Elevated serum total IgE is associated with eczema exacerbation in children hospitalized for atopic dermatitis

Abstract

Background/Objectives: Atopic dermatitis (AD) can be a debilitating skin condition, often leading to hospitalization due to severe AD exacerbations or infectious complications. As both AD exacerbations and infectious complications can present similarly, it can be difficult to distinguish the two conditions. Thus, we aimed to evaluate if there is any difference in serum IgE levels in children with AD who were hospitalized for AD exacerbation and for AD-associated infectious complications.Methods: A retrospective chart review was performed on hospitalized children with AD exacerbations and AD-associated infectious complications over a 17-year span.Data including length of stay, primary diagnosis, systemic antibiotics, laboratory, and bacterial culture results were collected. Serum total immunoglobulin E (IgE) levels were adjusted by age. Age, length of stay, total IgE levels, and age-adjusted IgE levels were compared using t-test. Logistic regression was used for age-adjusted IgE levels. Results:The mean serum total IgE level in subjects with AD exacerbation was 9603 ± 15,873 kU/L, which was significantly higher than that of subjects with infectious complications at 3167 ± 5486 kU/L (p = .029). Logistic regression revealed that subjects with an age-adjusted IgE of >4 had more than 3-fold odds of having AD exacerbation than infectious complications.Conclusions: Our results suggest that total IgE levels are higher in children who were hospitalized for AD exacerbation than those with AD-associated infectious complications.

Đặc Điểm Lâm Sàng Và Một Số Yếu Tố Liên Quan Của Bệnh Viêm Da Cơ Địa Mức Độ Nặng Tại Bệnh Viện Da Liễu Trung Ương

“…15 Kết quả này cũng phù hợp với nghiên cứu của nhiều tác giả trong nước. [16][17][18] 23 Trong nghiên cứu của chúng tôi, tỷ lệ bệnh nhân nam bị VDCĐ nặng chiếm 61,4%, khác biệt có ý nghĩa thống kê so với p = 0,03. Độ tuổi trung bình của bệnh nhân là 34,5 ± 25,4, trong đó bệnh nhân lớn tuổi nhất là 90 tuổi.…”

Prevalence of atopic dermatitis in the adolescent population of Catalonia (Spain)

“…Atopy and its allergic responses are associated with increased serum total immunoglobulin E (tIgE) production. 14 Therefore, tIgE was also provided in the AQUAS dataset and was used to calculate the median (confidence interval [CI]) and the number of individuals above and below the cut-off point value (≥100 KU/L were considered as high levels) for the total adolescent population by disease severity and by comorbidities. The maximum value reported for everyone between the 2016 and 2017 study was taken.…”