cell growth, metastasis and cancerogenesis. Through further investigations, we found that ZC3H15 could modulate c-Myc protein stability via suppressing the transcription of FBXW7, which was mainly responsible for c-Myc degradation. In addition, we revealed that miR-124-3p, a tumor suppressor of GC, was negatively associated with ZC3H15. We revealed that miR-124-3p was a critical upstream modulator of ZC3H15 in GC.CONCLUSIONS: Taken together, our studies unearth the important roles of ZC3H15 in GC development and suggest that miR-124-3p/ZC3H15/c-Myc axis may be a potential target for the treatment of GC.

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Section: Discussionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%

MiR-124-3p/ZC3H15 Regulates Gastric Cancer Progression by Blocking FBXW7 Mediated Degradation of c-Myc

Hou¹,

Liu²,

Du³

et al. 2020

Preprint

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“…The DRG GTPases have been implicated in a variety of cellular processes including cell growth and proliferation. Several papers have suggested that DRG1, DRG2 and DFRP1 are required for the growth and proliferation of various cancer cell lines [56,[84][85][86][87][88]. Together, these reports suggest that DRG GTPases promote the growth and viability of proliferating cells.…”

Section: Cell Proliferation and Cancermentioning

confidence: 94%

“…DFRP1 is overexpressed in hepatocellular carcinomas where high expression is correlated with decreased survival [ 86 ]. In a hepatocellular cell line knockdown of DFRP1 results in reduced cell proliferation in addition to causing an increase in apoptosis [ 86 ]. Depleting DFRP1 also reduced the growth of tumors in mice [ 86 ].…”

Section: Roles Of Drgs and Dfrps In Diseasementioning

confidence: 99%

Developmentally regulated GTPases: structure, function and roles in disease

Westrip

Zhuang

Hall

et al. 2021

Cell. Mol. Life Sci.

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GTPases are a large superfamily of evolutionarily conserved proteins involved in a variety of fundamental cellular processes. The developmentally regulated GTP-binding protein (DRG) subfamily of GTPases consists of two highly conserved paralogs, DRG1 and DRG2, both of which have been implicated in the regulation of cell proliferation, translation and microtubules. Furthermore, DRG1 and 2 proteins both have a conserved binding partner, DRG family regulatory protein 1 and 2 (DFRP1 and DFRP2), respectively, that prevents them from being degraded. Similar to DRGs, the DFRP proteins have also been studied in the context of cell growth control and translation. Despite these proteins having been implicated in several fundamental cellular processes they remain relatively poorly characterized, however. In this review, we provide an overview of the structural biology and biochemistry of DRG GTPases and discuss current understanding of DRGs and DFRPs in normal physiology, as well as their emerging roles in diseases such as cancer.

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“…Among all patients, tumor size ranged from 1.5 to 13.8 cm (median size, 6.0 cm). Tumor differentiation was classified as high differentiation, moderate differentiation or low differentiation ( 14 ). According to the Barcelona Clinical Liver Cancer system (BCLC), HCC was classified as early stage (BCLC A), intermediate stage (BCLC B), or advanced stage (BCLC C) ( 4 ).…”

Section: Methodsmentioning

confidence: 99%

Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma

Deng

et al. 2018

Oncol Lett

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The objective of the present study was to investigate the association between zinc finger protein (ZNF) 689 expression and the clinicopathological features and prognosis of hepatocellular carcinoma (HCC). A total of 102 paired HCC and paired non-cancerous tissues, and 16 normal liver tissues were collected. ZNF689 expression was examined in HCC tissues, paired-noncancerous tissues, and normal liver tissues using RT-qPCR and immunohistochemistry analysis, and the association between ZNF689 expression and HCC prognosis was analyzed using the Kaplan-Meier method. ZNF689 expression was not significantly different between HCC tissues and paired-noncancerous tissues (P=0.61). ZNF689 expression in HCC and paired-noncancerous tissues was significantly increased compared with that in normal liver tissues (P<0.01). Positive expression of ZNF689 protein in HCC was significantly associated with a tumor size of ≥10 cm, tumor capsule infiltration, and microvascular invasion (P<0.05). Positive expression of ZNF689 was a prognostic factor for overall survival time [hazard ratio (HR):1.961; P=0.048] and progression-free survival time (HR:1.902; P=0.041). ZNF689 maybe a novel predictor for prognosis of patients with HCC.

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Elevated ZC3H15 increases HCC growth and predicts poor survival after surgical resection

Cited by 9 publications

References 32 publications

MiR-124-3p/ZC3H15 Regulates Gastric Cancer Progression by Blocking FBXW7 Mediated Degradation of c-Myc

MiR-124-3p/ZC3H15 Regulates Gastric Cancer Progression by Blocking FBXW7 Mediated Degradation of c-Myc

Developmentally regulated GTPases: structure, function and roles in disease

Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma

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